Chinese Journal of Radiation Oncology

中华放射肿瘤学杂志

中华放射肿瘤学杂志

Office

Journal

Archive

RSS

Download

Instruction

Template

Quick Search

Advanced Search

Chinese Journal of Radiation Oncology

	2019 Vol.28 Issue.5 Published 2019-05-15

	Head and Neck Tumors Abdominal Tumors Thoracic Tumors Investigation Research Symposium physic biology technique reviewarticles Physics.Biology.Technique

Investigation Research

	321	Quality control report of tumor radiotherapy in Zhejiang province
		Zhejiang Cancer Diagnosis and Treatment QalityControl Center, Chen Xiaozhong, Zhu Yuan, Di Xiaoyun, Yang Yongting, Ge Minghua, Chen Ming
		Objective To discover the existing problems and provide appropriate suggestions and countermeasures through the quality control inspection. MethodsA comprehensive quality control inspection was conducted for the radiotherapy equipment in 45 hospitals in Zhejiang province. The physical, technical, clinical and radiotherapy process and the parameters related to quality control were evaluated. Results As of December 31, 2017, a total of 62 linear accelerators from 45 hospitals have been assessed. In the radiotherapy process, multiple quality control problems were identified in terms of radiotherapy equipment configuration, clinical work quality, radiotherapy technology and personnel qualifications. Besides, unreasonable equipment configuration, shortage of radiotherapy staff, clinical work flow and the quality assurance of physical radiotherapy remained to be resolved. Conclusion Regular quality control of radiotherapy plays a pivotal role in ensuring the accuracy, effectiveness and medical safety of radiotherapy.
		2019 Vol. 28 (5): 321-325 [Abstract] ( 442 ) [HTML 1KB] [ PDF 0KB] ( 0 )

Head and Neck Tumors

	326	Meta-analysis of efficiency and safety of WBRT±temozolomide in treatment of brain metastases from NSCLC
		Luo Qing, Chen Fang, Chen Xumei, Leng Yuanxiu, Li Ning, Zou Yan, Hu Wei, Pan Yana
		Objective To compare the efficacy and safety between whole brain radiotherapy (WBRT) and WBRT combined with temozolomide (TMZ) in the treatment of non-small cell lung cancer with brain metastases. Methods According to the retrieval strategy,the Chinese and English literatures before February 2018 were retrieved from EMbase,Cochrane,PubMed,Wanfang database,Chongqing VIP and CNKI,The target literatures were selected according to the inclusion and exclusion criteria,The quality of the included studies and extracted data was independently assessed by 3 researchers,The RevMan 5,3 and STATA 12,0 software was used for statistical analysis,The Objective remission rate (ORR),the total survival period (OS),the progression-free survival (PFS),and the side effects of chemotherapy were evaluated. Results In total,17 trials consisting of 1128 patients were included,The Results of Meta-analysis demonstrated that compared with the WBRT group,the ORR was significantly higher (OR=2.54;95%CI:1.93-3.36;P<0.001),the PFS was significantly longer (MSR=1.329;95%CI:1.143-1.545;P<0,001),and the incidence of hematological toxicity (OR=3.44;95%CI:1.63-7.26;P<0.05) and the gastric intestinal reaction (OR=1.69;95%CI:1.24-2.31;P<0.05) was significantly higher in the WBRT+TMZ group,The heterogeneities were within the acceptable range with statistical significance,The Results of OS were invalid due to relatively large heterogeneity,The incidence of headache did not significantly differ between two groups (OR=1.05;95%CI:0.72-1.55;P=0,79). Conclusions Compared with WBRT alone,WBRT combined with TMZ is beneficial to improve the short-term efficacy,whereas the incidence of hematological toxicity and gastrointestinal reaction is higher,The occurrence of headache does not significantly differ between two groups,The benefit of long-term survival remains uncertain.
		2019 Vol. 28 (5): 326-333 [Abstract] ( 599 ) [HTML 1KB] [ PDF 0KB] ( 0 )

