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Research advances in postoperative concurrent chemoradiotherapy (CCRT) for high-risk early stage cervical cancer
Nie Fangfang, Chen Xiaoqin, Fu Jie
Department of Radiation Oncology,Shanghai Jiaotong University Affliated Sixth People’s Hospital,Shanghai,200233,China (Nie FF,Fu J);Department of Gynecology,Fudan University Affliated Cancer Hospital,Shanghai 200232,China (Chen XQ)
Abstract Cervical cancer is one of the most common gynecologic malignancy,ranking fourth in new cases and deaths in 2012.High-risk early stage cervical cancer after operative need adjuvant treatment. Compared with postoperative radiotherapy alone,CCRT can reduce the pelvic recurrence rates and improve survival rates. And CCRT can extend median survival time and survival rates than sequential CRT after operative. CCRT plus consolidation chemotherapy may play a potential role in further improving survival outcomes for high-risk early stage cervical cancer patients compared with CCRT alone. Retrospective studies show that CCRT had equivalent effects with postoperative chemotherapy alone,but further research is needed. Factors influencing the efficacy of postoperative CCRT include chemotherapy regimens,radiotherapy technology,the interval time between surgery and CCRT,multiple pelvic lymph node metastasis and number of pelvic lymph node dissection. Toxicities mainly include hematologic and gastrointestinal toxicity. Hematologic toxicity is the most common. The incidence of toxicity can be reduced by improving radiotherapy techniques.
Fund:Shanghai Shenkang Hospital Development Center Funds for Three Year Action Plan for Promoting Clinical Skills and Clinical Innovation Capacity in Municipal Hospitals (16CR3112B)
Corresponding Authors:
Fu Jie,Email:fujie74@sjtu.edu.cn
Cite this article:
Nie Fangfang,Chen Xiaoqin,Fu Jie. Research advances in postoperative concurrent chemoradiotherapy (CCRT) for high-risk early stage cervical cancer[J]. Chinese Journal of Radiation Oncology, 2017, 26(12): 1470-1474.
Nie Fangfang,Chen Xiaoqin,Fu Jie. Research advances in postoperative concurrent chemoradiotherapy (CCRT) for high-risk early stage cervical cancer[J]. Chinese Journal of Radiation Oncology, 2017, 26(12): 1470-1474.
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