不同营养支持方式对食管癌放疗患者影响

doi:10.3760/cma.j.issn.1004-4221.2019.07.006

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Abstract Objective To compare the effect of nutritional support with and without tube feeding on the incidence of adverse reactions in radiotherapy for esophageal cancer. Methods A total of 120 esophageal cancer patients with high-risk factors receiving radiotherapy were selected and randomly assigned into the tube feeding (TF,n=60) and non-tube feeding groups (NTF,n=60) according to the random number method. Nutritional interventions were performed during radiotherapy in both groups. The incidence of esophagitis and myelosuppression,pulmonary infection,nutritional status and the completion of radiotherapy were observed and statistically compared between TF and NTF groups. Results In the TF group,the incidence of ≥ grade 2 esophagitis was lower than that in the NTF group. The incidence of grade 3 esophagitis significantly differed between two groups (P<0.05). The incidence of grade 1-2 myelosuppression did not differ between two groups,whereas the incidence of grade 3 myelosuppression in the TF group was significantly lower than that in the NTF group (P<0.05). In the TF group,the incidence of pulmonary infection was remarkably lower than that in the NTF group (P<0.05). The changes of BMI and prealbumin in the TF group were better than those in the NTF group (both P<0.05). One patient in the NTF group failed to complete the radiotherapy due to grade IV esophagitis,and 5 cases in the NTF group (P<0.05). In the TF group,the length of hospital stay was significantly shortened by 6.2 d on average (P<0.05). Conclusions During radiotherapy for esophageal cancer patients with high-risk factors,nutritional support with tube feeding can effectively reduce the incidence of adverse reactions,improve the completion rate of treatment,and shorten the average length of hospital stay.

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	Articles by authors
	Cheng Guowei
	Sun Li
	Zhang Tao
	Chen Ping
	He Xiangling
	Su Dan
	Xi Hengzhi
	Zang Dingqi

Key words： Esophageal neoplasms/radiotherapy Tube feeding Esophagitis

Received: 12 April 2019

Corresponding Authors: Zhang Tao, Email:zhangt10@126.com

Cite this article:

Cheng Guowei,Sun Li,Zhang Tao et al. Effect of different nutritional support methods on esophageal cancer patients receiving radiotherapy[J]. Chinese Journal of Radiation Oncology, 2019, 28(7): 505-508.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2019.07.006 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2019/V28/I7/505

