基于磁纳米材料的磁热疗抗肿瘤研究进展

doi:10.3760/cma.j.cn113030-20211125-00483

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Abstract Thermotherapy has become another important tumor treatment after surgery, radiotherapy, chemotherapy, and targeted treatment. Magnetic hyperthermia (MH) is a new type of hyperthermia, which has attracted widespread attention due to its advantages of non-invasiveness / minimal invasiveness, high efficiency and good tissue penetration. It provides a new option for the molecular level treatment of malignant tumors with high efficacy and low toxicity, which has become a new research direction of tumor treatment. Magnetic materials and suitable magnetic fields are needed to realize MH. Iron oxide nanoparticles (IONs) are widely studied as MH agents because of their high biocompatibility and heating ability. In this article, the research progress on magnetic iron oxide nanomaterials and MH combined with antitumor therapy based on magnetic nanoparticles were analyzed, and the potential application of MH in cancer treatment was reviewed.

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	Articles by authors
	Xia Jindan
	Wu Zhibing
	Lan Kaiping

Key words： Magnetic nanomaterials Magnetic hyperthermia Neoplasm therapeutics Synergistic treatment

Received: 25 November 2021

Fund:; Fund programs: National Natural Science Foundation of China (82172679); Zhejiang Province Medical Science and Technology Project (2021KY010); Hangzhou Science and Technology Development Project (20171226Y223)

Corresponding Authors: Wu Zhibing, Email: wu_zhibing@163.com

Cite this article:

Xia Jindan,Wu Zhibing,Lan Kaiping. Research progress of magnetic hyperthermia based on magnetic nanomaterials[J]. Chinese Journal of Radiation Oncology, 2023, 32(2): 164-168.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20211125-00483 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2023/V32/I2/164

