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放疗及其时机对组织扩张器-假体植入乳房重建的影响及研究进展
祁艺航, 孔祥溢, 王翔宇, 王靖
国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院乳腺外科 100021
Research progress in the effect of radiotherapy and its timing on tissue expander/prosthesis implantation-based breast reconstruction
Qi Yihang, Kong Xiangyi, Wang Xiangyu, Wang Jing
Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Abstract：As indications of radiotherapy in the treatment of breast cancer continue to expand, more and more patients need radiotherapy after mastectomy. With the development of breast reconstruction, radiotherapy and its timing will affect breast reconstruction while patients benefit from tumor treatment and may lead to different postoperative complications and cosmetic effects. How to optimize the comprehensive therapeutic strategies of postoperative breast reconstruction and radiotherapy for breast cancer, especially the techniques of breast reconstruction and the choices of radiotherapy timing, has become an issue of common concerns of multidisciplinary treatment involving radiotherapy, breast surgery, and plastic surgery. This paper aims to review and summarize the latest high-quality research in this field including the impact of radiotherapy and its timing on tissue expander/prosthetic breast reconstruction, rate of prosthetic reconstruction, and postoperative patient satisfaction so that scholars can understand the latest research progress of radiotherapy and breast reconstruction and clinicians can optimize therapeutic regimens.
Qi Yihang,Kong Xiangyi,Wang Xiangyu et al. Research progress in the effect of radiotherapy and its timing on tissue expander/prosthesis implantation-based breast reconstruction[J]. Chinese Journal of Radiation Oncology, 2020, 29(5): 392-395.
[1] 王晖,胡学庆,郭松雪,等. 中国女性乳腺癌患者乳房重建意愿的多中心调查[J]. 中华整形外科杂志, 2018, 34(2):110-115. DOI:10.3760/cma.j.issn.1009-4598.2018.02.007.
Wang H, Hu XQ, Guo SX, et al. A multicenter survey of breast reconstruction willingness of Chinese women with breast cancer[J]. Chin J Plast Surg, 2018, 34(2):110-115. DOI:10.3760/cma.j.issn.1009-4598.2018.02.007.
[2] Wilkins EG, Cederna PS, Lowery JC, et al. Prospective analysis of psychosocial outcomes in breast reconstruction:one-year postoperative results from the Michigan breast reconstruction outcome study[J]. Plast Reconst Surg, 2000, 106(5):1014-1025. DOI:10.1097/00006534-200010000-00010.
[3] Nano MT, Gill PG, Kollias J, et al. Psychological impact and cosmetic outcome of surgical breast cancer strategies[J]. Anz J Surg, 2010, 75(11):940-947. DOI:10.1111/j.1445-2197.2005.03517.x.
[4] Chao LF, Patel KM, Chen SC, et al. Monitoring patient-centered outcomes through the progression of breast reconstruction:a multicentered prospective longitudinal evaluation[J]. Breast Cancer Res Treat, 2014, 146(2):299-308. DOI:10.1007/s10549-014-3022-7.
[5] Arrick BA, Nathan CF. Glutathione metabolism as a determinant of therapeutic efficacy:a review[J]. Cancer Res, 1984, 44(10):4224-4232.
[6] Rani V, Deep G, Singh RK, et al. Oxidative stress and metabolic disorders:pathogenesis and therapeutic strategies[J]. Life Sci, 2016, 148:183-193. DOI:10.1016/j.lfs.2016.02.002.
[7] Inci I, Zhai W, Arni S, et al. N-acetylcysteine attenuates lung ischemia-reperfusion injury after lung transplantation[J]. Ann Thorac Surg, 2007, 84(1):240-246. DOI:10.1016/j.athoracsur.2007.03.082.
[8] Anderson PR, Hanlon AL, Mcneeley SW, et al. Low complication rates are achievable after postmastectomy breast reconstruction and radiation therapy[J]. Women′s Oncol Rev, 2004, 59(4):1080-1087. DOI:10.1016/j.ijrobp.2003.12.036.
[9] Mccarthy CM, Cordeiro PG, Disa JJ, et al. The impact of breast reconstruction on the oncologic efficacy of radiation therapy[J]. Ann Plast Surg, 2008, 61(5):585. DOI:10.1097/sap.0b013e318188897e.
[10] Taylor ME, Haffty BG, Rabinovitch R, et al. ACR appropriateness criteria? On postmastectomy radiotherapy:expert panel on radiation oncology-breast[J]. Int J Radiat Oncol Biol Phys, 2009, 73(4):997-1002. DOI:10.1016/j.ijrobp.2008.10.080.
[11] Halyard MY, American College of Radiology, et al. ACR Appropriateness Criteria®local-regional recurrence (LR) and salvage surgery:breast cancer[J]. Oncology, 2012, 28(2):157-164. DOI:10.1097/COC.0b013e3182439084.
[12] Clarke M, Collins R, Darby S, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival:an overview of the randomised trials[J]. Chin J Breast Dis, 2007, 366(9503):2087-2106. DOI:10.1016/S0140-6736(05)67887-7.
[13] Carlson RW, McCormick B. Update:NCCN breast cancer clinical practice guidelines[J]. J Natl Compr Canc Netw, 2005, 3(Suppl 1):S7-S11.
[14] Kesson EM, Allardice GM, George WD, et al. Effects of multidisciplinary team working on breast cancer survival:retrospective, comparative, interventional cohort study of 13 722 women[J]. BMJ, 2012, 344(26 Part 1):e2718-e2718. DOI:10.1136/bmj.e2718.
