中华放射肿瘤学杂志
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Chinese Journal of Radiation Oncology  2022, Vol. 31 Issue (5): 478-482    DOI: 10.3760/cma.j.cn113030-20200710-00354
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Research progress on high-dose-rate brachytherapy of localized prostate cancer
Guo Wei, Sun Yunchuan
Department of Radiation Oncology, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China
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Abstract  Brachytherapy has played an important role in localized prostate cancer. High-dose-rate brachytherapy has evolved over the decades, as either monotherapy or in combination with external beam, it offers many advantages over other treatment alternatives. Precise control over dose delivery allows for focal dose escalation while sculpting dose around organs at risk to maintain excellent tolerance. The high dose per fraction exploits the low α/β ratio of prostate cancer and triggers transcriptional changes in the tumor genome, thereby enhancing radiation sensitivity. In this article, the development, patient selection, application of techniques, clinical efficacy and adverse events for high-dose-rate brachytherapy were summarized.
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Guo Wei
Sun Yunchuan
Key wordsProstatic neoplasms      Brachytherapy      High-dose rate      Clinical efficacy     
Received: 10 July 2020     
Fund:2021 Cangzhou Science and Technology Project Self-financing Project (213106092)
Corresponding Authors: Sun Yunchuan, Email:sunyunchuan@163.com   
Cite this article:   
Guo Wei,Sun Yunchuan. Research progress on high-dose-rate brachytherapy of localized prostate cancer[J]. Chinese Journal of Radiation Oncology, 2022, 31(5): 478-482.
Guo Wei,Sun Yunchuan. Research progress on high-dose-rate brachytherapy of localized prostate cancer[J]. Chinese Journal of Radiation Oncology, 2022, 31(5): 478-482.
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