[an error occurred while processing this directive] | [an error occurred while processing this directive]
Preliminary study of pencil beam scanning proton and carbon ion therapy for chordoma and chondrosarcoma of head and neck
Guan Xiyin, Gao Jing, Hu Jiyi, Hu Weixu, Yang Jing, Yang Youqi, Xu Tingting, Hu Chaosu, Lu Jiade, Kong Lin
Department of Radiation Oncology,Shanghai Proton and Heavy Ion Center,Shanghai 201315,China (Guan XY,Gao J,Hu JY,Hu WX,Yang J,Hu CS,Lu JD,Kong L);Department of Radiation Oncology,Cancer Hospital Affiliated to Fudan University,200032 Shanghai,China (Yang YQ,Xu TT,Hu CS,Kong L)
Objective To evaluate the short-term efficacy and adverse events of pencil beam scanning proton and carbon ion therapy in the treatment of chordoma and chondrosarcoma of the head and neck. Methods Between July 2014 and July 31,2017,61 patients with chordoma and chondrosarcoma of the head and neck receiving proton and heavy ion therapy as the first course of radiotherapy were enrolled. Among them,45 patients were diagnosed with chordoma and 16 cases of chondrosarcoma,39 male and 22 female. The median age was 38 years old (range:14-70 years).The median maximum tumor diameter was 4.1 cm (range:0-8.6 cm).The clivus and the cervical spine were the primary tumor sites. Results Eight patients received proton therapy,21 patients were treated with proton combined with carbon ion therapy and 32 patients received carbon ion therapy. All patients successfully completed the planned radiotherapy. The medial follow-up time was 21 months (range:7-47 months).No grade 3-4 acute toxicity was observed. Only one patient suffered from radiation-induced temporal lobe injury. The 2-year progression-free survival (PFS) and overall survival (OS) were 91% and 100%. Conclusions Pencil beam scanning proton and heavy ion therapy yields relatively favorable short-term outcomes in the treatment of chordoma and chondrosarcoma of the head and neck. Nevertheless,the long-term clinical efficacy and safety remain to be investigated during follow-up.
Shanghai Science and Technology talents Program (15YF1411300)
Cite this article:
Guan Xiyin,Gao Jing,Hu Jiyi et al. Preliminary study of pencil beam scanning proton and carbon ion therapy for chordoma and chondrosarcoma of head and neck[J]. Chinese Journal of Radiation Oncology, 2018, 27(10): 886-889.
Guan Xiyin,Gao Jing,Hu Jiyi et al. Preliminary study of pencil beam scanning proton and carbon ion therapy for chordoma and chondrosarcoma of head and neck[J]. Chinese Journal of Radiation Oncology, 2018, 27(10): 886-889.
[1] Smoll NR,Gautschi OP,Radovanovic I,et al. Incidence and relative survival of chordomas:the standardized mortality ratio and the impact of chordomas on a population[J].Cancer 2013,119(11):2029-2037.DOI:10.1002/cncr.28032.
[2] Bloch O,Parsa AT.Skull base chondrosarcoma:evidence-based treatment paradigms. Neurosurg[J].Clin N Am,2013,24(1):89-96.DOI:10.1016/j.nec.2012.08.002.
[3] Di Maio S,Temkin N,Ramanathan D,et al. Currentcomprehensive management of cranial base chordomas:10-year meta-analysis of observational studies[J].J Neurosurg 2011,115(6):1094-1105.DOI:10.3171/2011.7.JNS11355.
[4] Hug EB.Review of skull base chordomas:prognostic factors and long-term results of proton-beam radiotherapy[J].Neurosurg Focus,2001,10(1):E11.
[5] Schulz-Ertner D,Haberer T,Jäkel O,et al. Radiotherapy for chordomas and low-grade chondrosarcomas of the skull base with carbon ions[J].Int J Radiat Oncol Biol Phys,2002,53(1):36-42.
[6] Zorlu F,Gurkaynak M,Yildiz F,et al. Conventional external radiotherapy in the management of clivus chordomas with overt residual disease[J].Neurol Sci,2000,21(2):203-207.
[7] Debus J,Schulz ED,Schad L,et al. Stereotactic fractionated radiotherapy for chordomas and chondrosarcomas of the skull base[J].Int J Radiat Oncol Biol Phys,2000,47(5):591-596.
[8] Sahgal A,Chan MW,Atenafu EG,et al. Image-guided,intensity-modulated radiation therapy (IG-IMRT) for skull base chordoma and chondrosarcoma:preliminary outcomes[J].Neuro Oncol,2015,17(6):889-894.DOI:10.1093/neuonc/nou347.
[9] Hug EB,Loredo LN,Slater JD,et al. Proton radiation therapy for chordomas and chondrosarcomas of the skull base[J].J Neurosurg,1999,91(3):432-439.
[10] Munzenrider JE,Liebsch NJ.Proton therapy for tumors of the skull base[J].Strahlenther Onkol,1999,175(Suppl 2):57-63.
[11] Schulz-Ertner D,Karger CP,Feuerhake A,et al. Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas[J].Int J Radiat Oncol Biol Phys, 2007,68(2):449-457.DOI:10.1016/j.ijrobp.2006.12.059.
[12] Mizoe JE,Hasegawa A,Takagi R,et al. Carbon ion radiotherapy for skull base chordoma[J].Skull Base,2009,19(3):219-224.DOI:10.1055/s-0028-1114295.
[13] Weber DC,Malyapa R,Albertini F,et al. Long term outcomes of patients with skull-base low-grade chondrosarcoma and chordoma patients treated with pencil beam scanning proton therapy[J].Radiother Oncol,2016,120(1):169-174.DOI:10.1016/j.radonc.2016.05.011.
2018, Vol. 27 
