Chinese Journal of Radiation Oncology

中华放射肿瘤学杂志

中华放射肿瘤学杂志

Office

Journal

Archive

RSS

Download

Instruction

Template

Quick Search

Advanced Search

Chinese Journal of Radiation Oncology

	2023 Vol.32 Issue.4 Published 2023-04-15

	Abdominal Tumors Thoracic Tumors Review Articles Physics·Technique·Biology Head and Neck Tumor

Head and Neck Tumor

	287	Long-term prognostic analysis of different treatment strategies for T₃-T₄ nasal sinus adenocarcinoma
		Lu Xiaoxu, Sun Xueming, Huang Rong, Wu Hui
		Objective To investigate the prognosis and influencing factors of different treatment strategies in T₃-T₄ nasal sinus adenocarcinoma. Methods The data of 93 cases of T₃-T₄ stage nasal sinus adenocarcinoma diagnosed from 2006 to 2018 were retrospectively analyzed. All patients were divided into combined operation group and non-operation group. The survival status and failure mode after corresponding treatment were analyzed. The enumeration data were analyzed by Chi-square test or Fisher's exact test. Survival analysis was performed by Kaplan-Meier method. Univariate analysis was conducted by log-rank test. Multivariate prognostic analysis was performed by Cox model. Results The average follow-up time in the whole cohort was 81.3 months (18-156 months). By the end of follow-up, a total of 38.7% (36/93) of patients had local recurrence, 14.0% (13/93) had distant metastasis, 17.2% (16/93) had local recurrence complicated with distant metastasis, and 28.0% (26/93) were stable. The overall 2-, 5-, and 10-year overall survival (OS) and progression free survival (PFS) rates were 83.5%, 59.3%, 31.8% and 73.6%, 40.7% and 25.3%, respectively. In univariate analysis, the PFS and OS of patients aged 46-64 years old (all P<0.001), male (P=0.022, P=0.001), patients with lesions located in the maxillary sinus (P=0.001, P<0.001), adenoid cystic carcinoma (P=0.001, P<0.001), non-invasion of orbital / clivus (P=0.041, P<0.001), GTV_Pdose>64 Gy (P=0.003, P=0.006) and N₁ stage (P=0.014, P=0.014) were statistically different among different treatment modes. Multivariate analysis showed that age ≥65 years old (P=0.012, P=0.005), orbital / clival invasion (P<0.001, P=0.005), and GTV_p dose ≤64 Gy (P<0.001, P=0.011) were the independent adverse prognostic factors affecting PFS and OS in T₃-T₄ stage nasal sinus adenocarcinoma. Conclusions The local failure rate of T₃-T₄ stage nasal sinus adenocarcinoma is high after treatment. Age, orbital / clival invasion, and GTV_p dosage are the independent adverse prognostic factors. Surgery based intervention is superior to other treatment strategies.
		2023 Vol. 32 (4): 287-292 [Abstract] ( 71 ) [HTML 1KB] [ PDF 0KB] ( 0 )