Thoracic Tumors

	334	Compared with radiotherapy concurrent chemoradiotherapy with nedaplatin-based versus cisplatin-based regimen in locally advanced non-small cell lung cancer
		Zhang Tao,Bi Nan,Zhou Zongmei,Chen Dongfu,Xiao Zefen,Feng Qinfu,Liang Jun,Lyu Jima,Wang Xin,Deng Lei,Wang Wenqing,Wang Luhua
		Objective To compare the clinical efficacy and toxicity between nedaplatin-and cisplatin-based regimens in patients with unresectable locally advanced non-small cell lung cancer (NSCLC) receiving concurrent chemoradiotherapy. Methods From January,2015 to December,2016, patients with unresectable locally advanced NSCLC receiving concurrent chemoradiotherapy were included in this study. Patients received thoracic radiotherapy (RT) combined with nedaplatin-based concurrent chemotherapy were enrolled in the nedaplatin group (n=38).Those treated with thoracic RT combined with cisplatin-based chemotherapy were allocated into the cisplatin group (n=84).The chemotherapy regime consisted of platinumin combination with paclitaxel or etoposide. Platinum combined with pemetrexed was adopted in patients with adenocarcinoma. Overall, the median age was 58 years old. Most of the patients were male (86.1%),77.0% of them had a history of smoking and 63.9% of the patients were pathologically diagnosed with squamous cell carcinoma. Besides,59.0% of the patients had ⅢB NSCLC. Results In the nedaplatin and cisplatin groups,the overall response rate (ORR) was 79% and 86%,and the disease control rate was 94% and 94%.The median follow-up time was 20 months. In the nedaplatin group, the 1-and 2-year PFS was 49% and 23%,and 67% and 39% in the cisplatin group (P=0.160).In the nedaplatin group, the 1-and 2-year OS was 91% and 72%,and 89% and 68% in the cisplatin group (P=0.552).Nine patients (24%) had ≥grade 3 adverse events in the nedaplatin group and 25 patients (30%) in the cisplatin group (P=0.488).No statistical significance was found in radiation-induced esophagitis, bone marrow suppression and gastrointestinal toxicity between two groups. One patient in the nedaplatin group presented with grade 3 radiation-induced pneumonitis and 2 patients died of radiation-induced pneumonitis in the cisplatin group. Conclusions Thoracic radiotherapy combined with nedaplatin-based chemotherapy is a promising option for patients with unresectable locally NSCLC. Compared with the cisplatin-based chemotherapy, nedaplatin-based regime yields equivalent clinical efficacy and less adverse events, especially suitable for the elderly patients with poor tolerance.
		2019 Vol. 28 (5): 334-338 [Abstract] ( 657 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	339	Association between the timing of brain metastases and the prognosis of small cell lung cancer
		Sun Han, Wang Youyou, Xu Kunpeng, Xu Liming, Qi Jing, Zhao Lujun
		Objective To investigate the association between the timing of brain metastases and the prognosis of patients with small cell lung cancer (SCLC). Methids A retrospective analysis was performed in 131 patients with limited-stage SCLC firstly metastasized to the brain were admitted to our hospital from 2007 to 2015.According to the median bone metastasis-free survival (BMFS),all patients were divided into A group (BMFS≤10 months,n=61) and B group (BMFS>10 months,n=70).The survival rates were analyzed using the Kaplan-Meier method. Between-group comparison was performed by log-rank test. The Cox regression model was used for multivariate prognostic analysis. Results In all 131 patients,the median overall survival (OS) and 1-,2-,and 3-year OS rates were 22.5 months,87.3%,44.7%,and 20.8%,respectively. The median OS after brain metastases and 1-and 2-year OS rates were 9.3 months,39.3% and 14.8%,respectively. No statistical significance was observed in the median OS after brain metastases between the A and B groups (8.6 vs. 9.3 months,P=0.695).Moreover,the OS after brain metastases did not significantly differ in patients without PCI or those receiving different therapies after brain metastases between two groups (P=0.240-0.731). Conclusions The timing of SCLC with brain metastases is significantly correlated with the OS rather than the OS after brain metastases. Therefore,prevention of brain metastases may be an effective approach to prolong the OS of patients with SCLC.