[1]徐桂琼,李民英,雷风,等. 经鼻肠管肠内营养支持在食管癌放疗患者中的应用[J]. 中国基层医药,2017,24(2):228-231. DOI:10.3760/cma.j.issn.1008-6706.2017.02.018.
Xu GQ,Li MY,Lei F,et al. Application of enteral nutrition support via naso-jejunal tube in esophageal carcinoma patients treated with radiotheraphy[J]. Chin J Prim Med Pharm,2017,24(2):228-231. DOI:10.3760/cma.j.issn.1008-6706.2017.02.018.
[2]罗丽群,冯洁栈. 留置鼻胃管注食在食管癌同步放化疗中的应用及效果[J]. 现代医药卫生,2015,31(10):1455-1457. DOI:10.3969/j.issn.1009-5519.2015.10.006.
Luo LQ,Feng JZ. Appliacation and effect of indwelling nasogastric tube feeding in esophagus cancer concurrent radiochemotherapy[J]. J Mod Med Health,2015,31(10):1455-1457. DOI:10.3969/j.issn.1009-5519.2015.10.006.
[3]殷蔚伯,余子豪,徐国镇,等. 肿瘤放射治疗学[M].4版. 北京:中国协和医科大学出版社,2007.
Yin WB,Yu ZH,Xu GZ,et al. Radiation oncology[M].4ed. Beijing:China union medical university press,2007.
[4]Arends J,Bodoky G,Bozzetti F,et al. ESPEN guidelines on enteral nutrition:non-surgical oncology[J]. Clin Nutr,2006,25(2):245-259. DOI:10.1016/j.clnu.2006.01.020.
[5]吕家华,李涛,谢丛华,等. 食管癌放疗患者肠内营养专家共识[J]. 肿瘤代谢与营养电子杂志,2015,2(4):29-32. DOI:10.16689/j.cnki.cn11-9349/r.2015.04.017.
Lyu JH,Li T,Xie CH,et al. Expert consensus on enteral nutrition in patients undergoing radiotherapy for esophageal cancer[J]. Elect J Metab Nutr Cancer,2015,2(4):29-32. DOI:10.16689/j.cnki.cn11-9349/r.2015.04.017.
[6]丛明华,李淑娈,程国威,等. 营养支持小组对于食管癌同步放化疗患者作用的研究[J]. 中国肿瘤临床,2014,41(18):1158-1162. DOI:10.3969/j.issn.1000-8179.20141364.
Cong MH,Li SL,Cheng GW,et al. Roles of nutrition support team for esophageal carcinoma patients treated with concurrent chemoradiotherapy[J]. Chin J Clin Oncol,2014,41(18):1158-1162. DOI:10.3969/j.issn.1000-8179.20141364.
[7]于振涛. 食管癌术后营养支持的研究进展[J]. 中国肿瘤临床,2014,41(23):1479-1483. DOI:10.3969/j.issn.1000-8179.20141718.
Yu ZT. Research progress in the postoperative nutritional support of esophageal carcinoma[J]. Chin J Clin Oncol,2014,41(23):1479-1483. DOI:10.3969/j.issn.1000-8179.20141718.
[8]于康,周晓容,郭亚芳. 恶性肿瘤住院患者营养风险和营养不足发生率及营养支持应用状况调查[J]. 肿瘤学杂志,2011,17(6):408-411.
Yu K,Zhou XR,Guo YF. A survey of nutritional risk,undernutrition and application of nutritional support in inpatients with cancer[J]. J Chin Oncol,2011,17(6):408-411.
[9]王琳,陈梅,明智,等. 食管癌根治术后辅助放化疗不良反应与临床因素的关系[J]. 实用癌症杂志,2017,32(9):1482-1485. DOI:10.3969/j.issn.1001-5930.2017.09.026.
Wang L,Chen M,Ming Z,et al. Analysis of the relationship between adverse reactions and clinical factors in patients with esophageal cancer after radical resection[J]. Pract J Cancer,2017,32(9):1482-1485. DOI:10.3969/j.issn.1001-5930.2017.09.026.
[10]Buntzel J,Krauss T,Buntzel H,et al. Nutritional parameters for patients with head and neck cancer[J]. Anticancer Res,2012,32(5):2119-2123.
[11]吕家华,李涛,朱广迎,等. 肠内营养对食管癌同步放化疗患者营养状况、不良反应和近期疗效影响——前瞻性、多中心、随机对照临床研究(NCT02399306)[J]. 中华放射肿瘤学杂志,2018,27(1):44-48. DOI:10.3760/cma.j.issn.1004-4221.2018.01.009.
Lyu JH,Li T,Zhu GY,et al. Influence of enteral nutrition on nutritional status,treatment toxicities,and short-term outcomes in esophageal carcinoma patients treated with concurrent chemoradiotherapy:a prospective,multicenter,randomized controlled study (NCT 02399306)[J]. Chin J Radiat Oncol,2018,27(1):44-48. DOI:10.3760/cma.j.issn.1004-4221.2018.01.009.
[12]Prado CM,Baracos VE,McCargar LJ,et al. Body composition as an independent determinant of 5-fluorouracil-based chemotherapy toxicity[J]. Clin Cancer Res,2007,13(11):3264-3268. DOI:10.1158/1078-0432. CCR-06-3067.
[13]Wu J,Huang C,Xiao H,et al. Weight loss and resting energy expenditure in male patients with newly diagnosed esophageal cancer[J]. Nutrition,2013,29(11-12):1310-1314. DOI:10.1016/j.nut.2013.04.010.