同期放化疗对不同年龄Ⅳ期非小细胞肺癌生存影响——两项前瞻性研究再分析

doi:10.3760/cma.j.issn.1004-4221.2019.04.004

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Abstract Objective To analyze the survival and toxicity after concurrent chemoradiotherapy in patients of different ages with stage Ⅳ non-small cell lung cancer (NSCLC). Methods Clinical data of 282 NSCLC patients in two prospective studies were retrospectively analyzed,who completed the protocol (at least 2 cycles of chemotherapy and thoracic radiation doses of ≥36 Gy).Among them,44 patients were assigned into in the young group (≤ 45 years old),161 patients in the middle-age group (46-64 years old) and 77 patients in the elderly group (≥ 65 years old).The clinical characteristics of patients among different groups were analyzed by χ² test. The overall survival (OS) was calculated by Kaplan-Meier method. Stratified analysis was performed by Log-rank test. Multi-factor prognosis analysis was conducted by Cox’s proportional hazards regression model. Results The incidence of NSCLC in the male patients in the elderly group was higher than that in the middle-age and young groups. The 1-,2-,3-and 5-year OS did not significantly differ among different groups (P=0.810).The OS did not significantly differ among patients of the same gender,pathological type,T stage,N stage,metastasis status,same chemotherapy cycle,primary tumor dose and comprehensive treatment and short-term response (all P>0.05).The incidence of adverse events did not considerably differ among different groups. Multivariate analysis demonstrated that age was not an independent factor for survival (P>0.05). Conclusion Patients of different ages with stage Ⅳ NSCLC obtain similar survival benefits and adverse events after concurrent chemoradiotherapy.

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	Articles by authors
	Fu Weixu
	Ouyang Weiwei
	Su Shengfa
	Ma Zhu
	Li Qingsong
	Geng Yichao
	Luo Daxian
	Yang Wengang
	Hu Yinxiang
	Li Huiqin
	He Zhixu
	Lu Bing

Key words： Lung neoplasm/three-dimensional radiotherapy Prognosis Adverse event

Received: 18 September 2018

Corresponding Authors: Lu Bing Email:lbgymaaaa@163.com

Cite this article:

Fu Weixu,Ouyang Weiwei,Su Shengfa et al. The influence of concurrent chemoradiotherapy on survival for patients of different ages with stage Ⅳnon-small cell lung cancer——reanalysis of two prospective studies[J]. Chinese Journal of Radiation Oncology, 2019, 28(4): 262-267.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2019.04.004 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2019/V28/I4/262

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