		2019 Vol. 28 (5): 339-343 [Abstract] ( 435 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	344	Two-dimensional speckle tracking imaging in assessing the left ventricular diastolic function of patients with esophageal carcinoma after radiotherapy
		Yang Fei, Chen Yong, Chen Yong, Yu Haidi, Liu Min
		Objective To evaluate the early injury and dynamic changes of the left ventricular diastolic function of patients with esophageal carcinoma after radiotherapy by using two-dimensional speckle tracking imaging (2D-STI). Methods From 2017 to 2018,echocardiography examinations were performed in 39 patients with esophageal carcinoma before, during and after the first thoracic radiotherapy to measure the left ventricular end diastolic volume (LVEDV),left ventricular end systolic volume (LVESV),left ventricular ejection fraction (LVEF),early diastolic mitral flow velocity/early diastolic mitral annular peak velocity (E/e′),left atrial volume (LAV),2D-STI parameters including the left ventricular global longitudinal strain (GLS),global systolic stain rate (GSRs),global early diastolic strain rate (GSRe),global late diastolic strain rate (GSRa) and E/GSRe ratio. According to the GLS of patients with esophageal carcinoma after radiotherapy (cumulative dose≥50 Gy),the patients were divided into good prognosis (n=23) and poor prognosis groups (n=16). The E/GSRe ratio was statistically compared between two groups. Results The E/e′and LAVI were increased significantly only after radiotherapy (both P<0.05),and LVEF was decreased significantly only after radiotherapy (P<0.05). The e′ tended to decline before, during and after radiotherapy (all P<0.05).GLS and GSRs were significantly decreased only after radiotherapy (both P<0.05), whereas GSRa was considerably decreased during radiotherapy (P<0.05).E/GSRe tended to increase (P<0.05). Compared with the good prognosis group, E/GSRe was significantly increased after radiotherapy in the poor prognosis group (P<0.05). Conclusions Diastolic dysfunction can occur in the early stage of radiation-induced heart injury. The global diastolic strain rate and E/GSRe obtained by 2D-STI can be used to assess the early left ventricular dysfunction. E/GSRe can be more sensitive to evaluate the clinical prognosis compared with the global diastolic strain rate.
		2019 Vol. 28 (5): 344-348 [Abstract] ( 318 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	349	Clinical efficacy and toxicity of intensity-modulated radiation therapy following prostatectomy for 98 elderly patients with prostate cancer
		Xu Yonggang, Zhong Qiuzi, Gao Hong, Zhao Ting, Xiu Xia, Li Gaofeng
		Objective To evaluate the clinical efficacy and toxicity of intensity-modulated radiation therapy (IMRT) following prostatectomy for elderly patients with prostate cancer. Methods Ninety-eight prostate cancer patients receiving IMRT after prostatectomy were included in this study. The median age was 68 years old. The number of patients with low-,middle-and high-risk prostate cancer was 10,21 and 67,respectively. Two patients had oligometastases (pelvic bone metastases).Sixty-four patients were treated with IMRT combined with endocrine therapy. Among them,43 cases received adjuvant volumetric modulated arc therapy (VMAT),and 55 patients received salvage IMRT.The median radiotherapy dose was 72 Gy for the tumor bed. Twenty-nine patients received radiotherapy of the pelvic node region with a median dose of 50 Gy. Results The median follow-up time was 40 months. The 5-year overall survival (OS),biochemical recurrence-free survival (BRFS) and local control (LC) were 90%,76% and 100%,respectively. The OS (88.8% vs. 90.8%,P=0.94),BRFS (75.9% vs. 71%,P=0.79) or LC (100% vs. 100%,P=0.32) did not significantly differ between the adjuvant and salvage radiotherapy groups,respectively. The incidence of grade I-Ⅱ late rectal toxicities was 24.1%,and no ≥ grade 3 late toxicity was observed. The incidence of grade 1-2 late bladder toxicities was 29.9%,and 3.4% for grade 3. Conclusion IMRT following prostatectomy yields high clinical efficacy and slight late toxicities in elderly patients with prostate cancer.
		2019 Vol. 28 (5): 349-352 [Abstract] ( 405 ) [HTML 1KB] [ PDF 0KB] ( 0 )

