食管癌术后辅助放化疗不良反应临床分析

doi:10.3760/cma.j.issn.1004-4221.2016.09.004

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Abstract Objective To investigate the incidence of adverse reactions in patients treated with postoperative adjuvant radiochemotherapy for esophageal carcinoma and its relationship with clinical factors. Methods Logistic regression was used for variate analyses on the incidence of radiation gastritis (RG), radiation pneumonia (RP), and marrow suppression in 49 patients with esophageal cancer who received postoperative adjuvant radiochemotherapy in 2014. Results In all the patients, 19(39%) patients had grade 2 RG, 7(14%) patients grade 2 RP, and 8(16%) patients grade 2 marrow suppression. The univariate analysis showed that the length of stomach was associated with the incidence of grade 2 RG (P=0.016);sex and the volume of stomach were associated with the incidence of grade 2 RP (P=0.026;P=0.047);≥2 cycles of chemotherapy were associated with the incidence of grade 2 marrow suppression (P=0.000). The multivariate analysis showed that the length of stomach was an independent factor for grade 2 RG (P=0.038) and the volume of stomach was an independent factor for grade 2 RP (P=0.013). Conclusions The postoperative state of the intrathoracic stomach affects the incidence of adverse reactions in patients with esophageal carcinoma. A longer stomach may cause higher incidence of grade 2 RG and a larger stomach may cause higher incidence of grade 2 RP.

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	Articles by authors
	Shen Wenbin
	Gao Hongmei
	Cao Yankun
	Zhu Shuchai
	Li Youmei
	Li Shuguang
	Li Juan
	Liu Zhikun
	Su Jingwei

Key words： Esophageal neoplasms/postoperative radiotherapy Esophageal neoplasms/postoperative chemotherapy Side effects Factor analysis

Received: 21 September 2015

Corresponding Authors: Zhu Shuchai,Email:sczhu1965@163.com

Cite this article:

Shen Wenbin,Gao Hongmei,Cao Yankun et al. A clinical analysis of adverse reactions of postoperative adjuvant radiochemotherapy for esophageal carcinoma[J]. Chinese Journal of Radiation Oncology, 2016, 25(9): 929-933.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2016.09.004 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2016/V25/I9/929

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