[1] Zhu ST, He M, Yang GL, et al. The latest research progress of magnetic hyperthermia[J]. J Shanghai Normal University (Natural Sciences), 2019,48(5):536-549. DOI: 10.3969/J.ISSN.1000-5137.2019.05.011.
[2] 谢俊, 陈玲, 严长志, 等. 肿瘤靶向热疗用磁性纳米材料[J].中国材料进展,2016,35(8):561-568. DOI: 10.7502/j.issn.1674-3962.2016.08.01.
Xie J, Chen L, Yan CZ, et al.Application of magnetic nanoparticles for tumor-targeting hyperthemia[J].2016,35(8):561-568. DOI: 10.7502/j.issn.1674-3962.2016. 08.01.
[3] Spirou SV, Basini M, Lascialfari A, et al.Magnetic hyperthermia and radiation therapy: radiobiological principles and current practice^†[J]. Nanomaterials (Basel), 2018,8(6):401. DOI: 10.3390/nano8060401.
[4] Fatima H, Charinpanitkul T, Kim KS.Fundamentals to apply magnetic nanoparticles for hyperthermia therapy[J]. Nanomaterials (Basel), 2021,11(5):1203. DOI: 10.3390/nano11051203.
[5] Sun T, Zhang YS, Pang B, et al.Engineered nanoparticles for drug delivery in cancer therapy[J]. Angew Chem Int Ed Engl, 2014,53(46):12320-12364. DOI: 10.1002/anie. 201403036.
[6] Ahamed M, Akhtar MJ, Alhadlaq HA, et al.Copper ferrite nanoparticle-induced cytotoxicity and oxidative stress in human breast cancer MCF-7 cells[J]. Colloids Surf B Biointerfaces, 2016,142:46-54. DOI: 10.1016/j.colsurfb. 2016.02.043.
[7] Jacinto MJ, Silva VC, Valladão D, et al.Biosynthesis of magnetic iron oxide nanoparticles: a review[J]. Biotechnol Lett, 2021,43(1):1-12. DOI: 10.1007/s10529- 020-03047-0.
[8] Maier-Hauff K, Rothe R, Scholz R, et al.Intracranial thermotherapy using magnetic nanoparticles combined with external beam radiotherapy: results of a feasibility study on patients with glioblastoma multiforme[J]. J Neurooncol, 2007,81(1):53-60. DOI: 10.1007/s11060- 006-9195-0.
[9] Borges R, Mendonça-Ferreira L, Rettori C, et al.New sol-gel-derived magnetic bioactive glass-ceramics containing superparamagnetic hematite nanocrystals for hyperthermia application[J]. Mater Sci Eng C Mater Biol Appl, 2021,120:111692. DOI: 10.1016/j.msec.2020. 111692.
[10] Périgo EA, Hemery G, Sandre O, et al.Fundamentals and advances in magnetic hyperthermia[J]. Appl Phys Rev, 2015. DOI: 10.1063/1.4935688.
[11] Smolkova IS, Kazantseva NE, Babayan V, et al.The role of diffusion-controlled crowth in the formation of uniform iron oxide nanoparticles with a link to magnetic hyperthermia[J]. Cryst Growth Des, 2017,17(5):2323-2332. DOI: 10.1021/acs.cgd.6b01104.
[12] Kandasamy G, Khan S, Giri J, et al. One-pot synthesis of hydrophilic flower-shaped iron oxide nanoclusters (IONCs) based ferrofluids for magnetic fluid hyperthermia applications[J]. J Mol Liq, 2019,275:699-712. DOI: 10.1016/j.molliq.2018.11.108.
[13] Matsumi Y, Kagawa T, Yano S, et al.Hyperthermia generated by magnetic nanoparticles for effective treatment of disseminated peritoneal cancer in an orthotopic nude-mouse model[J]. Cell Cycle, 2021,20(12):1122-1133. DOI: 10.1080/15384101.2021.1919441.
[14] Plan Sangnier A, Preveral S, Curcio A, et al.Targeted thermal therapy with genetically engineered magnetite magnetosomes@RGD: photothermia is far more efficient than magnetic hyperthermia[J]. J Control Release, 2018,279:271-281. DOI: 10.1016/j.jconrel.2018.04.036.
[15] Liu XL, Yang Y, Ng CT, et al.Magnetic vortex nanorings: a new class of hyperthermia agent for highly efficient in vivo regression of tumors[J]. Adv Mater, 2015,27(11):1939-1944. DOI: 10.1002/adma.201405036.
[16] Dias C, Hanchuk T, Wender H, et al.Shape tailored magnetic nanorings for intracellular hyperthermia cancer therapy[J]. Sci Rep, 2017,7(1):14843. DOI: 10.1038/s41598-017-14633-0.
[17] Liu X, Yan B, Li Y, et al.Graphene oxide-grafted magnetic nanorings mediated magnetothermodynamic therapy favoring reactive oxygen species-related immune response for enhanced antitumor efficacy[J]. ACS Nano, 2020,14(2):1936-1950. DOI: 10.1021/acsnano.9b08320.
[18] Lei Z, Zhang Y, Liu G. eMIONs: novel genetically engineered nanocages for magnetic hyperthermia cancer therapy[J]. Mol Cell Oncol, 2021,8(1):1863739. DOI: 10.1080/23723556.2020.1863739.
[19] Eivazzadeh-Keihan R, Asgharnasl S, Bani MS, et al.Magnetic copper ferrite nanoparticles functionalized by aromatic polyamide chains for hyperthermia applications[J]. Langmuir, 2021,37(29):8847-8854. DOI: 10.1021/acs.langmuir.1c01251.
[20] Jiang PS, Tsai HY, Drake P, et al.Gadolinium-doped iron oxide nanoparticles induced magnetic field hyperthermia combined with radiotherapy increases tumour response by vascular disruption and improved oxygenation[J]. Int J Hyperthermia, 2017,33(7):770-778. DOI: 10.1080/02656736.2017.1308019.
[21] Lin M, Zhang D, Huang J, et al.The anti-hepatoma effect of nanosized Mn-Zn ferrite magnetic fluid hyperthermia associated with radiation in vitro and in vivo[J]. Nanotechnology, 2013,24(25):255101. DOI: 10.1088/0957-4484/24/25/255101.
[22] Wang Y, Zou L, Qiang Z, et al.Enhancing targeted cancer treatment by combining hyperthermia and radiotherapy using Mn-Zn ferrite magnetic nanoparticles[J]. ACS Biomater Sci Eng, 2020,6(6):3550-3562. DOI: 10.1021/acsbiomaterials.0c00287.
[23] Khoei S, Hosseini V, Hosseini M, et al.Enhancement of radio-thermo-sensitivity of 5-iodo-2-deoxyuridine-oaded polymeric-coated magnetic nanoparticles triggers apoptosis in U87MG human glioblastoma cancer cell line[J]. Cell Mol Bioeng, 2021,14(4):365-377. DOI: 10.1007/s12195-021-00675-y.
[24] Attaluri A, Kandala SK, Wabler M, et al.Magnetic nanoparticle hyperthermia enhances radiation therapy: a study in mouse models of human prostate cancer[J]. Int J Hyperthermia, 2015,31(4):359-374. DOI: 10.3109/02656736.2015.1005178.
[25] Liu S, Shi D, Chen L, et al.Paclitaxel-loaded magnetic nanocrystals for tumor neovascular-targeted theranostics: an amplifying synergistic therapy combining magnetic hyperthermia with chemotherapy[J]. Nanoscale, 2021,13(6):3613-3626. DOI: 10.1039/d0nr08197c.
[26] Fernandes S, Fernandez T, Metze S, et al.Magnetic nanoparticle-based hyperthermia mediates drug delivery and impairs the tumorigenic capacity of quiescent colorectal cancer stem cells[J]. ACS Appl Mater Interfaces, 2021,13(14):15959-15972. DOI: 10.1021/acsami.0c21349.
[27] Das S, Johnson DB.Immune-related adverse events and anti-tumor efficacy of immune checkpoint inhibitors[J]. J Immunother Cancer, 2019,7(1):306. DOI: 10.1186/s40425-019-0805-8.
[28] Stephen ZR, Zhang M.Recent progress in the synergistic combination of nanoparticle-mediated hyperthermia and immunotherapy for treatment of cancer[J]. Adv Healthc Mater, 2021,10(2):e2001415. DOI: 10.1002/adhm. 202001415.
[29] Liu X, Zheng J, Sun W, et al.Ferrimagnetic vortex nanoring-mediated mild magnetic hyperthermia imparts potent immunological effect for treating cancer metastasis[J]. ACS Nano, 2019,13(8):8811-8825. DOI: 10.1021/acsnano.9b01979.