Abdominal Tumors

	353	Analysis of prognostic factors for recurrence of vaginal stump in 493 cases of stage Ⅰ-ⅡA cervical cancer after radical hysterectomy
		Liu Guangrong, Ran Li, Ji Wei, Yu Miao, Chang Jianying, Li Fenghu, Li Jiehui
		Objective To explore the prognostic factors for the recurrence of vaginal stump of early-stage cervical cancer after radical hysterectomy and evaluate the effect on clinical prognosis.Methods Clinical data of stage Ⅰ-ⅡA cervical cancer patients undergoing radical hysterectomy in Guizhou Cancer Hospital from January, 2007 to December, 2016 were retrospectively analyzed.Results A total of 493 patients were enrolled and followed up until May 30, 2018.Among them, 96.6%(474/493) completed the follow-up.The median age was 45 years. Patients aged 40-50 years had a high incidence rate.In total, 451 cases (91.48%) had no recurrence of vaginal stump. The average time without stump recurrence was 51.2 months and the median time without stump recurrence was 44.8 months. MultivariateCox regressionanalysis demonstrated that pelvic external irradiation and brachytherapy were the independent prognostic factors for the recurrence of vaginal stump (P=0.000,0.000).Tumor size, lymph node metastasis and pelvic external irradiation were the independent prognostic factors for overall survival (P=0.045,0.022,0.000).Conclusions Pelvic external irradiation and brachytherapy play an extremely pivotal role in reducing the risk of vaginal stump recurrence after radical hysterectomy for patients with stage Ⅰ-Ⅱ A cervical cancer. Tumor size, lymph node metastasis and pelvic external irradiation are the independent prognostic factors for overall survival of patients with stage Ⅰ-ⅡA cervical cancer following radical hysterectomy.
		2019 Vol. 28 (5): 353-357 [Abstract] ( 341 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	358	Effect of different therapeutic methods on survival of stage Ⅰ-ⅡA cervical cancer patients complicated with postoperative intermediate risk factors
		Ji Wei, Ran Li, Chang Jianying, Li Fenghu, Li Jiehui, Liu Guangrong, Yu Miao
		Objective To compare the effect of different therapeutic Methods upon the survival of stage Ⅰ-ⅡA cervical cancer patients with intermediate risk factors and explore the optimal treatment for patients with early-stage cervical cancer undergoing radical hysterectomy and pelvic lymphadenectomy.Methods Clinical data of 323 patients with the following intermediate risk factors of lymphovascular space invasion, depth of stromal invasion or tumor size>4 cm were retrospectively analyzed. The impact of observing (NT),chemotherapy (CT),radiotherapy (RT) and concurrent chemoradiotherapy (CCRT) on survival was statistically compared. The Kaplan-Meier method was used to survival analysis,and log-rank test difference,Cox model was used to prognostic factor analysis.Results The 5-year progression-free survival (PFS) and overall survival (OS) of all patients were 79.0% and 84.8%. Univariate and multivariate analyses demonstrated that TS> 4 cm and therapeutic method were the independent prognostic factors of PFS. The number of risk factors and therapeutic method were the independent prognostic factors of OS. In the whole group, both RT and CCRT could improve the prognosis of patients with no statistical significance (P>0.05). In the subgroup analysis, for patients with a single intermediate risk factor (low risk group), CT could significantly prolong the PFS (P=0.026) rather the 5-year OS (P=0.692). Compared with NT and CT, RT and CCRT could improve the PFS and OS, whereas no statistical significance was noted between the RT and CCRT (both P>0.05). For those with ≥2 risk factors (high risk group), CCRT could significantly prolong the PFS compared with CT (84.9% vs. 70%;P=0.006), but did not improve the OS (P=0.107). Compared with RT, CCRT could significantly improve the PFS and OS (both P<0.05).Conclusions For patients with only one risk factor, RT can enhance the clinical prognosis. CCRT can improve the clinical prognosis of stage Ⅰ-ⅡA cervical cancer patients with ≥2 risk factors.
		2019 Vol. 28 (5): 358-363 [Abstract] ( 428 ) [HTML 1KB] [ PDF 0KB] ( 0 )

