中华放射肿瘤学杂志
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Chinese Journal of Radiation Oncology  2018, Vol. 27 Issue (12): 1041-1045    DOI: 10.3760/cma.j.issn.1004-4221.2018.12.002
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Analysis of clinical efficacy,failure pattern and prognostic factors of comprehensive treatment for malignant mucosal melanoma of head and neck
Sun Shiran, Yi Junlin, Gao Li, Huang Xiaodong, Luo Jingwei, Zhang Ye, Zhang Shiping, Wang Kai, Qu Yuan, Wu Runye, Liu Qingfeng, Chen Xuesong, Xiao Jianping, Xu Guozhen
Department of Radiation Oncology,National Cancer Center/National Clinical Research Center for Cancer/ Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China
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Abstract  Objective To evaluate the clinical efficacy,failure pattern and prognostic factors of the malignant mucosal melanoma of the head and neck (MMHN) in a single center. Methods The treatment pattern,clinical efficacy,failure pattern and prognostic factors of 194 M0 MMHN patients admitted to our institution from 1982 to 2017 were retrospectively analyzed. Results The 5-year overall survival (OS),local recurrence-free survival (LRFS),regional recurrence-free survival (RRFS) and distant metastasis-free survival (DMFS) were 41.4%,57.8%,76.5% and 46.5%,respectively. The failure rate was calculated as 74.6%(141/189).Among them,40%(56/141) had distant metastasis as the first pattern of treatment failure,37%(52/141) had local relapse,15%(21/141) had regional relapse,5%(7/141) had concurrent distant metastasis and local/regional relapse and 3%(5/141) had concurrent local and regional relapse. Multivariate analysis demonstrated that surgical margins (P=0.001) and adjuvant radiotherapy (P=0.000) were the independent prognostic factors for LRFS. Conclusions Surgery combined with radiotherapy can yield relatively high LRFS in the comprehensive treatment of MMHN.Distant metastasis is the major failure pattern.
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Articles by authors
Sun Shiran
Yi Junlin
Gao Li
Huang Xiaodong
Luo Jingwei
Zhang Ye
Zhang Shiping
Wang Kai
Qu Yuan
Wu Runye
Liu Qingfeng
Chen Xuesong
Xiao Jianping
Xu Guozhen
Key wordsHead neck neoplasmsm/radiotherapy      Melanoma/radiotherapy      Prognosis     
Received: 13 June 2018     
Fund:The National Key Projects of Research and Development of China (2017YFC0107500);The National Key Projects of Research and Development of China (2016YFC0904600)
Corresponding Authors: Yi Junlin, Email:yijunlin1969@163.com   
Cite this article:   
Sun Shiran,Yi Junlin,Gao Li et al. Analysis of clinical efficacy,failure pattern and prognostic factors of comprehensive treatment for malignant mucosal melanoma of head and neck[J]. Chinese Journal of Radiation Oncology, 2018, 27(12): 1041-1045.
Sun Shiran,Yi Junlin,Gao Li et al. Analysis of clinical efficacy,failure pattern and prognostic factors of comprehensive treatment for malignant mucosal melanoma of head and neck[J]. Chinese Journal of Radiation Oncology, 2018, 27(12): 1041-1045.
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