Thoracic Tumors

	293	The efficacy of postoperative radiotherapy in stage Ⅲ(N₂) non-small cell lung cancer: a meta analysis
		Ling Lixian, Zhou Shishi, Zheng Hongjuan, Yin Ruihua, Tang Mengjun, Fu Jianfei
		Objective To conduct meta analysis to compare the effect of complete resection with or without postoperative radiotherapy (PORT) on survival in stage Ⅲ(N₂) non-small cell lung cancer (NSCLC). Methods Relevant studies of the efficacy of PORT for stage Ⅲ(N₂) NSCLC were searched from Wanfang Data, PubMed, and Cochrane Library from January 2006 to January 2022. Literature screening, extraction of information and assessment of the risk of bias of the included literature was carried out by two independent researchers. Meta analysis was performed using R4.0.3 software. Results A total of 12 publications consisting of 2992 patients were included, 1479 cases in the PORT group and 1513 cases in the control group. PORT improved the overall survival (OS) and disease free survival (DFS) compared to the control group. Fixed-effects model meta analysis of 6 randomized controlled trials showed that PORT did not significantly reduce the risk of death (HR=0.98, 95%CI: 0.80-1.20). Fixed-effects model meta analysis of 6 retrospective studies showed that PORT improved prognosis (HR=0.68, 95%CI: 0.59-0.79). PORT could improve OS of patients with multiple (station) metastasis of ipsilateral mediastinum and / or submandibular lymph nodes (HR=0.89, 95%CI: 0.80-0.99). Conclusions PORT could improve OS and DFS in stage Ⅲ(N₂) NSCLC. A trend towards benefit can be observed in the subgroup with multiple/multi-station N2 metastasis.
		2023 Vol. 32 (4): 293-300 [Abstract] ( 71 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	301	Failure mode and long-term survival after neoadjuvant therapy for locally advanced esophageal squamous cell carcinoma
		Wang Ruiqi, Wang Lin, Hu Xiao, Ma Honglian, Qiu Guoqin, Wang Zhun, Sun Xiaojiang, Ji Yongling, Lai Xiaojing, Feng Wei, Sheng Liming, Wang Yuezhen, Zhou Xia, Jiang Youhua, Wang Changchun, Zhao Qiang, Yang Xun, Liu Jinshi, Zeng Jian, Jiang Haitao, Li Pu, Du Xianghui, Chen Qixun, Xu Yujin
		Objective To analyze the fail mode of neoadjuvant therapy combined with surgery for locally advanced esophageal squamous cell carcinoma (ESCC) after long-term follow-up. Methods Clinical data of consecutive 238 patients with locally advanced resectable ESCC who underwent neoadjuvant therapy combined with surgery in Zhejiang Cancer Hospital from September 2012 to October 2019 were retrospectively analyzed. The failure mode in the whole cohort was analyzed after long-term follow-up. The overall survival (OS) and disease free survival (DFS) rates were analyzed by Kaplan-Meier method. Survival differences were determined by log-rank test. Results The pathological complete response (pCR) rate was 42.0% in 238 patients. After a median follow-up of 46.1 months, tumor progression occurred in 96 patients (40.3%), including 25 patients (10.5%) with local recurrence, 61 patients (25.6%) with distant metastases, and 10 patients (4.2%) with simultaneous local recurrence and distant metastases. The median OS and DFS were 64.7 months and 49.9 months. And the 3-, 5-, and 7-year OS and DFS rates were 70.0%, 52.8%, 36.4% and 63.5%, 42.5%, and 30.0%, respectively. The 3-, 5-, and 7-year locoregional recurrence-free survival rates and distant metastasis-free survival rates were 86.0%, 71.4%, 61.2% and 70.6%, 55.9%, 43.0%. Compared with non-pCR patients, the overall progression rate and distant metastasis rate of pCR patients were lower (26.0% vs. 50.7%, 16.0% vs. 32.6%, both P<0.05). And the 3-, 5-, and 7-year OS (83.0% vs. 60.2%, 69.7% vs. 41.7%, 50.4% vs. 27.7%, all P<0.001) and DFS rates (80.4% vs. 51.4%, 63.9% vs. 31.2%, 45.9% vs. 20.3%, all P<0.001) were significantly better in pCR patients. Conclusions Distant metastasis is the main failure mode of patients with locally advanced ESCC after neoadjuvant therapy. Patients with postoperative pCR can achieve better long-term survival.
		2023 Vol. 32 (4): 301-306 [Abstract] ( 67 ) [HTML 1KB] [ PDF 0KB] ( 0 )

