鼻咽癌放射抗拒相关microRNAs研究进展

doi:10.3760/cma.j.issn.1004-4221.2018.07.016

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Abstract

Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma originating from the nasopharyngeal epithelial tissues with a high incidence in Southeast Asia and South China. At present, radiotherapy has become the primary therapeutic modality to treat NPC. Resistance to radiotherapy poses a serious obstacle to successful therapy for NPC. It is of great importance to identify the biomarkers related to the NPC radioresistance and unravel the mechanism of radioresistance for the diagnosis and treatment of NPC patients. MicroRNAs induce translational repression or degradation of targeted mRNAs by binding to their 3’UTRs and regulate the expression of protein. MicroRNAs are involved in the regulation of all important cellular processes associated with response to the radiotherapy, such as DNA damage response and repair, cellular apoptosis, proliferation and angiogenesis. In recent years, the study of miRNAs associated with radioresistance of NPC has captivated widespread attention from researchers. In this review, relevant microRNAs and their potential mechanisms were summarized.

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	Articles by authors
	Li Kaiguo
	Qu Song

Key words： Nasopharyngeal neoplasms/radiotherapy Radioresistance microRNAs Biomarker

Received: 30 October 2017

Fund:

Key laboratory of High-Incidence-Tumor Prevention & Treatment (Guangxi Medical University),Ministry of Education (GKZ201607,GJZ201607,GKE2017-ZZ04);The Training Project for Excellent Middle-aged/YoungTeachers in Guangxi Higher Education Institutions (KY2016YB083)

Corresponding Authors: Qu Song,Email:daisyqs2002@163.com

Cite this article:

Li Kaiguo,Qu Song. Research progress in microRNAs associated with radioresistance of nasopharyngeal carcinoma[J]. Chinese Journal of Radiation Oncology, 2018, 27(7): 696-700.

URL:

http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2018.07.016 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2018/V27/I7/696

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