Physics.Biology.Technique

	364	Influence of collimator angle optimization on intensity-modulated radiotherapy planning for gastric cancer
		Su Huanfan, Zhang Jun, Liu Hui, Quan Hong, Cao Tingting, Lv Meng, Liang Zhiwen
		Objective To investigate the impact of four different collimator angle optimization techniques on the planning target volume (PTV) and organ at risk (OAR) during intensity-modulated radiotherapy (IMRT) for gastric cancer.Methods Ten patients with gastric cancer undergoing IMRT in Zhongnan Hospital of Wuhan University from 2015 to 2016 years were recruited in this study. All IMRT plans were designed by conventional five fields (330°,10°,45°,90°and 180°).In the Eclipse treatment planning system,four different collimator angle optimization techniques with consistent planning optimization parameters were employed to design the IMRT plan. Collimator angle optimization techniques included the following aspects. The collimator angle was set at 0 degree (CL0),collimator angle was set at 90 degree (CL90),Eclipse automatic collimator angle optimization (CLA) was adopted and collimator angle was set as the angle when the distance between X-Jaws and PTV (CLX) was the shortest. The dosimetric parameters mainly included the conformal index (CI) of PTV,the homogeneity index (HI),the mean dose (Mean),and the dosage of OAR.The treatment time (Time),monitor unit (MU),control point (CP),split field (SF) and conformal distance (Fx) were also considered.Results Regarding CL0 as the control,the CI,HI and Mean did not significantly differ among four collimator angle optimization techniques (all P>0.05),whereas CLX could significantly increase the average dose of PTV in the target area (P<0.05);CLX optimization reduced the liver(V30 reduction by 1.54%),left kidney(V12 decrease by 1.46%),right kidney and other OARs,whereas it slightly increased the maximum dose of the small intestine and spinal cord (<1%).CL90 and CLA optimization elevated the dose of OAR in gastric cancer. Among four different collimator angle optimization techniques,CLX optimization reduced the MU (25.02%),CP (26.03%),Fx (20.27%) and SF (by 1.3 separate fields on average) and treatment time (10.03%).CL90 and CLA optimization could decrease the MU,CP,Fx and SF.CL90 optimization had certain advantages in shortening the treatment time,whereas CLA optimization could prolong the treatment time by 5.04%.Conclusions During IMRT for gastric cancer,CL90,CLA and CLX collimator angle optimization techniques can obtain comparable dosimetry distribution to CL0 optimization technique,which can reduce the MU,decrease the radiation leakage,shorten the treatment time and improve treatment efficiency.
		2019 Vol. 28 (5): 364-368 [Abstract] ( 375 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	369	Comparison of imbolization accuracy between styrofoam and breast carrier in intensity-modulated radiotherapy after breast conservative surgery for breast cancer patients
		Fang Jianhui, Ma Yujia, Shi Juntian, Huang Jianghua, Wu Xiuxiu, Ma Shuang, Cheng Jinshu, Huang Xiaobo
		Objective To investigate the difference of styrofoam and breast carrier in postposition fixation of intensity-modulated radiotherapy after breast conservative surgery for breast cancer patients.Methods From February 2018 to August 2018,tweenty-four patients with breast cancer in Sun Yet-Sen Memorial Hospital of Sun Yet-sen University were selected for this study, who underwent hypofactionationed radiotherapy after breast conservative surgery with total dose 42.56 Gy/16Fractions. They were randomized into styrofoam test group and breastcarrier control group. Cone beam CT as used to record the positioning error under the directions of left and right (x),head and foot (y),abdomen and back (y) within two groups at the first,third,fifth,seventh, eleventh time before irradiation. Furthermore,the PTV extension margin was calculated and the positioning time of two groups was recorded. Two sets of pendulum errors were analyzed