<sup>125</sup>I粒子植入术对荷神经母细胞瘤裸鼠有效性和安全性实验研究

doi:10.3760/cma.j.issn.1004-4221.2017.05.018

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Abstract

Objective To examine the efficacy and safety of ¹²⁵I seed implantation for treating neuroblastoma (NB) in animal models.Methods A total of 45 nude mice models of neuroblastoma were constructed and divided into the ¹²⁵I group.control group.and blank group at 15 mice per group. The long and short diameters of the tumor were measured every 3 days.and the tumor inhibition rate was calculated every 9 days. Apoptotic and proliferative protein expression levels in tumor tissue and peritumoral tissue.as well as endocrine markers and bone marrow of the nude mice.were analyzed. The independent sample t test was used to compare the mean scores.and ANOVA was used for comparison between multiple groups. Results Tumor volume inhibition rate was significantly higher in the ¹²⁵I group than in the control group and blank group on days 9.18.and 27(all P<0.05).Caspase-3 expression in tumor tissues was significantly higher in the ¹²⁵I group than in the control group and blank group (all P<0.05).whereas proliferating cell nuclear antigen (PCNA) expression was significantly lower in the ¹²⁵I group than in the control group and blank group (all P<0.05).There was no significant difference in Caspase-3 and PCNA expression between the control group and blank group (all P>0.05).In addition.no significant difference in the expression of Caspase-3 and PCNA in peritumoral tissue was observed between the ¹²⁵I group.control group.and blank group (all P>0.05).Cell apoptosis in tumor tissue was significantly lower in the blank group and control group than in the ¹²⁵I group (all P<0.05).while there was no significant difference between the blank group and the control group (P>0.05).There was no significant difference in endocrine markers between the three groups (P>0.05).There was no significant bone marrow suppression in the ¹²⁵I group.and this observation was similar to those in the control group and blank group (all P>0.05).Conclusions ¹²⁵I seeds have significant toxicity to NB.¹²⁵I seed implantation is safe in nude mice with NB within the therapeutic doses.

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	Articles by authors
	Zhang Wang
	Yang Yan
	Lyu Linya
	Wang Shan
	Kong Xiangru
	Zhang Jun
	Yang Jiao
	Wang Yuchan

Key words： seeds Neuroblastoma Nude mice Efficacy Safety

Received: 16 June 2016

Corresponding Authors: Lyu Linya. Email:1905469939@qq.com

Cite this article:

Zhang Wang,Yang Yan,Lyu Linya et al. Efficacy and safety of ¹²⁵I seed implantation for treating neuroblastoma in nude mice[J]. Chinese Journal of Radiation Oncology, 2017, 26(5): 565-571.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2017.05.018 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2017/V26/I5/565

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