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Clinical value of extramural vascular invasion in rectal cancer
Chen Silin1, Tang Yuan1, Jin Jing1,2
1Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China; 2Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China
Abstract Extramural vascular invasion (EMVI) is a prognostic factor in rectal cancer. The previous evaluation of EMVI relies on the analysis of postoperative pathological results. With the development of MRI, MRI can accurately assess the status of EMVI (mrEMVI).MrEMVI has become the important prognostic indicator for rectal cancer.The risk of local recurrence and distant metastasis in mrEMVI-positive patients will be significantly increased. The aim of this article is to review the diagnostic features, clinical significance, and impact on treatment patterns of EMVI, and project its future development trend of EMVI.
Fund:Capital Special Fund for Health Improvement and Scientific Research (2020-1-4021);Fundamental Research Fund for the Central Universities (3332019055);National Natural Science Foundation of China (81871509)
Corresponding Authors:
Jin Jing, Email:jinjing@csco.org.cn
Cite this article:
Chen Silin,Tang Yuan,Jin Jing. Clinical value of extramural vascular invasion in rectal cancer[J]. Chinese Journal of Radiation Oncology, 2021, 30(7): 748-752.
Chen Silin,Tang Yuan,Jin Jing. Clinical value of extramural vascular invasion in rectal cancer[J]. Chinese Journal of Radiation Oncology, 2021, 30(7): 748-752.
[1] Glynne-Jones R, Wyrwicz L, Tiret E, et al. Rectal cancer:ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up[J]. Ann Oncol, 2018, 29(Suppl 4):iv263. DOI:10.1093/annonc/mdy161. [2] Roxburgh CS, McMillan DC, Richards CH, et al. The clinical utility of the combination of T stage and venous invasion to predict survival in patients undergoing surgery for colorectal cancer[J]. Ann Surg, 2014, 259(6):1156-1165. DOI:10.1097/sla.0000000000000229. [3] Lino-Silva LS, Salcedo-Hernández RA, Espaáa-Ferrufino A, et al. Extramural perineural invasion in pT3 and pT4 rectal adenocarcinoma as prognostic factor after preoperative chemoradiotherapy[J]. Hum Pathol, 2017, 65:107-112. DOI:10.1016/j.humpath.2017.03.027. [4] Liu L, Liu M, Yang Z, et al. Correlation of MRI-detected extramural vascular invasion with regional lymph node metastasis in rectal cancer[J]. Clin Imaging, 2016, 40(3):456-460. DOI:10.1016/j.clinimag.2016.01.007. [5] Benson AB, Venook AP, Al-Hawary MM, et al. Rectal cancer, version 2.2018, NCCN Clinical Practice Guidelines in Oncology[J]. J Natl Compr Canc Netw, 2018, 16(7):874-901. DOI:10.6004/jnccn.2018.0061. [6] Cote A, Florin FG, Mois E, et al. The accuracy of endorectal ultrasonography and high-resolution magnetic resonance imaging for restaging rectal cancer after neoadjuvant chemoradiotherapy[J]. Ann Ital Chir, 2018, 89:168-176. [7] Moreno CC, Sullivan PS, Mittal PK. MRI evaluation of rectal cancer:staging and restaging[J]. Curr Probl Diagn Radiol, 2017, 46(3):234-241. DOI:10.1067/j.cpradiol.2016.11.011. [8] Talbot IC, Ritchie S, Leighton M, et al. Invasion of veins by carcinoma of rectum:method of detection, histological features and significance[J]. Histopathology, 1981, 5(2):141-163. DOI:10.1111/j.1365-2559.1981.tb01774.x. [9] Betge J, Pollheimer MJ, Lindtner RA, et al. Intramural and extramural vascular invasion in colorectal cancer:prognostic significance and quality of pathology reporting[J]. Cancer, 