by independent sample T-test,and the outspread value of inter-fractional set up error of the PTV was calculated.Results The errors of the test group and the control group in the direction of x,y,z were as follows:(2.36±1.89) and (2.56±2.05) mm (P=0.49),(1.76±1.78) and (3.28±2.79) mm (P<0.05),(1.47±1.49) and (1.73±1.81) mm (P=0.28).The extension values of inter-fractional set up error of CTV to PTV were 2.97,2.92,2.21 mm and 3.41,4.09,2.59 mm respectively. The time of single positioning was (3.4±1.1) and (5.5 ±3.1) min respectively (P=0.01).Conclusions Styrofoam has better positioning accuracy and efficiency compared with breast carrier.
		2019 Vol. 28 (5): 369-372 [Abstract] ( 443 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	373	A setting approach for tolerance table of couch position in record and verify system
		Huang Peng, Hu Zhihui, Fu Guishan, Zhang Yin, Qin Shirui, Dai Jianrong
		Objective To evaluate the effect of the tolerance table of different couch positions in the record and verify system (R&V system) upon the setup accuracy.Methods Clinical data of 715 patients (15743 fractions of treatment) were extracted from the R&V system database and assigned into four categories including thorax and abdomen,head and neck,breast,and rectum based on the disease site and immobilization device. The first day couch position (FstD) and cumulative average couch position (CumA) were utilized as the references to analyze the couch setup of each faction of treatment,and to establish the tolerance tables of different sites. The sensitivity and specificity of two Methods were evaluated by the actual clinical treatment record of the patients.Results For the FstD as the reference,the couch tolerance in the breast was significantly higher than those in other parts. When the CumA was used as the reference,the couch tolerance tended to be stable after a certain fractions of treatment,and the tolerance of all sites was less than that of the FstD.The tolerance tables significantly differed between these two Methods (P=0.000).Both two Methods possessed high specificity,whereas the CumA method yielded higher sensitivity than the FstD approach.Conclusions Setting a reasonable tolerance table of couch position can effectively improve the setup accuracy.
		2019 Vol. 28 (5): 373-377 [Abstract] ( 371 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	378	Mir-361-5p enhances radiosensitivity of osteosarcoma cells by directly downregulating FOXM1
		Ding Shuai, Gao Yanzheng, Zhang Guangquan, Chen Shulian, Cao Chen, Li Baiyu
		Objective To investigate the effect of microRNA361-5p on radiosensitivity of osteosarcoma cells and its downstream regulatory mechanisms.Methods The radioresistant osteosarcoma cell line HOS-R was constructed and the expression of microRNA-361-5p in HOS and HOS-R cells was detected by RT-qPCR.The survival rate and apoptosis rate were detected by clone formation assay and flow cytometry in HOS-R cells treated with up-regulated or down-regulated of miR-361-5p,or FOXM1 depletion. Dual fluorescent luciferase reporter and western blot assays were used to measure the relationship between miR-361-5p and FOXM1.he effects of miR-361-5p on radiosensitivity of osteosarcoma cells were determined by cloning formation assay and flow cytometry.Results RT-qPCRResults showed that miR-361-5p was low expressed in HOS-R cells. Colony formation and flow cytometry assays demonstrated that overexpression of miR-361-5p significantly decreased the survival rate and increased the apoptosis rate of HOS-R cells. In contrast,FOXM1 downregulation inhibited cell survival rate and induced apoptosis. Moreover,miR-361-5p negatively regulated FOXM1 expression. Besides,FOXM1 overexpression attenuated the miR-361-5p upregulation-mediated promotion of radiosensitivity in HOS-R cells.Conclusion miR-361-5p was involved in the radiosensitivity of osteosarcoma cells by inhibiting FOXM1.
		2019 Vol. 28 (5): 378-381 [Abstract] ( 394 ) [HTML 1KB] [ PDF 0KB] ( 0 )

