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Chinese Journal of Radiation Oncology  2019, Vol. 28 Issue (1): 23-26    DOI: 10.3760/cma.j.issn.1004-4221.2019.01.005
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Study on the correlation between acute radionuclitidis and improved body mass index in intensity-modulated radiation therapy after cervical cancer surgery
Chen Enle1, Yang Wan2, Gu Jiale3, Zhang Ke3, Deng Qinghua3, Ma Shenglin3, Li Xiadong3,4
1Department of Radiation Technology,Wenzhou Central Hospital,Wenzhou 325000,China;
2Department of Radiation Radiology,Wenzhou Central Hospital,Wenzhou 325000,China;
3Department of Radiation Oncology,Hangzhou First People' Hospital,Hangzhou Cancer Hospital,Hangzhou 310000,China;
4Sir Run Run Shaw Hospital,Zhejiang University School of Medicine;Institute of Translational Medicine,Zhejiang University,Hangzhou Cancer Hospital, 310000,China;
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Abstract   Objective To investigate the relationship between the body mass index (BMI)/ body mass index improved (BMIIMPd) and the dose of the small intestine as well as the acute radiation colitis in the intensity-modulated radiation therapy after cervical cancer surgery. Methods Thirty-nine cervical cancer patients underwent postoperative adjuvant radiotherapy. All patients received Philips large bore CT scan for enhanced CT scan,target delineation and organ at risk. All patients were treated with a single arc 10 MV VMAT plan. The correlation between the radiation dose of the small intestine and the acute radiation enteritis and BMI/BMIIMPd was analyzed. Results The BMI was calculated as (22.23±2.80) kg/m2,BMIIMPd was (21.49±3.95) kg/m2,the small intestine volume VSI was (1 155.71 ± 419.33 )cc3. The volume of the small intestine received more than 10 Gy(V10_SI) VMAT was (66.50±27.01)%,and the equivalent uniform dose (EUD) and normal tissue complication probability (NTCP) were (4098.87±184.93) cGy and (7.98±8.73)%. One way ANOVA demonstrated that under the VMAT technology,the BMIIMPd,V30,V40,EUD (α=50) and NTCP in the small intestine were the influencing factors of the occurrence of acute radiation enteritis. Conclusions If the improved BMIIMPd is utilized to distinguish the BMI,the high dose area of the small intestine will be larger and the incidence of acute radiation enteritis will be higher for patients with BMIIMPd between 10.1 and 16.9(normal and thin). Conventional BMI cannot be utilized as a basis for the prediction of the incidence of acute radiation enteritis in patients with cervical carcinoma.
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Articles by authors
Chen Enle
Yang Wan
Gu Jiale
Zhang Ke
Deng Qinghua
Ma Shenglin
Li Xiadong
Key words Cervical neoplasms/radiotherapy      Acute radiation enteritis      Body mass index     
Received: 14 March 2018     
Fund:Wenzhou Science and Technology Project (Y20140313)
Corresponding Authors: Li Xiadong,Email:hehe8812@126.com   
Cite this article:   
Chen Enle,Yang Wan,Gu Jiale et al. Study on the correlation between acute radionuclitidis and improved body mass index in intensity-modulated radiation therapy after cervical cancer surgery[J]. Chinese Journal of Radiation Oncology, 2019, 28(1): 23-26.
Chen Enle,Yang Wan,Gu Jiale et al. Study on the correlation between acute radionuclitidis and improved body mass index in intensity-modulated radiation therapy after cervical cancer surgery[J]. Chinese Journal of Radiation Oncology, 2019, 28(1): 23-26.
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