Abdominal Tumors

	307	Treatment and prognosis analysis of 205 patients with intracranial primary diffuse large B cell lymphoma
		Xiang Miao, Wang Hanyu, Zhu Dan, Chen Ye, Wang Jijin, Shao Han, Xia Yunfei, Zhang Yujing
		Objective To analyze the clinical efficacy and prognostic factors of intracranial primary diffuse large B-cell lymphoma (DLBCL). Methods Clinical data of 205 patients pathologically diagnosed with intracranial primary DLBCL at Sun Yat-sen University Cancer center from March 2001 to September 2020 were retrospectively analyzed. Among them, 101 patients were male and 104 female, the median age was 54 years old. Non-germinal center B cell (GCB) subtype accounted for 74.1%(126/170). A total of 177 patients received high-dose methotrexate (HD-MTX) and 91 patients received rituximab. After induction chemotherapy, 59 patients (30.4%) achieved complete response (CR), 112 patients (57.7%) achieved partial response (PR) or stable disease (SD). A total of 83 patients received consolidation or salvage radiotherapy, and only 14 patients received autologous stem cell transplantation (ASCT). The influence of pathological type, chemotherapy, rituximab treatment, radiotherapy and radiotherapy mode, ASCT and other factors on the overall survival (OS) and progression free survival (PFS) was evaluated. The survival rate was calculated by Kaplan-Meier method. Univariate prognostic analysis was performed by log-rank test. Multivariate prognostic analysis was conducted by COX model. Results The median follow-up time was 34 months. The 5-year OS and PFS rates were 55.6% and 44.2%, respectively. GCB subtype, chemotherapy with HD-MTX, rituximab treatment, remission status after induction chemotherapy, and radiotherapy were favorable prognostic factors for OS or PFS, in which the last three were the independent prognostic factors. Consolidation radiotherapy in patients who obtained CR after induction chemotherapy did not significantly improve survival, while salvage radiotherapy in patients who achieved PR/SD after induction chemotherapy significantly improved both OS and PFS(both P<0.01). Consolidation radiotherapy showed no significant survival difference compared with consolidation ASCT. Conclusions The non-GCB subtype of intracranial primary DLBCL is related to poor prognosis. The addition of rituximab to HD-MTX based induction chemotherapy can improve survival. Radiotherapy is still an important treatment for intracranial primary DLBCL, and there are limitations of ASCT in practical clinical application.
		2023 Vol. 32 (4): 307-312 [Abstract] ( 61 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	313	Diagnostic and prognostic value of bone marrow biopsy in patients with extranodal NK/T-cell lymphoma based on PET-CT staging
		Zheng Hao, Yang Yong, Qiu Yanyan, Liao Siqin, Huang Cheng, Shi Guiqing, Zhao Ruizhi, Tang Tianlan, Wang Shunyuan, Chen Silin, Liu Tingbo, Xu Benhua
		Objective To analyze the diagnostic and prognostic value of routine bone marrow examination in patients with extranodal NK/T-cell lymphoma (ENKTCL) based on PET-CT staging. Methods Clinical data of 186 patients who received bone marrow biopsy and bone marrow aspiration in Fujian Medical University Union Hospital from 2013 to 2021 were retrospectively analyzed. All patients were divided into bone marrow biopsy + bone marrow aspiration group (n=186) and PET-CT + bone marrow biopsy group (n=139). The sensitivity, specificity, positive and negative predictive values were compared between two groups. The data were analyzed and plotted. Survival analysis was performed using Kaplan-Meier method and log-rank test. Results In the whole cohort, 45 patients were positive for bone marrow biopsy, and 30 of them were positive for bone marrow aspiration. A total of 141 patients who were negative for bone marrow biopsy also achieved negative results for bone marrow aspiration. A total of 139 patients completed PET-CT staging and bone marrow biopsy. And 30 patients were diagnosed with positive bone marrow by PET-CT, in which 22 of them were confirmed positive by bone marrow biopsy. Among 109 patients diagnosed with negative bone marrow by PET-CT, 5 of them were confirmed positive by bone marrow biopsy. All these cases were classified as stage Ⅳ due to distant metastases. PET-CT had a diagnostic sensitivity of 81.5%, a specificity of 92.9%, a positive predictive value of 73.3%, and a negative predictive value of 95.4%. Among early stage (Ⅰ-Ⅱ stage) patients diagnosed with PET-CT, all of them were negative for bone marrow biopsy (the negative predictive value was 100%). In stage Ⅳ patients (n=55), the 1-year overall survival of patients with bone marrow involvement by bone marrow biopsy or PET-CT (n=35) compared with their counterparts with the involvement of other organs (n=20) was 28.7% vs.42.0% (P=0.13), and 1-year progression free survival rates was 23.2% vs. 23.3% in (P=0.94). Conclusions Routine bone marrow biopsy does not change the original staging of patients with early stage ENKTCL based on PET-CT staging. Advanced stage patients with positive bone marrow biopsy tend to obtain worse prognosis, indicating that bone marrow biopsy still has certain value.
		2023 Vol. 32 (4): 313-318 [Abstract] ( 66 ) [HTML 1KB] [ PDF 0KB] ( 0 )

