肝癌肺癌质子重离子治疗中主动呼吸控制技术不确定性研究

doi:10.3760/cma.j.cn113030-20210421-00168

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Abstract Objective To study and analyze the uncertainty of active breathing coordinator (ABC) technology for liver and lung cancer therapy using proton and heavy ion. Methods Before each treatment, each patient received a verification radiograph through the supporting imaging frame in treatment room. 200 verification radiographs were taken for 20 lung cancer patients and 200 for 20 liver cancer patients. Ipiodol markers, which were fixed relative to the location of the tumor, were injected into the liver cancer patients. The position changes of ipiodol markers could reflect the position changes of liver tumors. Verification radiographs were registered with the vertebral body as the main target, and the change value of tumor location was recorded. Results For liver cancer cases, the values of position change in the left and right, head and foot, and dorsal abdomendirection were (-0.05± 0.28) cm,(0.15±0.33) cm,(-0.12±0.27) cm,and (-0.03±0.13) cm,(-0.05±0.14) cm and (0.02±0.16) cmfor lung cancer cases, respectively (P=0.280,<0.001,<0.001). For liver cancer cases,the dispersionin the left and right, head and foot, and dorsal abdomendirectionwas (0.20±0.09) cm,(0.25±0.06) cm,(0.19±0.09) cm, and (0.09±0.03) cm,(0.10±0.03) cm and (0.13±0.03) cm for lung cancer cases,respectively (P<0.001,<0.001, 0.008). The proportion of tumor location changes of≤5mm in three directions in liver and lung cancer patientswas (92%, 83%, 93%) vs. (99%, 99%, 100%)(P=0.030, 0.002, 0.007). Conclusion The application of ABC technology in the proton heavy ion therapy of lung and liver cancer has good reproducibility, and the stability of ABC technology in the treatment of lung cancer is better than that of liver cancer.

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	Xie Wenbo
	Li Yongqiang

Key words： Liver neoplasm/proton and heavy ion therapy Lung neoplasm/proton and heavy ion therapy Active breathing coordinator Uncertainty

Received: 21 April 2021

Corresponding Authors: Li Yongqiang,Email:yongqiang.li@sphic.org.cn

Cite this article:

Xie Wenbo,Li Yongqiang. Uncertainty of active breathing coordinator technology for liver and lung cancer therapy using proton and heavy ion[J]. Chinese Journal of Radiation Oncology, 2022, 31(2): 187-191.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20210421-00168 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2022/V31/I2/187

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