ALK重排非小细胞肺癌脑转移放疗的研究进展

doi:10.3760/cma.j.issn.1004.4221.2019.06.016

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Abstract Brain metastasis is common in non-small-cell lung cancer (NSCLC) with driver gene mutations. At present, brain radiotherapy combined with tyrosine kinase inhibitor (TKI) is a hot topic. Anaplastic lymphoma kinase (ALK) gene rearrangement is one of the common driver mutations in NSCLC.However, the treatment of brain metastasis from NSCLC with ALK gene rearrangement has been rarely investigated. The prognosis of these patients,the role of brain radiotherapy and the proper combination of radiotherapy with ALK-TKI are worthy of further exploration.

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	Articles by authors
	Wang Wenhui
	Sun Xin
	Hui Zhouguang

Key words： Anaplastic lymphoma kinase gene rearrangement Lung neoplasm,brain metastasis/radiotherapy Lung neoplasm,brain metastasis/target therapy Progress

Received: 21 March 2018

Fund:National Key Research and Development Project (2017YFC1311000);Clinical Application Project of Beijing Municipal Commission of Science and Technology (Z171100001017114);Innovation Project of Medical and Health Science and Technology of the Chinese Academy of Medical Sciences (Major collaborative innovation project:2016-I2M-1-011);Beijing Marathon of Hope Special Foundation of Cancer Foundation of China (LC2016L03)

Corresponding Authors: Hui Zhouguang,Email:huizg@cicams.ac.cn

Cite this article:

Wang Wenhui,Sun Xin,Hui Zhouguang. Research progress on radiotherapy for brain metastasis from non-small-cell lung cancer with ALK rearrangement[J]. Chinese Journal of Radiation Oncology, 2019, 28(6): 467-471.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004.4221.2019.06.016 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2019/V28/I6/467

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