Physics·Technique·Biology

	319	Automatic segmentation of organs at risk in head and neck carcinoma from radiation therapy using multi-scale fusion and attention based mechanisms
		Lin Xiaowei, Yang Ruijie, Li Ni, Qi Qi
		Objective To develop a multi-scale fusion and attention mechanism based image automatic segmentation method of organs at risk (OAR) from head and neck carcinoma radiotherapy. Methods We proposed a new OAR segmentation method for medical images of heads and necks based on the U-Net convolution neural network. Spatial and channel squeeze excitation (csSE) attention block were combined with the U-Net, aiming to enhance the feature expression ability. We also proposed a multi-scale block in the U-Net encoding stage to supplement characteristic information. Dice similarity coefficient (DSC) and 95% Hausdorff distance (HD) were used as evaluation criteria for deep learning performance. Results The segmentation of 22 OAR in the head and neck was performed according to the medical image computing computer assisted intervention (MICCAI) StructSeg2019 dataset. The proposed method improved the average segmentation accuracy by 3%-6% compared with existing methods. The average DSC in the segmentation of 22 OAR in the head and neck was 78.90% and the average 95%HD was 6.23 mm. Conclusion Automatic segmentation of OAR from the head and neck CT using multi-scale fusion and attention mechanism achieves high segmentation accuracy, which is promising for enhancing the accuracy and efficiency of radiotherapy in clinical practice.
		2023 Vol. 32 (4): 319-324 [Abstract] ( 83 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	325	A study on the conversion of prescribed dose for radiotherapy of logistic nanodosimetry model and microdosimetric kinetic model based on gamma analysis
		Yang Jingfen, Zhang Hui, Liu Xinguo, Dai Zhongying, He Pengbo, Ma Yuanyuan, Shen Guosheng, Chen Weiqiang, Li Qiang
		Objective To validate the feasibility of the gamma analysis method in the study of prescription dose conversion between logistic nanodosimetry model (LNDM) and microdosimetric kinetic model (MKM) basing on the Chinese self-developed model LNDM by applying clinical experiences of National Institute of Radiological Science (NIRS). Methods Physical dose distributions derived from the MKM- and LNDM-based carbon ion treatment plans were compared via the method of gamma analysis under the open-source treatment planning platform matRad. In this way, the prescribed dose conversion factor between the MKM- and LNDM-based treatment plans was obtained. Using water phantoms, the influence of geometric shape, size, depth of target volume (TV), prescribed dose and field setting on the conversion factor was investigated comprehensively. Moreover, preliminary verification of the acquired conversion factor was conducted on the C-shape model and a case of liver cancer patient. Results The conversion factor depended on the field setting rather than the TV shape. Under the condition of single field, the conversion factor was positively correlated with the size and depth of TV, and the prescribed dose. Moreover, the conversion factor was successfully verified using the C-shape model and the patient with liver cancer, where the gamma passing rates (2%/2 mm) of the physical dose distribution generated by the MKM and LNDM treatment plans were 92.79% and 91.19%, respectively. Conclusions The conversion factors (f=D_LNDM/D_MKM) obtained in this study might provide guidance for the prescribed dose setting during the carbon ion treatment planning based on the LNDM. Besides, the gamma analysis method could be used for the study of the prescribed dose conversion between different models.
		2023 Vol. 32 (4): 325-332 [Abstract] ( 75 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	333	A study on the suitability of HD-V2 film in ultra-high dose-rate electron beam dosimetry
		Mao Ronghu, Ma Leijie, Lei Hongchang, Chen Peng, Li Bing, Luo Hui, Liu Han, Cheng Xiuyan, Guo Wei, Ge Hong
