鼻咽癌螺旋断层放射治疗中颈部轮廓变化及相关因素分析

doi:10.3760/cma.j.cn113030-20220330-00116

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Abstract Objective To study the change pattern of neck diameter and relevant factors in nasopharyngeal carcinoma (NPC) patients treated with helical tomotherapy, aiming to provide reference for clinical practice. Methods Fifteen NPC patients treated with helical tomotherapy at Sun Yat-Sen University Cancer Center from November 2020 to February 2021 were enrolled in this study. The transverse diameters of NPC patients' neck contours and body weight of all patients during radiotherapy were recorded weekly. We used descriptive statistics to explore the distribution of transverse diameters of NPC patients' neck contours during radiotherapy. And Spearman correlation analysis was used to assess the association between weight loss and changes in neck contour transverse diameter. Results During radiotherapy, the distribution of transverse diameters of NPC patients' neck contours was completely different from the initial values. Specifically, the transverse diameters were significantly reduced at the 4th week of the radiotherapy. Moreover, the reduction of transverse diameter of neck contour was highly correlated with the weight loss (r=0.803, P<0.05), and moderately correlated with gender (r=0.523, P<0.05). However, there was no statistical correlation between the alteration of neck diameter and age, TNM stage, and the mean dose of GTV_nd-L, GTV_nd-R, PTV_nd-L and PTV_nd-R (all P>0.05). Conclusions The neck contours of NPC patients are altered regularly during helical tomotherapy, which are narrowed the most obviously in the 4th week. Extensive attention should be paid to the changes of neck contour during radiotherapy in clinical practice.

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	Articles by authors
	He Huilang
	Chen Shuxian
	Chen Xuanguang
	Zhang Zixian
	Liu Jindi
	Yao Wenyan
	Liu hui

Key words： Nasopharyngeal carcinoma Helical tomotherapy Neck

Received: 30 March 2022

Fund:; Fund program: Guangdong Medical Science and Technology Research Foundation (A2020621)

Corresponding Authors: Liu Hui, Email: liuhui2@sysucc.org.cn

Cite this article:

He Huilang,Chen Shuxian,Chen Xuanguang et al. Neck contour changes and relevant factors in nasopharyngeal carcinoma patients treated with helical tomotherapy[J]. Chinese Journal of Radiation Oncology, 2023, 32(2): 106-110.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20220330-00116 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2023/V32/I2/106

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