碳离子治疗IMRT后局部区域复发鼻咽癌初步研究——上海市质子重离子医院临床经验

doi:10.3760/cma.j.issn.1004-4221.2020.03.001

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Abstract Objective To evaluate the short-term efficacy and toxicities of intensity-modulated carbon ion radiotherapy (IMCT) for patients with locoregionally recurrent nasopharyngeal carcinoma after intensity-modulated radiotherapy (IMRT). Methods A total of 112 patients with locoregionally recurrent nasopharyngeal carcinoma undergoing salvaging IMCT between May 2015 and February 2018were enrolled in the study. All patients previously received one course of definitive X-ray IMRT. Among them,10 patients (9%) were diagnosed with stage Ⅰ,26 patients (23%) with stage Ⅱ,41 patients (37%) with stage Ⅲ and 35 patients (31%) with stage Ⅳnasopharyngeal carcinoma,respectively. The median age of the cohort was 48 years (range,17-70 years) old. The median dose to the gross tumor volume (GTV) was 60 GyE (range,50-69 GyE). Results With a median follow-up time of 20 months (range,5-45 months),20 patients died and 42 patients developed local recurrence. The 2-year overall survival (OS) and local progression-free survival (LPFS) rates were 85% and 52%. Both univariate and multivariate analyses demonstrated that stage Ⅳ disease was associated with significantly worse OS. No predictors were found for LPFS. No acute toxicity of grade 3 or higher was observed during reirradiation. Severe (grade 3 or above) late toxicities included xerostomia (n=1),hearing impairment (n=2),temporal lobe injury (n=1) and mucosal necrosis (n=19).Conclusions IMCT is an efficacious and safe treatment for patients with locoregionally recurrent nasopharyngeal carcinoma with acceptable toxicity profile. Long-term follow-up is necessary to further evaluate the long-term efficacy and late toxicities.

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	Articles by authors
	Hu Jiyi
	Gao Jing
	Hu Weixu
	Yang Jing
	Guan Xiyin
	Qiu Xianxin
	Kong Lin
	Lu Jiade

Key words： Nasopharyngeal neoplasm/intensity-modulated carbon ion radiotherapy Second-course radiotherapy Treatment outcome

Received: 15 March 2019

Fund:National Key Research and Development Program of China (2017YFC0108603);Science and Technology Development Fund of Shanghai Pudong New Area (PKJ2016-Y41);Shanghai Rising-Star Program (19QB1405500);Science and Technology Development Fund of Shanghai Pudong New Area (PKJ2017-Y51)

Corresponding Authors: Kong Lin,Email:lin.kong@sphic.org.cn;Lu Jiade,Email:jiade.lu@sphic.org.cn

Cite this article:

Hu Jiyi,Gao Jing,Hu Weixu et al. Preliminary study of intensity-modulated carbon ion reirradiation for locoregionally recurrent nasopharyngeal carcinoma after definitive IMRT——Clinical experience from Shanghai Proton Heavy Ion Hospital[J]. Chinese Journal of Radiation Oncology, 2020, 29(3): 161-165.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2020.03.001 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2020/V29/I3/161

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