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Relationship between factors of gross tumor volume and locoregional failure of radical intensity-modulated radiation therapy for esophageal carcinoma
Zeng Jing1,2, Pang Qingsong1, Zhang Wencheng1, Guan Yong1, Qian Dong1, Wang Ping1, Qu Pengpeng2, Zhao Lujun1, Wang Jun1, Wang Daquan1, Shi Xiangyu1, Liu Xiaojie1
1Department of Radiobiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Centre of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin′sClinical Medical Research Center for Cancer,Tianjin, Tianjin 300060, China; 2Department of Gynecology, Tianjin Central Hospital of Gynecology and Obstetrics, Tianjin 300100, China
AbstractObjective Investigate the relationship between gross tumor volume (GTV)-related factors includingGTV-T volume,the maximum thickness of the esophageal lesion plane and GTV-T volume/length(GTV-T volume divided by the length of the lesion calculated by the number of GTV-T layers) and the locoregional failure of radical intensity-modulated radiation therapy (IMRT) for esophageal carcinoma. Methods A total of 133 patients with esophageal cancer undergoing radical IMRT were enrolled. The factors related to GTV-T including GTV-T volume, the maximum thickness of the esophageal lesions, GTV-T volume/length were calculated. The relationship between GTV-T related factors and local recurrence of tumors was retrospectively analyzed. Results There was positively linear association between the locoregional failure rate of GTV-T and the volume of GTV-T. The volume of GTV-T tumor was 36 cm3, the maximum wall thickness was 2.5 cm, and the GTV-T volume/length was calculated as 5.3 cm2. These critical values could be utilized to predict the risk of locoregional failure of IMRT for esophageal carcinoma. Conclusions The GTV-T factors can be adopted to predict the local control and the risk of locoregional failure of radical IMRT for esophageal carcinoma to certain extent.
Corresponding Authors:
Pang Qingsong, Email:pangqingsong2013@163.com
Cite this article:
Zeng Jing,Pang Qingsong,Zhang Wencheng et al. Relationship between factors of gross tumor volume and locoregional failure of radical intensity-modulated radiation therapy for esophageal carcinoma[J]. Chinese Journal of Radiation Oncology, 2019, 28(2): 85-89.
Zeng Jing,Pang Qingsong,Zhang Wencheng et al. Relationship between factors of gross tumor volume and locoregional failure of radical intensity-modulated radiation therapy for esophageal carcinoma[J]. Chinese Journal of Radiation Oncology, 2019, 28(2): 85-89.
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