多模态MR图像测量鼻咽癌GTV一致性评价

doi:10.3760/cma.j.issn.1004-4221.2016.12.002

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Abstract Objective To investigate the consistency of multiple magnetic resonance imaging (MRI) modalities in measurement of gross tumor volume (GTV) for nasopharyngeal carcinoma. Methods A retrospective analysis was performed among 45 patients who were newly diagnosed and pathologically confirmed with nasopharyngeal carcinoma. All patients underwent plain, enhanced, and diffusion-weighted MRI scans. Primary tumor was manually delineated on enhanced axial T₁WI, axial T₂WI, and apparent diffusion coefficient (ADC) maps. GTV was calculated by the sum of areas. The obtained GTV was divided into T₁+C group, T₂WI group, and ADC group. One-way analysis of variance was used to evaluate the differences between the mean values from the three groups. The Bland-Altman method was used to evaluate the consistency of different imaging modalities in GTV measurement using the mean difference between the two groups and 95% distribution of the difference. Results There was no significant difference in mean GTV between the T₁+C group, the T₂WI group, and the ADC group (20.8±18.1) vs. (21.5±17.2) vs. (24.4±20.8) cm³(P=0.617). The mean differences and 95% limits of agreement between the T₂WI group and the T₁+C group, between the ADC group and the T₂WI group, and between the ADC group and the T₁+C group were 0.74, 2.94, and 3.68 cm³ and (-5.97-7.44),(-8.25-13.69), and (-3.34-10.70) cm³, respectively. Conclusions The multiple MRI modalities have poor consistency in measurement of GTV for nasopharyngeal carcinoma. Therefore, they cannot replace each other. Enhanced T₁WI combined with T₂WI and DWMRI can determine a relatively accurate range of target volume for nasopharyngeal carcinoma.

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	Articles by authors
	Gu Donglian
	Liu Shuying
	Zhu Xiaodong
	Lai Shaolyu
	Jin Guanqiao
	Su Danke

Key words： Multimodality magnetic resonance Gross tumor volumel Consistency

Received: 05 April 2016

Fund:National Natural Science Foundation of China (81260334, 81460452)

Corresponding Authors: Su Danke,Email:sudanke33@sina.com;Jin Guanqiao,Email:jgq8@sina.com

Cite this article:

Gu Donglian,Liu Shuying,Zhu Xiaodong et al. Assessment of consistency of multiple magnetic resonance imaging modalities in measurement of gross tumor volume for nasopharyngeal carcinoma[J]. Chinese Journal of Radiation Oncology, 2016, 25(12): 1281-1284.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2016.12.002 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2016/V25/I12/1281

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