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Preliminary observation of the safety of template-assisted 192Ir source hypofractionated stereotactic ablative brachytherapy for locally advanced non-small cell lung cancer
Shi Xiangxiang,Tang Tao,Pang Haowen,Sun Xiaoyang,Wu Jingbo,Lin Sheng
Department of Oncology,Affiliated Hospital of Southwest Medical University,Luzhou 646000,China
AbstractObjective To preliminarily evaluate the safety of the coplanar template-assisted 192Ir hypofractionated stereotactic ablative brachytherapy (SABT) in patients with locally advanced non-small cell lung cancer (LA-NSCLC),and assess the effect of template-assisted technology upon the accuracy of SABTby comparing the consistency of dosimetric parameters between preoperative and operative plans. Methods Fifteen patients histologically confirmed with LA-NSCLC (stage ⅡB-ⅢA) were recruited and received the template-assisted SABT delivered in a risk-adapted fractionation (30Gy/1F). Preoperative planning, template-assisted needle implantation, operative planning and implementation were performed in all patients. Dosimetric results of preoperative and operative plans were statistically compared by assessing the dosimetric parameters of gross tumor volume (HI,CI,D90,V100 and V150) and organ at risk(V5,V20 and mean dose of bilateral lung,D2cc of spinal cord. The incidence of perioperative complications of SABT was recorded. The safety and feasibility of SABT were evaluated. Results Slight changes were noted in terms of target dose and irradiated dose to the lung between preoperative and operative plans without statistical significance (both P>0.05). No severe adverse events, such as severe pneumothorax, hemothorax and hemoptysis were observed. Conclusions Application of the template-assisted SABT can enhance the accuracy of implantation, maintain the consistency of the dosimetric parameters between the preoperative and operative plans and guarantee the clinical efficacy.
Corresponding Authors:
Lin Sheng,Email:lslinsheng@163.com
Cite this article:
Shi Xiangxiang,Tang Tao,Pang Haowen et al. Preliminary observation of the safety of template-assisted 192Ir source hypofractionated stereotactic ablative brachytherapy for locally advanced non-small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2019, 28(9): 665-668.
Shi Xiangxiang,Tang Tao,Pang Haowen et al. Preliminary observation of the safety of template-assisted 192Ir source hypofractionated stereotactic ablative brachytherapy for locally advanced non-small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2019, 28(9): 665-668.
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