2012, 118(3):628-638. DOI:10.1002/cncr.26310. [10] Leijssen LGJ, Dinaux AM, Amri R, et al. Impact of intramural and extramural vascular invasion on stage Ⅱ-Ⅲ colon cancer outcomes[J]. J Surg Oncol, 2019, 119(6):749-757. DOI:10.1002/jso.25367. [11] Lim SB, Yu CS, Jang SJ, et al. Prognostic significance of lymphovascular invasion in sporadic colorectal cancer[J]. Dis Colon Rectum, 2010, 53(4):377-384. DOI:10.1007/DCR.0b013e3181cf8ae5. [12] Kirsch R, Assarzadegan N, Messenger DE, et al. The impact of knowledge transfer on the detection of venous invasion in colorectal cancer[J]. Hum Pathol, 2017, 67:45-53. DOI:10.1016/j.humpath.2017.07.004. [13] Kirsch R, Messenger DE, Riddell RH, et al. Venous invasion in colorectal cancer:impact of an elastin stain on detection and interobserver agreement among gastrointestinal and nongastrointestinal pathologists[J]. Am J Surg Pathol, 2013, 37(2):200-210. DOI:10.1097/PAS.0b013e31826a92cd. [14] Shepherd Mblpqna. Standards and datasets for reporting cancers Dataset for histopathological reporting of colorectal cancer September 2018[R]. London:The Royal College of Pathologists, 2019. [15] Dresen RC, Peters EE, Rutten HJ, et al. Local recurrence in rectal cancer can be predicted by histopathological factors[J]. Eur J Surg Oncol, 2009, 35(10):1071-1077. DOI:10.1016/j.ejso.2009.03.007. [16] Mori D, Shibaki M, Masuda M, et al. Quantitative measurement of venous invasion of colorectal cancer with metachronous liver metastasis[J]. Histopathology, 2009, 55(6):654-659. DOI:10.1111/j.1365-2559.2009.03428.x. [17] Brown G, Radcliffe AG, Newcombe RG, et al. Preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imaging[J]. Br J Surg, 2003, 90(3):355-364. DOI:10.1002/bjs.4034. [18] Smith NJ, Barbachano Y, Norman AR, et al. Prognostic significance of magnetic resonance imaging-detected extramural vascular invasion in rectal cancer[J]. Br J Surg, 2008, 95(2):229-236. DOI:10.1002/bjs.5917. [19] Bae JS, Kim SH, Hur BY, et al. Prognostic value of MRI in assessing extramural venous invasion in rectal cancer:multi-readers′ diagnostic performance[J]. Eur Radiol, 2019, 29(8):4379-4388. DOI:10.1007/s00330-018-5926-9. [20] Koh DM, Smith NJ, Swift RI, et al. The Relationship between MR demonstration of extramural venous invasion and nodal disease in rectal cancer[J]. Clin Med Oncol, 2008, 2:267-273. DOI:10.4137/CMO. S370. [21] Jhaveri KS, Hosseini-Nik H, Thipphavong S, et al. MRI detection of extramural venous invasion in rectal cancer:correlation with histopathology using elastin stain[J]. AJR Am J Roentgenol, 2016, 206(4):747-755. DOI:10.2214/AJR.15.15568. [22] Chand M, Evans J, Swift RI, et al. The prognostic significance of postchemoradiotherapy high-resolution MRI and histopathology detected extramural venous invasion in rectal cancer[J]. Ann Surg, 2015, 261(3):473-479. DOI:10.1097/sla.0000000000000848. [23] Fornell-Perez R, Vivas-Escalona V, Aranda-Sanchez J, et al. Primary and post-chemoradiotherapy MRI detection of extramural venous invasion in rectal cancer:the role of diffusion-weighted imaging[J]. Radiol Med, 2020, 125(6):522-530. DOI:10.1007/s11547-020-01137-7. [24] Zhang XY, Wang S, Li XT, et al. MRI of extramural venous invasion in locally advanced rectal cancer:relationship to tumor recurrence and overall survival[J]. Radiology, 2018, 289(3):677-685. DOI:10.1148/radiol.2018172889. [25] Battersby NJ, How P, Moran B, et al. Prospective validation of a low rectal cancer magnetic