基于经验计划的VMAT和IMRT模型预测前列腺IMRT剂量分布的对比研究

doi:10.3760/cma.j.cn113030-20190514-00179

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Abstract Objective To compare the dosimetric difference between knowledge-based planning (KBP) volumetric modulated arc therapy (VMAT) and intensity-modulated radiotherapy (IMRT) models for predicting the dose distribution during IMRT, aiming to investigate the feasibility of VMAT model to predict the IMRT plans. Methods Fifty prostate cancer patients who had completed radiotherapy were selected. Manual planning was performed on each selected patient to generate the corresponding IMRT and VMAT plans. The IMRT and VMAT manual plans of the 40 randomly-selected patients were adopted to generate the KBP VMAT and IMRT models. The remaining 10 patients were utilized to predict IMRT plans. VMAT library-derived IMRT model (V-IMRT) and IMRT library-derived IMRT model (I-IMRT) were generated. Dosimetric parameters related to organ-at-risks (OARs) and planning target volume (PTV) were statistically compared among the manual IMRT (mIMRT), V-IMRT and I-IMRT plans. Results Compared with the mIMRT plan, I-IMRT could significantly better control Dmax of the PTV (P=0.039), whereas V-IMRT and I-IMRT plans could better protect the bladder and bilateral femoral heads (both P<0.05). V-IMRT plan could better protect the Dmax of bilateral femoral heads and the D15% of the right femoral head (both P<0.05), whereas no significant difference was observed in other OARs and PTV (all P>0.05). Conclusions Compared with the manual plans, KBP IMRT plan has significant advantages in protecting the OARs. KBP VMAT and IMRT models are both feasible in clinical practice, which yield equivalent accuracy for predicting IMRT plan.

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	Articles by authors
	Bi Suyan
	Dai Zhitao
	Ding Zhen
	Sun Xingru
	Yuan Qingqing
	Chen Zhijian
	Ren Hua

Key words： Knowledge-based planning Model prediction Prostate neoplasm/radiotherapy

Received: 14 May 2019

Fund:Cancer Hospital Chinese Academy of Medical Sciences, Prof. Lyuhua Wang Radiotherapy Team (SZSM201612063)

Corresponding Authors: Ren Hua, Email:renhua2009@hotmail.com

Cite this article:

Bi Suyan,Dai Zhitao,Ding Zhen et al. A comparative study of dose distribution of prostate IMRT between IMRT and VMAT models using knowledge-based planning[J]. Chinese Journal of Radiation Oncology, 2021, 30(2): 164-169.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20190514-00179 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2021/V30/I2/164

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