局部晚期直肠癌术前VMAT同期加量剂量学研究

doi:10.3760/cma.j.issn.1004-4221.2017.11.015

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Abstract

Objective To investigate the dosimetric feasibility of volumetric modulated arc therapy (VMAT) with a simultaneous integrated boost (SIB-VMAT58.75 Gy) for preoperative chemoradiotherapy inpatients with locally advanced rectal cancer (LARC),and to provide a basis for clinical practice. MethodsNine patients with stage Ⅱ-Ⅲ rectal cancer who underwent preoperative concurrent chemoradiotherapy were involved in the study,and two plans were performed for each patient:SIB-VMAT58.75 Gy and VMAT50.00 Gy. For the SIB-VMAT58.75 Gy plan,the prescribed dose was 58.75 Gy (2.35 Gy/fraction) for the local rectal tumor and positive lymph nodes (GTV 58.75 Gy),and 50 Gy (2 Gy/fraction) for the regions at high risk of harboring microscopic disease (pelvic lymphatic drainage area)(PTV50 Gy).For the VMAT50.00 Gy plan,the prescribed dose was 50 Gy (2 Gy/fraction) for the regions at high risk of harboring microscopic disease (pelvic lymphatic drainage area) without a boost. The conformity index (CI),homogeneity index (HI),and dose for target areas and organs at risk (OAR) were assessed according to the dose-volume histogram. The paired t-test or nonparametric rank test was used to compare the differences between the two plans. Resutls Both plans met the prescription goal for PTV dose coverage. There was no significant difference in CI for the PTV between the two plans (1.0±0.0 vs. 1.0±0.0,P>0.05).The SIB-VMAT58.75 Gy plan had a worse HI than the VMAT50.00 Gy plan (0.2±0.2 vs. 0.1±0.0,P<0.05).There was no significant difference in V10-V50 of the small intestine,bladder,femoral heads,and pelvis between the two plans (P>0.05),but D2 cm³ of the small intestine was significantly higher in the SIB-VMAT58.75 Gy plan than in the VMAT50.00 Gy plan (P=0.038). Conclutions The SIB-VMAT58.75 Gy plan for LARC achieves required target volume dose coverage and OAR dose constraints,which is safe and feasible in terms of dosimetry,and its clinical efficacy and adverse effects need further evaluation.

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	Articles by authors
	Liu Qiteng
	Han Qian
	WangYunlai
	Yang Tao
	Chen Jing
	Wen Ke
	Zeng Mingyue
	Wang Jinyuan
	Cong Xiaohu
	Feng Linchun

Key words： Rectal neoplasms/volumetric modulated arc therapy Simultaneous integrated boost Dosimetry

Received: 14 November 2016

Corresponding Authors: Feng Linchun,Email:301flc@163.com

Cite this article:

Liu Qiteng,Han Qian,WangYunlai et al. A dosimetric study of volumetric modulated arc therapy with a simultaneous integrated boost for preoperative chemoradiotherapy in patients with locally advanced rectal cancer[J]. Chinese Journal of Radiation Oncology, 2017, 26(11): 1313-1317.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2017.11.015 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2017/V26/I11/1313

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