		Objective To evaluate the usability of Gafchromic HD-V2 film for dose dosimetry in the ultra-high dose-rate (UD) electron beam from a modified medical linac, and to investigate the response between the energy and dose-rate dependence to the film. Methods The HD-V2 film was utilized to measure the average dose-rate of the UD electron beam. The measured result was compared with those by advanced Markus chamber and alanine pellets. And characteristics of the UD electron beam were also measured by HD-V2 film. Energy dependence of HD-V2 film at three beam energies (6 MV X-ray, 9 MeV and 16 MeV electron beam) was investigated by obtaining and comparing the calibration curves based on the clinical linear accelerator in the dose range of 10-300 Gy. The dose-rate dependence of HD-V2 film was also studied by varying the dose rate among 0.03 Gy/s, 0.06 Gy/s and 0.1 Gy/s, and range of 100-200 Gy/s. Results The measured average maximum dose-rate of 9 MeV UD electron beam at source skin distance (SSD) 100 cm was approximately 121 Gy/s using HD-V2 film, consistent with the results by advanced Markus chamber and alanine pellets. The measured percentage depth dose (PDD) curve parameters of the UD electron beam were similar to the conventional 9 MeV beam. The off-axis dose distribution of the UD electron beam showed the highest central axis, and the dose was gradually decreased with the increase of off-axis distance. The energy dependence of HD-V2 film had no dependency of 6 MV and 9, 16 MeV while measuring the dose in the range from 20 to 300 Gy. The HD-V2 film had no significant dose-rate dependency at the dose rate of 0.03 Gy/s, 0.06 Gy/s and 0.1 Gy/s for the clinical linear accelerator. Likewise, there was also no dose-rate dependence in the range 100-200 Gy/s in the modified machine. Conclusion HD-V2 film is suitable for measuring ultra-high dose rate electron beam, independent of energy and dose rate.
		2023 Vol. 32 (4): 333-338 [Abstract] ( 52 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	339	A markerless beam's eye view tumor tracking algorithm based on structure conversion and demons registration in medical image
		Guan Qi, Qiu Minmin, Huang Taiming, Zhong Jiajian, Luo Ning, Deng Yongjin
		Objective To propose a markerless beam's eye view (BEV) tumor tracking algorithm, which can be applied to megavolt (MV) images with poor image quality, multi-leaf collimator (MLC) occlusion and non-rigid deformation. Methods Window template matching, image structure transformation and demons non-rigid registration method were used to solve the registration problem in MV images. The quality assurance (QA) plan was generated in the phantom and executed after manually setting the treatment offset on the accelerator, and 682 electronic portal imaging device (EPID) images in the treatment process were collected as fixed images. Meanwhile, the digitally reconstructured radiograph (DRR) images corresponding to the field angle in the planning system were collected as floating images to verify the accuracy of the algorithm. In addition, a total of 533 images were collected from 21 cases of lung tumor treatment data for tumor tracking study, providing quantitative results of tumor location changes during treatment. Image similarity was used for third-party verification of tracking results. Results The algorithm could cope with different degrees (10%-80%) of image missing. In the phantom verification, 86.8% of the tracking errors were less than 3 mm, and 80% were less than 2 mm. Normalized mutual information (NMI) varied from 1.182±0.026 to 1.202±0.027 (P<0.005) before and after registration and the change of Hausdorff distance (HD) was from 57.767±6.474 to 56.664±6.733 (P<0.005). The case results were predominantly translational (-6.0 mm to 6.2 mm), but non-rigid deformation still existed. NMI varied from 1.216±0.031 to 1.225±0.031 (P<0.005) before and after registration and the change of HD was from 46.384±7.698 to 45.691±8.089 (P<0.005). Conclusions The proposed algorithm can cope with different degrees of image missing and performs well in non-rigid registration with data missing images which can be applied in different radiotherapy technologies. It provides a reference idea for processing MV images with multi-modality, partial data and poor image quality.
		2023 Vol. 32 (4): 339-346 [Abstract] ( 55 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	347	A preliminary study of apoptosis in tongue squamous cell carcinoma cells induced by hyperthermia via downregulation of Notch1/Jagged1/Hes1
		Lyu Yurong, Zheng He, Qi Jing, Lyu Siyi, Wang Jing