[15] Haubner F, Ohmann E, Pohl F, et al. Wound healing after radiation therapy:review of the literature[J]. Radiat Oncol, 2012, 7(1):162. DOI:10.1186/1748-717X-7-162.
[16] Mehta VK, Goffinet D. Postmastectomy radiation therapy after TRAM flap breast reconstruction[J]. Breast J, 2004, 10(2):118-122. DOI:10.1111/j.1075-122X.2004.21286.x.
[17] Ryan-Julie L. Ionizing radiation:the good, the bad, and the ugly[J]. J Invest Dermatol, 2012, 132(3):985-993. DOI:10.1038/jid.2011.411.
[18] Salvo N, Barnes E, Van DJ, et al. Prophylaxis and management of acute radiation-induced skin reactions:a systematic review of the literature[J]. Curr Oncol, 2010, 17(4):94-112. DOI:10.3747/co.v17i4.493.
[19] El-Sabawi B, Carey JN, Hagopian TM, et al. Radiation and breast reconstruction:algorithmic approach and evidence-based outcomes[J]. J Surg Oncol, 2016, 113(8):906-912. DOI:10.1002/jso.24143.
[20] Kronowitz SJ, Robb GL. Breast reconstruction with postmastectomy radiation therapy:current issues[J]. Plast Reconstr Surg, 2004, 114(4):950-960. DOI:10.1097/01.prs.0000133200.99826.7f.
[21] Coles CE, Moody AM, Wilson CB, et al. Reduction of radiotherapy-induced late complications in early breast cancer:the role of intensity-modulated radiation therapy and partial breast irradiation:part Ⅱ-radiotherapy strategies to reduce radiation-induced late effects[J]. Clin Oncol, 2005, 17(2):98-110. DOI:10.1016/j.clon.2004.08.010.
[22] Bentzen SM, Thames HD, Overgaard M. Latent-time estimation for late cutaneous and subcutaneous radiation reactions in a single-follow-up clinical study[J]. Radiother Oncol, 1989, 15(3):267-274. DOI:10.1016/0167-8140(89)90095-9.
[23] Ho AL, Bovill ES, Macadam SA, et al. Postmastectomy radiation therapy after immediate two-stage tissue expander/implant breast reconstruction:a University of British Columbia Perspective[J]. Plast Reconstr Surg, 2014, 134(1):e1-e10. DOI:10.1097/PRS.0000000000000292.
[24] Tallet AV, Salem N, Moutardier V, et al. Radiotherapy and immediate two-stage breast reconstruction with a tissue expander and implant:complications and esthetic results[J]. Int J Radiat Oncol Biol Phys, 2003, 57(1):136-142. DOI:10.1016/s0360-3016(03)00526-1.
[25] Cordeiro PG, Pusic AL, Disa JJ, et al. Irradiation after immediate tissue expander/implant breast reconstruction:outcomes, complications, aesthetic results, and satisfaction among 156 patients[J]. Plast Reconstr Surg, 2004, 113(3):877-881. DOI:10.1097/01.prs.0000105689.84930.e5.
[26] Baschnagel AM, Shah C, Wilkinson JB, et al. Failure rate and cosmesis of immediate tissue expander/implant breast reconstruction after postmastectomy irradiation[J]. Clin Breast Cancer, 2012, 12(6):428-432. DOI:10.1016/j.clbc.2012.09.001.
[27] Benediktsson K, Perbeck L. Capsular contracture around saline-filled and textured subcutaneously-placed implants in irradiated and non-irradiated breast cancer patients:five years of monitoring of a prospective trial[J]. J Plast Reconst Aesthet Surg, 2006, 59(1):27-34. DOI:10.1016/j.bjps.2005.08.005.
[28] Ricci JA, Epstein S, Momoh AO, et al. A meta-analysis of implant-based breast reconstruction and timing of adjuvant radiation therapy[J]. J Surg Res, 2017, 218:108-116. DOI:10.1016/j.jss.2017.05.072.
[29] Baschnagel AM, Shah C, Wilkinson JB, et al. Failure rate and cosmesis of immediate tissue expander/implant breast reconstruction after postmastectomy irradiation[J]. Clin Breast Cancer, 2012, 12:428-432. DOI:10.1016/j.clbc.2012.09.001.
[30] Agarwal S, Kidwell KM, Farberg A, et al. Immediate reconstruction of the radiated breast:recent trends contrary to traditional standards[J]. Ann Surg Oncol, 2015, 22(8):2551-2559. DOI:10.1245/s10434-014-4326-x.
[31] Momoh AO, Ahmed R, Kelley BP, et al. A systematic review of complications of implant-based breast reconstruction with pre-reconstruction and post-reconstruction radiation therapy[J]. Ann Surg Oncol, 2014, 21(1):118-124. DOI:10.1245/s10434-013-3284-z.
[32] Albornoz CR, Matros E, Mccarthy CM, et al. Implant breast reconstruction and radiation:a multicenter analysis of long-term health-related quality of life and satisfaction[J]. Ann Surg Oncol, 2014, 21(7):2159-2164. DOI:10.1245/s10434-014-3483-2.
[33] Chu FCH, Kaufmann TP, Dawson GA, et al. Radiation therapy of cancer in prosthetically augmented or reconstructed breasts[J]. Radiology, 1992, 185(2):429-433. DOI:10.1148/radiology.185.2.1410349.
2020, Vol. 29 
