成釉细胞瘤预后评估——基于SEER数据库的研究

doi:10.3760/cma.j.cn113030-20200615-00307

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Abstract Objective Ameloblastoma (AM) is a rare tumor derived from dental epithelial tissues, which is prone to recurrence and infiltration. This study aims to identify the prognostic factors of AM. Methods 207 ameloblastoma patients were screened from the SEER database. A Cox regression model and nomogram were constructed to evaluate the factors on the overall survival. Clinical data of 61 patients admitted to Hunan Cancer Hospital were retrospectively analyzed. The independent factors of recurrence rate were analyzed by the Cox regression model. Results The results on the SEER database showed that age, tumor size, type of surgery, radiotherapy were important prognostic factors of the overall survival. The nomogram was constructed and the C-index was equaled to 0.821, indicating this model was moderately accurate. The receiver operating characteristic (ROC) curve demonstrated that the area under the ROC curve (AUC) at 1, 3, 5, and 10 years were 0.852, 0.869, 0.856, and 0.879, indicating this model had relatively high sensitivity and specificity. Kaplan-Meier survival analysis suggested that overall survival in the high-risk group was significantly lower than that in the low-risk group (P<0.001). Based on retrospective analysis, clinical symptoms and type of surgery were the independent factors of the local recurrence rate. Kaplan-Meier survival analysis found the recurrence rate of facial swelling and pain was lower compared to those of other symptoms. Compared with the palliative surgery, radical surgery could decrease the recurrence rate. Conclusions Age, tumor size, type of surgery, and radiotherapy may be important factors of the overall survival. Type of surgery and clinical symptoms are probably the independent factors of the recurrence rate.

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	Articles by authors
	Jin Yi
	Yang Pei
	Jin Hekun
	Han Yaqian
	Wu Xiangwei
	Wang Hui

Key words： Ameloblastoma Prognosis SEER database Nomogram

Received: 15 June 2020

Fund:Key Laboratory of Translational Radiation Oncology of Hunan Province (2015TP1009);Key Research and Development Program of Hunan Province (2018SK2123);Hunan Cancer Hospital Climb Plan (QH201905)

Corresponding Authors: Wang Hui, Email: wanghui710327@163.com

Cite this article:

Jin Yi,Yang Pei,Jin Hekun et al. Prognosis evaluation of ameloblastoma—A study based on SEER database[J]. Chinese Journal of Radiation Oncology, 2021, 30(7): 659-664.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20200615-00307 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2021/V30/I7/659

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