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Chinese Journal of Radiation Oncology  2020, Vol. 29 Issue (7): 535-539    DOI: 10.3760/cma.j.cn113030-20190603-00208
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Application of cervix-uterine ITV in volumetric modulated arc therapy for cervical cancer under different bladder filling status
Ma Jianping, Pan Wenyan, Xia Xinshe, Ye Hongqiang, He Jianli, Bai Xuehong, Feng Yangyang, Kong Wei, Jin Xiaofeng, Zhao Ren
Department of Radiation Oncology, Ningxia Medical University General Hospital, Tumor Hospital, Yinchuan 750004, China
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Abstract  Objective To investigate the clinical application of cervix-uterine internal target volume (ITV) in volume-modulated arc therapy (VMAT) for cervical cancer under different bladder filling conditions, aiming to obtain more accurate planning target volume (PTV). Methods Sixty-two patients with cervical cancer receiving radiotherapy rather than surgery were selected and randomly divided into the study (n=31) and control groups (n=31). In the study group, individualized ITV, PTV and PTV margin were obtained under three bladder filling status by localization CT scan to compare the VMAT. The target area and organs at risk (OARs) within the target area were statistically compared between two groups. The target missing rate in CBCT, adverse events and short-term efficacy of radiotherapy were analyzed in two groups. Results There was no significant difference in the volume of target area and OARs in the target area between two groups (both P>0.05). In the study group, the target missing rate and target missing volume were significantly lower compared with those in the control group (both P<0.05). There was no significant difference in the incidence of acute radiation-induced adverse events between two groups (P>0.05). The 1-, 2-year overall survival and progress-free survival did not significantly differ between two groups (all P>0.05). One patient in the study group had uterine recurrence and 2 cases in the control group. Conclusion Application of individualized cervix-uterine ITV and PTV in definitive VMAT under different bladder filling conditions can improve the accuracy of target area contouring and improve the local control rate in cervical cancer patients.
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Articles by authors
Ma Jianping
Pan Wenyan
Xia Xinshe
Ye Hongqiang
He Jianli
Bai Xuehong
Feng Yangyang
Kong Wei
Jin Xiaofeng
Zhao Ren
Key wordsBladder filling      Internal target volume      Cervical neoplasm/volume-modulated arc therapy      Treatment outcome     
Received: 03 June 2019     
Fund:Ningxia Key Research and Development Program (2016KJHM67)
Corresponding Authors: Zhao Ren, Email:zhaorendocter@126.com   
Cite this article:   
Ma Jianping,Pan Wenyan,Xia Xinshe et al. Application of cervix-uterine ITV in volumetric modulated arc therapy for cervical cancer under different bladder filling status[J]. Chinese Journal of Radiation Oncology, 2020, 29(7): 535-539.
Ma Jianping,Pan Wenyan,Xia Xinshe et al. Application of cervix-uterine ITV in volumetric modulated arc therapy for cervical cancer under different bladder filling status[J]. Chinese Journal of Radiation Oncology, 2020, 29(7): 535-539.
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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20190603-00208     OR     http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2020/V29/I7/535
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