resonance imaging staging system and development of a local recurrence risk stratification model:the MERCURY Ⅱ study[J]. Ann Surg, 2016, 263(4):751-760. DOI:10.1097/sla.0000000000001193. [26] Sohn B, Lim JS, Kim H, et al. MRI-detected extramural vascular invasion is an independent prognostic factor for synchronous metastasis in patients with rectal cancer[J]. Eur Radiol, 2015, 25(5):1347-1355. DOI:10.1007/s00330-014-3527-9. [27] Bugg WG, Andreou AK, Biswas D, et al. The prognostic significance of MRI-detected extramural venous invasion in rectal carcinoma[J]. Clin Radiol, 2014, 69(6):619-623. DOI:10.1016/j.crad.2014.01.010. [28] Siddiqui MRS, Simillis C, Hunter C, et al. A meta-analysis comparing the risk of metastases in patients with rectal cancer and MRI-detected extramural vascular invasion (mrEMVI) vs. mrEMVI-negative cases[J]. Br J Cancer, 2017, 116(12):1513-1519. DOI:10.1038/bjc.2017.99. [29] Prampolini F, Taschini S, Pecchi A, et al. Magnetic resonance imaging performed before and after preoperative chemoradiotherapy in rectal cancer:predictive factors of recurrence and prognostic significance of MR-detected extramural venous invasion[J]. Abdom Radiol (NY), 2020, 45(10):2941-2949. DOI:10.1007/s00261-018-1838-z. [30] Chand M, Swift RI, Tekkis PP, et al. Extramural venous invasion is a potential imaging predictive biomarker of neoadjuvant treatment in rectal cancer[J]. Br J Cancer, 2014, 110(1):19-25. DOI:10.1038/bjc.2013.603. [31] Dewdney A, Cunningham D, Tabernero J, et al. Multicenter randomized phase Ⅱ clinical trial comparing neoadjuvant oxaliplatin, capecitabine, and preoperative radiotherapy with or without cetuximab followed by total mesorectal excision in patients with high-risk rectal cancer (EXPERT-C)[J]. J Clin Oncol, 2012, 30(14):1620-1627. DOI:10.1200/jco.2011.39.6036. [32] Gollins S, West N, Sebag-Montefiore D, et al. A prospective phase Ⅱ study of pre-operative chemotherapy then short-course radiotherapy for high risk rectal cancer:COPERNICUS[J]. Br J Cancer, 2018, 119(6):697-706. DOI:10.1038/s41416-018-0209-4. [33] Wang X, Yu Y, Meng W, et al. Total neoadjuvant treatment (CAPOX plus radiotherapy) for patients with locally advanced rectal cancer with high risk factors:a phase 2 trial[J]. Radiother Oncol, 2018, 129(2):300-305. DOI:10.1016/j.radonc.2018.08.027. [34] Kokelaar RF, Jones HG, Williamson J, et al. DNA hypermethylation as a predictor of extramural vascular invasion (EMVI) in rectal cancer[J]. Cancer Biol Ther, 2018, 19(3):214-221. DOI:10.1080/15384047.2017.1416933. [35] Jiang H, Sun L, Hu C, et al. Hypermethylated WNT10A and its clinical significance in colorectal cancer[J]. Am J Transl Res, 2018, 10(12):4290-4301. [36] Luo Y, Cheng B, Liu S, et al. Relationship between CpG island methylation phenotype, microsatellite instability phenotype and mutation of KRAS, NRAS, and BRAF genes in colorectal cancer[J]. Int J Clin Exp Pathol, 2019, 12(3):1101-1107. [37] Williamson JS, Jones HG, Williams N, et al. Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer:Influence of the CpG island methylator phenotype[J]. World J Gastrointest Oncol, 2017, 9(5):209-217. DOI:10.4251/wjgo.v9.i5.209. [38] Li XF, Jiang Z, Gao Y, et al. Combination of three-gene immunohistochemical panel and magnetic resonance imaging-detected extramural vascular invasion to assess prognosis in non-advanced rectal cancer patients[J]. World J Gastroenterol, 2016, 22(38):8576-8583. DOI:10.3748/wjg.v22.i38.8576.