		Objective To observe the optimal time interval of multiple short-term hyperthermia in tongue squamous carcinoma Cal-27 cells, and investigate the role of Notch signaling pathway in hyperthermia-induced apoptosis of Cal-27 cells. Methods Cal-27 cells were placed into a 42℃ incubator for 45 min, and the second hyperthermia was performed at 6 h,12 h, 24 h, 48 h and 72 h later, respectively. Cell proliferation capacity was detected by CCK-8 assay at 0 h, 12 h and 24 h after the end of hyperthermia. After determining the optimal time interval of hyperthermia, multiple cycles of hyperthermia were performed, and the effects of hyperthermia on the proliferation and apoptosis of Cal-27 cells were detected by CCK-8 assay and flow cytometry, respectively. The changes in the expression of Notch1, Jagged1 and hairy and enhancer of split homolog-1 (Hes1) mRNA and proteins were analyzed by real-time reverse transcription PCR (qRT-PCR) and Western blot. All data were expressed as mean±SD. Two-group comparison was performed by one-way ANOVA. Results Hyperthermia at 42℃ for 45 min every 12 h consistently inhibited the proliferation of Cal-27 cells (P<0.05). Compared with the control group, hyperthermia in the experiment group significantly inhibited the proliferation and induced the apoptosis of Cal-27 cells after 7 cycles of hyperthermia (P<0.05), and the expression levels of Notch1, Jagged1 and Hes1 mRNA and proteins in the hyperthermia group were significantly down-regulated (all P<0.05). Conclusions The optimal time interval of hyperthermia to inhibit the proliferation of tongue squamous cells carcinoma Cal-27 cells is 12 h. Hyperthermia might induce the apoptosis of Cal-27 cells by inhibiting the Notch signaling pathway.
		2023 Vol. 32 (4): 347-352 [Abstract] ( 56 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	353	Expression of NF45 in laryngeal squamous cell carcinoma and its effect on radiation sensitivity of tumor cells
		Gulinaer Tuerdi, Zhu Chengbin, Zhao Hui, Dilinuer Nijiati
		Objective To investigate the expression of double-stranded RNA-binding protein nuclear factor 45 (NF45) in laryngeal squamous cell carcinoma (LSCC), and the effect of NF45 on the radiation sensitivity of LSCC cells and its mechanism. Methods NF45 expression in LSCC and adjacent tissues was detected by real-time reverse transcription PCR (qRT-PCR) and immunohistochemical staining. The NF45-ShRNA lentivirus was transfected into Hep-2 cells, and cell transfection efficiency was determined by qRT-PCR and Western blot . Hep-2 cells were randomly divided into the control group, 2 Gy group, sh-NC+2 Gy group and sh-NF45+2 Gy group. Lentivirus infection and 2Gy X-ray irradiation treatment were carried out. Cell proliferation activity was assessed by CCK-8 assay. Apoptosis rate was determined by flow cytometry. Hep-2 cells in each group were treated with mCherry-EGFP-LC3B. The levels of autophagy were detected by immunofluorescence staining. The ratio of autophagy-related protein microtubule-associated protein 1 light chain 3 (LC3)-Ⅱ/LC3-Ⅰ and the expression levels of Beclin-1 and p62 proteins were determined by Western blot. Results The expression level of NF45 in LSCC tissues was significantly higher than that in adjacent tissues (P<0.01). The relative expression levels of NF45 mRNA and protein in Hep-2 cells infected with NF45-shRNA were significantly lower than those in the control and sh-NC groups (all P<0.05). Compared with the control group, the cell proliferation activity was decreased, the apoptosis rate was increased, the intracellular autophagy-lysosome were increased, the ratio of LC3-Ⅱ/LC3-Ⅰ was increased, the relative expression levels of Beclin-1 protein were up-regulated, and the relative expression levels of p62 protein were down-regulated in the 2 Gy, sh-NC+2 Gy and sh-NF45+2 Gy groups (all P<0.05). Compared with the 2 Gy group, the cell proliferation activity was decreased, the apoptosis rate was increased, the intracellular autophagy lysosomes were increased, the LC3-Ⅱ/LC3-Ⅰ ratio was increased, the relative expression of Beclin-1 protein was up-regulated, and the relative expression of p62 protein was down-regulated in the sh-NF45+2 Gy group (all P<0.05). Conclusions The expression of NF45 is up-regulated in LSCC tissues. Targeted down-regulation of NF45 expression can inhibit the proliferation activity of LSCC cells, promote cell apoptosis, and improve the sensitivity of tumor cells to radiation. The mechanism may be related to the regulation of autophagy levels.
		2023 Vol. 32 (4): 353-359 [Abstract] ( 51 ) [HTML 1KB] [ PDF 0KB] ( 0 )