physic biology technique

	382	Silencing ANO9 increases the radiosensitivity of pancreatic cancer cell AsPC-1
		Zhao Dongmei, Ma Yanying, Wang Wen, Li xu
		Objective To evaluate the effect of ANO9 on the radiosensitivity of pancreatic cancer cell AsPC-1, aiming to provide new targets for clinical radiotherapy of pancreatic cancer. Methods Western blot was performed to detect the expression of ANO9 in pancreatic cancer cell lines (BxPC-3, PANC-1, AsPC-1) and normal pancreatic cell line (HPNE). The AsPC-1 cell line with stable silencing ANO9 was constructed by using lentivirus and validated by Western blot. MTT assay was adopted to detect the cell viability of AsPC-1 with stable silencing ANO9 after irradiation. Colony formation assay was conducted to evaluate the effect of silencing ANO9 upon the radiosensitivity of AsPC-1 cells. Western blot was performed to assess the effect of ANO9 silencing on the expression of EGFR/ERK signaling protein. Results The expression levels of ANO9 were significantly up-regulated in three pancreatic cancer cell lines compared with that in the normal pancreatic cell line HPNE (t=7.426, 5.543, 11.850, all P<0.05). After silencing ANO⁹, the expression level of ANO9 protein was significantly down-regulated than that in the control group (t= 9.670, P<0. 05). The AsPC-1 cells with stable silencing ANO9 were successfully constructed. The sensitivity of AsPC-1 cells to irradiation was significantly increased after silencing ANO⁹, and the sensitivity enhancement ratio was 1.566. The expression levels of EGFR/ERK signaling proteins (EGFR and p-ERK1/2) were significantly down-regulated after silencing ANO9(t=7.949, 13.160, both P<0.05).Conclusions Silencing ANO9 can significantly increase the sensitivity of AsPC-1 cells to radiotherapy, which is probably associated with the inhibition of EGFR/ERK signaling transduction. ANO9 might be a new therapeutic target for preventing the progression of pancreatic cancer.
		2019 Vol. 28 (5): 382-384 [Abstract] ( 327 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	385	Interfering with glutathione S-transferase P1 induces lung cell damage under irradiation conditions
		He Qiduo, Ma Na, Du Lehui, Yang Zhihua, Wang Yilong, Sun Zewen, Yu Wei, Huang Xiang, Zhu Maoxiang, Qu Baolin
		Objective To investigate the association and mechanism between glutathione S-transferase P1(GSTP1) and radiation-induced lung injury. Methods Two effective GSTP1 siRNAs were designed and synthesized. The normal lung epithelial cell line BEAS-2B cells were transfected with GSTP1 siRNA (experimental group,siRNA-1,siRNA-2) and negative control siRNA (negative control group,NC).Western blot was performed to detect the expression levels of GSTP1 protein and EMT-related proteins. CDNB was adopted to evaluate the activity of GSTs. DCFH-DA probe was used for incubation. Flow cytometry was conducted to detect the median fluorescence intensity (MFI) and cellular apoptosis. Annexin-v/PI staining was utilized for incubation. MTT assay was performed to measure the proliferation of BEAS-2B,and the growth curve was drawn based on the results. Results After radiation,compared with the NC group,the ROS level and MFI were significantly higher in experimental group (6774.66±399.60 vs.8759.00±256.96 vs.9967.67±735.11,P<0.05).In the experimental group,the percentage of cellular apoptosis was remarkably higher than that in the NC group (12.3±1.16 vs.17.38±1.65 vs.22.88±1.20,P<0.05).MTT assay demonstrated that the OD values in the experimental group were significantly lower than that in the NC group everyday. Further more,the level of EMT process is higher in the experimental group. Conclusions Interfering with the GSTP1 expression in lung epithelial cells can increase the intracellular ROS level,increase the percentage of cellular apoptosis,and reduce the cell proliferation rate following γ-radiation. Besides,it can also promote the epithelial mesenchymal transition in lung epithelial cells. The down-regulation of GSTP1 protein expression level probably aggravates the radiation-induced lung cell injury and promotes the epithelial mesenchymal transition.
		2019 Vol. 28 (5): 385-388 [Abstract] ( 309 ) [HTML 1KB] [ PDF 0KB] ( 0 )

