宫颈癌术后放疗行限定骨盆IMRT计划剂量学分析

doi:10.3760/cma.j.issn.1004-4221.2017.11.013

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Abstract

Objective To investigate the effects of bone marrow (BM)-sparing pelvic intensity-modulated radiotherapy (IMRT) after surgery for cervical cancer on radiation dose to the target volume,organs at risk (OAR),and hematologic toxicity. Methods Ten patients with cervical cancer who would receive postoperative radiotherapy were selected. BM-sparing pelvic IMRT and conventional IMRT were performed for the same image by the Varian planning system. The radiation dose to the pelvis,the dose distribution of the target volume,and the radiation dose to OAR were compared between the two plans. A total of 30 patients with cervical cancer who had received postoperative radiotherapy were selected to investigate the relationships of the radiation dose to the pelvis with the lengths of the pelvis in coronal axis,sagittal axis,and vertical axis and the pelvic volume. A total of 41 patients with cervical cancer who would receive postoperative radiotherapy were randomly divided into observation group and control group. The observation group was given BM-sparing IMRT,while the control group was given conventional IMRT.The incidence of grade ≥2 hematologic toxicity was compared between the two groups and the relationship between the hematologic toxicity and the radiation dose to the pelvis was investigated. Resutls Both groups showed excellent dose coverage to the clinical target volume. There was no significant difference in radiation dose to the OAR between the two groups (all P>0.05).However,the observation group had significantly lower Dmean,V10,V20,V40,and V50 of the pelvis than the control group (P=0.003-0.045).The Pearson correlation analysis showed that Dmean,V20,V30,V40,and V50 of the pelvis were negatively correlated with the length of the pelvis in coronal axis (P=0.008-0.038).The observation group had a significantly lower incidence of hematologic toxicity than the control group (P=0.019).The logistic regression analysis showed that the development of hematologic toxicity was significantly associated with V20 of the pelvis (OR=1.191,P=0.042). Conclutions BM-sparing IMRT after surgery for cervical cancer can reduce the radiation dose to the pelvis and the incidence of blood toxicity. The radiation dose to the pelvis is negatively correlated with the length of the pelvis in coronal axis. The development of hematologic toxicity is associated with V20 of the pelvis.

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	Articles by authors
	Zhang Daoming
	Guo Hui
	Zhang Qi
	Liu Linlin

Key words： Uterine cervical neoplasms/intensity-modulated radiotherapy Dosimetry

Received: 09 June 2017

Corresponding Authors: Liu Linlin,Email:2660424632@qq.com

Cite this article:

Zhang Daoming,Guo Hui,Zhang Qi et al. Dosimetric analysis of bone marrow-sparing pelvic intensity-modulated radiotherapy after surgery for cervical cancer[J]. Chinese Journal of Radiation Oncology, 2017, 26(11): 1303-1307.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2017.11.013 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2017/V26/I11/1303

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