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Chinese Journal of Radiation Oncology  2021, Vol. 30 Issue (12): 1335-1339    DOI: 10.3760/cma.j.cn113030-20200323-00127
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Research progress on epigenetics in the repair of radiation-induced DNA damage in tumors
Jie Xiaohua, Xu Shuangbing, Wu Gang
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, China
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Abstract  Radiotherapy kills tumor cells by radiation-induced DNA double-strand breaks (DSB), however, abnormal DSB repair in tumor cells often leads to radioresistance, in which epigenetics plays an important role. Targeting aberrant epigenetic markers may be a potential means of cancer radiosensitization, but the clinical application of the combination of epigenetic drugs and radiotherapy requires further investigation. This article reviews the latest research progress the role of epigenetics in the repair of radiation-induced DNA damage in tumors.
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Articles by authors
Jie Xiaohua
Xu Shuangbing
Wu Gang
Key wordsEpigenetics      Radiation-induced DNA damage repair      Neoplasms/radiotherapy     
Received: 23 March 2020     
Fund:National Natural Science Foundation of China (81874218)
Corresponding Authors: Wu Gang, Email:xhzlwg@163.com   
Cite this article:   
Jie Xiaohua,Xu Shuangbing,Wu Gang. Research progress on epigenetics in the repair of radiation-induced DNA damage in tumors[J]. Chinese Journal of Radiation Oncology, 2021, 30(12): 1335-1339.
Jie Xiaohua,Xu Shuangbing,Wu Gang. Research progress on epigenetics in the repair of radiation-induced DNA damage in tumors[J]. Chinese Journal of Radiation Oncology, 2021, 30(12): 1335-1339.
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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20200323-00127     OR     http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2021/V30/I12/1335
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