reviewarticles

	389	Research progress on stereotactic radiotherapy combined with immunotherapy for malignancies
		Zhu Xiaopeng, Liu Bailong, Li Cheng, Lv Jincai, Quan Xiaoyue, Liu Min, Dong Lihua
		Surgery, radiotherapy and chemotherapy are three traditional treatments for malignant tumors. With the development of medicine, immunotherapy has been gradually adopted as an emerging therapy of malignancies. Recent clinical studies have demonstrated that the combination of radiotherapy and immunotherapy can induce the abscopal effect and improve the prognosis of patients. Compared with the conventional radiotherapy, stereotactic radiotherapy has a larger single dose and higher accuracy, which is more likely to induce the bystander effect and anti-tumor response. The combination of stereotactic radiotherapy and immunotherapy has been proven to be a more promising therapy in certain clinical trials. However, not all types of tumors can benefit from such combined therapy in clinical practice. The optimal dose, fraction pattern and lesion of radiotherapy, immune enhancement and safety remain to be further clarified. In this article, the research progress, related controversies and future research direction of stereotactic radiotherapy combined with immunotherapy for malignancies were reviewed.
		2019 Vol. 28 (5): 389-393 [Abstract] ( 417 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	394	Research progress of statins in neoadjuvant radiotherapy and chemotherapy for rectal cancer
		Xie Shurui, Xu Benhua
		Neoadjuvant chemoradiotherapy followed by TME is a common treatment at present for locally advanced rectal cancer. Several studies abroad in recent years have shown that statins have a positive effect on cancer resistance. We discussed the mechanism and clinical application of statins in preoperative neoadjuvant chemoradiotherapy of locally advanced rectal cancer.
		2019 Vol. 28 (5): 394-397 [Abstract] ( 372 ) [HTML 1KB] [ PDF 0KB] ( 0 )

symposium

	398	BMAG interlock troubleshooting of Varian clinac IX linear accelerator
		Chen Xiao, Liu Xuhong
		Through the analysis of 3 maintenance of Bmag interlocking fault of Varian Clinac IX Linear Accelerator, it is found that the full wave rectifier diode breakdown in the bend magnet power supply, the improper setting of the bend magnet interlock, and the failure of the modulator CB3 air switch can cause the bmag interlocking. Through the replacement of accessories, adjustment parameters, etc., so that the fault is resolved.
		2019 Vol. 28 (5): 398-399 [Abstract] ( 635 ) [HTML 1KB] [ PDF 0KB] ( 0 )

中华放射肿瘤学杂志

News

More.....

Cooperation unit

友情链接

China Association for
　Science and Technology

Chinese Medical Association

Cancer Hospital of Chinese
　Academy of Medical
　Sciences Department of
　Radiation Oncology

Chinese Anti-Cancer
　Association

Chinese Journal of Lung
　Cancer

Cqvp

CNKI

Wanfang Data

More....