Review Articles

	360	The role of radiomics and artificial intelligence in predicting and evaluating the efficacy of neoadjuvant chemoradiotherapy for rectal cancer
		Ouyang Ganlu, Wang Xin
		Predicting and evaluating the efficacy of neoadjuvant therapy for rectal cancer are of clinical significance and health economic value. At present, exploring the methods of predicting and evaluating the efficacy of neoadjuvant therapy have become research hotspot, focus and difficulty at home and abroad. Radiomics and artificial intelligence (AI) are two rapidly developing technologies. It is worthy of integrating radiomics with AI to build a model for predicting and evaluating the efficacy of neoadjuvant therapy and support individualized clinical decision-making and treatment options. In this article, literature review related to neoadjuvant chemoradiotherapy for rectal cancer based on radiomics and AI was conducted, aiming to explore the prospect and advantages of radiomics and AI in the prediction and evaluation of neoadjuvant therapy.
		2023 Vol. 32 (4): 360-364 [Abstract] ( 56 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	365	Research progress on the application of radiomics in prognostic prediction of esophageal cancer
		Yu Nuo, Wang Xin
		Esophageal cancer is a tumor with high morbidity and mortality in China, which is generally diagnosed at late stage and yields poor prognosis. Early diagnosis and correct staging are the basis, and reasonable treatment is the most important. Radiomics can make use of existing imaging resources for deeper mining, and make secondary use of its potential high-throughput data through deep learning or machine learning, thereby establishing a radiomics prediction model. This may become an essential marker of tumor prognosis to predict overall survival or tumor progression, thus stratifying patients at different risk for individualized treatment. In this article, the basic concepts of radiomics, its application in prognostic prediction of esophageal cancer and its combination with clinical and genetic studies were reviewed.
		2023 Vol. 32 (4): 365-369 [Abstract] ( 73 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	370	Research progress on tumor treating fields combined with radiation therapy in the treatment of glioblastoma
		Qiao Qiao, Xiao Huiyu, Li Guang
		For patients with newly diagnosed glioblastoma, tumor treating fields (TTF) combined with temozolomide after radiation therapy is currently one of the standard therapeutic regimens. Recently, TTF has been increasingly applied in combination with radiation therapy since it can delay tumor DNA repair and increase DNA replication stress. The efficacy of TTF has been proven in clinical studies. However, no consensus has been reached regarding the theoretical basis, radiation dose, actual clinical operation, patients' benefit and safety, which remain controversial. In this article, research progress on these topics was reviewed.
		2023 Vol. 32 (4): 370-374 [Abstract] ( 67 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	375	Deterministic method of photon radiotherapy dose calculation
		Song Hongbing, Yang Xiong, Li Xiangpan
