中华放射肿瘤学杂志
Saturday, Apr. 5, 2025   Home | Journal | Editorial | Instruction | Subscription | Advertisement | Academic | Index-in | Contact Us | Chinese
Chinese Journal of Radiation Oncology  2023, Vol. 32 Issue (2): 118-123    DOI: 10.3760/cma.j.cn113030-20211122-00480
Thoracic Tumor Current Issue| Next Issue| Archive| Adv Search [an error occurred while processing this directive] | [an error occurred while processing this directive]
Clinical efficacy and toxic effects of prophylactic cranial irradiation in non-small cell lung cancer: a meta-analysis
Huang Shengkai, Zhang Huiliang, Feng Nan
Department of Thoracic Surgery, Central Hospital of Xinyu Iron & Steel Group, Xinyu 338000, China
Download: PDF (0 KB)   HTML (1 KB) 
Export: BibTeX | EndNote (RIS)      Supporting Info
Abstract  Objective To investigate the role of prophylactic cranial irradiation (PCI) in non-small cell lung cancer (NSCLC) by meta-analysis. Methods Studies published from January 1, 1980 to August 30, 2021 were searched systematically in PubMed, Embase, Cochrane Systematic Review database and China National Knowledge Infrastructure Database. The searching keywords included "non-small cell lung cancer", "randomized controlled trial", "prophylactic cranial irradiation" and "clinical trial". The data extracted from the above studies were analyzed using Review Manager 5.3 and Stata 12.0 software. Outcomes included the development of brain metastases (BM), overall survival (OS), disease-free survival (DFS), toxicity, and quality of life (QoL). Results Ten trials, including 2005 NSCLC patients, met the inclusion criteria. Patients who underwent PCI had a significantly lower risk of BM than those who did not (OR=0.29, 95%CI: 0.22-0.40, P<0.001). Compared with non-PCI group, DFS in PCI group was significantly increased (HR=0.75, 95%CI: 0.63-0.89, P=0.001). However, there was no significant difference in OS (OR=0.90, 95%CI: 0.69-1.18, P=0.45). In addition, the incidence of fatigue was significantly increased in the PCI group (OR=2.64, 95%CI: 1.58-4.40, P<0.001). There was no significant difference in cognitive impairment between the PCI and non-PCI groups (OR=3.60, 95%CI: 0.97-13.32, P=0.06). Conclusions PCI is the standard treatment for NSCLC. Compared with non-PCI, PCI significantly reduces the incidence of BM and prolongs the DFS of NSCLC patients. The effect of PCI-related toxicity on the QoL and long-term OS needs further study.
Service
E-mail this article
Add to my bookshelf
Add to citation manager
E-mail Alert
RSS
Articles by authors
Huang Shengkai
Zhang Huiliang
Feng Nan
Key wordsBrain metastases      Disease-free survival      Carcinoma,non-small cell lung      Overall survival      Prophylactic cranial irradiation      Quality of life      Toxicity     
Received: 22 November 2021     
Corresponding Authors: Feng Nan, Email: feng971123@163.com   
Cite this article:   
Huang Shengkai,Zhang Huiliang,Feng Nan. Clinical efficacy and toxic effects of prophylactic cranial irradiation in non-small cell lung cancer: a meta-analysis[J]. Chinese Journal of Radiation Oncology, 2023, 32(2): 118-123.
Huang Shengkai,Zhang Huiliang,Feng Nan. Clinical efficacy and toxic effects of prophylactic cranial irradiation in non-small cell lung cancer: a meta-analysis[J]. Chinese Journal of Radiation Oncology, 2023, 32(2): 118-123.
URL:  
http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20211122-00480     OR     http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2023/V32/I2/118
  Copyright © 2010 Editorial By Chinese Journal of Radiation Oncology
Support by Beijing Magtech Co.ltd  support@magtech.com.cn