EGFR敏感突变非小细胞肺癌脑转移患者临床特征综述

doi:10.3760/cma.j.cn113030-20200921-00474

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Abstract Advanced non-small cell lung cancer (NSCLC) patients are commonly with brainmetastases, leading to poor survival and quality of life. Epidermal growth factor receptor (EGFR) is common sensitive mutation type in NSCLC. Compared with other molecular types, it has different molecular biological characteristics. For patients with brain metastases and EGFR-mutated advanced NSCLC, EGFR-tyrosine kinase inhibitors can prolong overall survival and improve intracranial and extracranial control rate. To understand the characteristics of brain metastases of patients with sensitively EGFR-mutated NSCLC, the incidence, onset time, site, number and size of lesions, symptoms, targeted treatment effect and disease outcomes were reviewed, which can provide reference for interventional timing and local treatment technology selection of local treatment for brain parenchymal metastases.

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	Articles by authors
	Zhu Yixiang
	Zhang Ye

Key words： Carcinoma, non-small-cell lung Brain metastasis Epidermal growth factor receptor Clinical feature

Received: 21 September 2020

Corresponding Authors: Zhang Ye, Email:drzye1983@163.com

Cite this article:

Zhu Yixiang,Zhang Ye. Clinical features of patients with EGFR mutation-positive non-small cell lung cancer and brain metastases[J]. Chinese Journal of Radiation Oncology, 2022, 31(5): 468-472.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20200921-00474 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2022/V31/I5/468

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