头颈部黏膜恶性黑色素瘤手术联合放疗的预后分析

doi:10.3760/cma.j.issn.1004-4221.2018.12.002

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Abstract Objective To evaluate the clinical efficacy,failure pattern and prognostic factors of the malignant mucosal melanoma of the head and neck (MMHN) in a single center. Methods The treatment pattern,clinical efficacy,failure pattern and prognostic factors of 194 M0 MMHN patients admitted to our institution from 1982 to 2017 were retrospectively analyzed. Results The 5-year overall survival (OS),local recurrence-free survival (LRFS),regional recurrence-free survival (RRFS) and distant metastasis-free survival (DMFS) were 41.4%,57.8%,76.5% and 46.5%,respectively. The failure rate was calculated as 74.6%(141/189).Among them,40%(56/141) had distant metastasis as the first pattern of treatment failure,37%(52/141) had local relapse,15%(21/141) had regional relapse,5%(7/141) had concurrent distant metastasis and local/regional relapse and 3%(5/141) had concurrent local and regional relapse. Multivariate analysis demonstrated that surgical margins (P=0.001) and adjuvant radiotherapy (P=0.000) were the independent prognostic factors for LRFS. Conclusions Surgery combined with radiotherapy can yield relatively high LRFS in the comprehensive treatment of MMHN.Distant metastasis is the major failure pattern.

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	Articles by authors
	Sun Shiran
	Yi Junlin
	Gao Li
	Huang Xiaodong
	Luo Jingwei
	Zhang Ye
	Zhang Shiping
	Wang Kai
	Qu Yuan
	Wu Runye
	Liu Qingfeng
	Chen Xuesong
	Xiao Jianping
	Xu Guozhen

Key words： Head neck neoplasmsm/radiotherapy Melanoma/radiotherapy Prognosis

Received: 13 June 2018

Fund:The National Key Projects of Research and Development of China (2017YFC0107500);The National Key Projects of Research and Development of China (2016YFC0904600)

Corresponding Authors: Yi Junlin, Email:yijunlin1969@163.com

Cite this article:

Sun Shiran,Yi Junlin,Gao Li et al. Analysis of clinical efficacy,failure pattern and prognostic factors of comprehensive treatment for malignant mucosal melanoma of head and neck[J]. Chinese Journal of Radiation Oncology, 2018, 27(12): 1041-1045.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2018.12.002 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2018/V27/I12/1041

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