		Deterministic method is a numerical calculation method based on photon-electron coupled transport with high computational accuracy and speed, which has been widely applied in photon radiotherapy dose calculation in recent years. However, this method has been introduced into radiotherapy for only a short period of time, which has been rarely studied in China, and systematic understanding of its characteristics is still lacking. In this article, the principles of deterministic method, current development state and clinical application were reviewed, aiming to provide reference for carrying out relevant research.
		2023 Vol. 32 (4): 375-378 [Abstract] ( 56 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	379	Research progress on the oxygen depletion hypothesis of ultra-high dose rate radiotherapy
		Zhu Hongyu, Zhang Qixian, Deng Xiaowu
		In recent years, ultra-high dose rate (FLASH) radiotherapy has become one of the most advanced research topics in the field of radiotherapy. Experimental data indicate that FLASH radiotherapy can significantly reduce the irradiation damage in normal tissues while being as effective as clinical conventional dose rate radiotherapy in tumor control. The oxygen depletion hypothesis is considered as one of the key mechanisms underlying the FLASH effect. In this article, research progress on the discovery, experimental evidence and reaction principle of oxygen depletion was reviewed, the measurement methods and biological effect modeling methods of the oxygen depletion hypothesis were summarized, and the oxygen depletion difference between normal tissue and tumor was also discussed.
		2023 Vol. 32 (4): 379-383 [Abstract] ( 65 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	384	Advances in studies on the effect of epithelial-mesenchymal transformation on radiotherapy sensitivity of tumors
		Li Jiahui, Bai Yuju
		Radiotherapy is one of the most important methods in the treatment of malignant tumors. However, the decrease of radiosensitivity of tumor cells is the main reason affecting the efficacy of radiotherapy. Epithelial-mesenchymal transition (EMT) is a complex biological process that confers several characteristics necessary for the progression of malignant tumors, such as tumor initiation, aggressiveness, transmissibility, and tolerance to chemotherapy and radiotherapy. In addition, EMT can also be induced by radiation, which endows tumor cells with radiation resistance. Previous studies have shown that inhibition of EMT could enhance the radiosensitivity of tumor cells, but the overall understanding of the molecular mechanisms, key targets and pathways involved are still lacking. In this article, recent studies on the role of EMT in tumor radiation therapy were reviewed, focusing on the signaling pathway, EMT-induced transcription factors, aiming to deepen the understanding of the effect of EMT on the sensitivity of radiotherapy and provide ideas for improving the clinical therapeutic effect of radiotherapy.
		2023 Vol. 32 (4): 384-387 [Abstract] ( 59 ) [HTML 1KB] [ PDF 0KB] ( 0 )

中华放射肿瘤学杂志

News

More.....

Cooperation unit

友情链接

China Association for
　Science and Technology

Chinese Medical Association

Cancer Hospital of Chinese
　Academy of Medical
　Sciences Department of
　Radiation Oncology

Chinese Anti-Cancer
　Association

Chinese Journal of Lung
　Cancer

Cqvp

CNKI

Wanfang Data

More....