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Advances in radiotherapy for small cell lung cancer in the East and West
Zhao Lujun,Wang Ping
Department of Radiation Oncology,Tianjin Medical University Cancer Institute and Hospital,Key Laboratory of Cancer Prevention and Therapy,National Clinical Research Center for Cancer,Tianjin 300060,China
Abstract Small cell lung cancer (SCLC) is one common type of lung cancer in China. No remarkable progress has been made in systemic therapy for SCLC since the 90’s. However, there are some advances in radiotherapy (RT) for SCLC, which make it possible to improve treatment outcomes of SCLC. Those advances are mainly made in thoracic RT and prophylactic cranial irradiation for extensive-stage SCLC, radiation dose and technology of thoracic RT for limited-stage SCLC, and significance of prophylactic cranial irradiation for early-stage SCLC. The paper reviews the research advances in the East and West to provide some help and references for readers.
Zhao Lujun,Wang Ping. Advances in radiotherapy for small cell lung cancer in the East and West[J]. Chinese Journal of Radiation Oncology, 2017, 26(1): 107-110.
Zhao Lujun,Wang Ping. Advances in radiotherapy for small cell lung cancer in the East and West[J]. Chinese Journal of Radiation Oncology, 2017, 26(1): 107-110.
[1] Riaz SP,Luchtenborg M,Coupland VH,et al. Trends in incidence of small cell lung cancer and all lung cancer[J].Lung Cancer,2012,75(3):280-284.DOI:10.1016/j.lungcan.2011.08.004. [2] Behera M,Ragin C,Kim S,et al. Trends,predictors,and impact of systemic chemotherapy in small cell lung cancer patients between 1985 and 2005[J].Cancer,2016,122(1):50-60.doi:10.1002/cncr.29674. [3] 陈涵一,杨琛,闫蓓,等.浦东新区不同组织学类型肺癌发病及生存情况[J].中国肺癌杂志,2014,17(3):203-208.DOI:10.3779/j.issn.1009-3419.2014.03.04 Chen H,Yang C,Yan B,et al. Occurrence and Survival Condition of Lung Cancer with Different Histologies Among Residents in Pudong New Area[J].Chin Lung J,2014,17(3):203-208.DOI:10.3779/j.issn.1009-3419.2014.03.04 [4] 姚晓军,张洪伟,强蒲,等.2000年与2010年四川大学华西医院收治肺癌患者的临床流行病学特征及病理类型分布特点[J].四川大学学报(医学版),2014,45(2):309-315. Yao XJ,Zhang HW,Pu Q,et al. Clinical epidemiology and histological characteristics of patients with lung cancer in West China Hospital of Sichuan University.[J].Sichuan Univ (med ed),2014,45(2):309-315. [5] Janne PA,Freidlin B,Saxman S,et al. Twenty-five years of clinical research for patients with limited-stage small cell lung carcinoma in North America[J].Cancer,2002,95(7):1528-1538.DOI:10.1002/cncr.10841 [6] Nickolich M,Babakoohi S,Fu P,et al. Clinical trial design in small cell lung cancer:surrogate end points and statistical evolution[J].Clin Lung Cancer,2014,15(3):207-212.DOI:10.1016/j.cllc.2013.12.001. [7] Jeremic B,Shibamoto Y,Nikolic N,et al. Role of radiation therapy in the combined-modality treatment of patients with extensive disease small-cell lung cancer:a randomized study[J].J Clin Oncol,1999,17(7):2092-2099.DOI:10.1200/jco.1999.17.7.2092 [8] Zhu H,Zhou Z,Wang Y,et al. Thoracic radiation therapy improves the overall survival of patients with extensive-stage small cell lung cancer with distant metastasis[J].Cancer,2011,117(23):5423-5431.DOI:10.1002/cncr.26206 [9] Slotman BJ,Faivre-Finn C,Tinteren Hv,et al. International multicenter randomized study on thoracic radiation therapy (RT) in extensive stage small cell lung cancer (ES-SCLC):patterns of disease recurrence[J].Int J Radiat Oncol Bio Phys,2014,90(Suppl 1):S3-S4. [10] Slotman BJ,Faivre-Finn C,Tinteren Hv,et al. Randomized trial on thoracic radiotherapy (TRT) in extensive-stage small cell lung cancer[J].J Clin Oncol,2014,32(Suppl);abstr 7502. [11] 徐利明,赵路军,陈秀丽,等.广泛期SCLC不同放疗分割方式疗效比较[J].中华放射肿瘤学杂志,2015,24(5):488-492.DOI:10.3760/cma.j.issn.1004-4221.2015.05.003. Xu L,Zhao L,Chen X,et al. Comparison of efficacy of different fractionation schedules in radiotherapy for extensive-stage small cell lung cancer[J].Chin J Radiat Oncol,2015,24(5):488-492.DOI:10.3760/cma.j.issn.1004-4221.2015.05.003. [12] Slotman B,Faivre-Finn C,Kramer G,et al. Prophylactic cranial irradiation in extensive small-cell lung cancer[J].N Engl J Med,2007,357(7):664-672.DOI:10.1056/NEJMoa071780. [13] Seto T,Takahashi T,Yamanaka T,et al. Prophylactic cranial irradiation (PCI) has a detrimental effect on the overall survival (OS) of patients (pts) with extensive disease small cell lung cancer (ED-SCLC):results of a Japanese randomized phase Ⅲ trial[J].J Clin Oncol,2014,32(Suppl);abstr 7503. [14] Auperin A,Arriagada R,Pignon JP,et al. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group[J].N Engl J Med,1999,341(7):476-484.DOI:10.1056/NEJM199908123410703. [15] Meert AP,Paesmans M,Berghmans T,et al. Prophylactic cranial irradiation in small cell lung cancer:a systematic review of the literature with meta-analysis[J/OL].BMC Cancer,2001,1:5. [16] Wu AJ,Gillis A,Foster A,et al. Should all limited-stage small cell lung cancer be treated alike? Impact of AJCC stage on brain metastasis,survival,and patterns of failure[J].Int J Radiat Oncol Bio Phys,2014,90(Suppl 1):S61. [17] Gong L,Wang Q,Zhao L,et al. Factors affecting the risk of brain metastasis in small cell lung cancer with surgery:is prophylactic cranial irradiation necessary for stage Ⅰ-Ⅲ disease?[J].Int J Radiat Oncol Biol Phys,2013,85(1):196-200.DOI:10.1016/j.ijrobp.2012.03.038. [18] De Ruysscher D,Bremer RH,Koppe F,et al. Omission of elective node irradiation on basis of CT-scans in patients with limited disease small cell lung cancer:a phase Ⅱ trial[J].Radiother Oncol,2006,80(3):307-312.DOI:10.1016/j.radonc.2006.07.029. [19] Baas P,Belderbos JS,Senan S,et al. Concurrent chemotherapy (carboplatin,paclitaxel,etoposide) and involved-field radiotherapy in limited stage small cell lung cancer:a Dutch multicenter phase Ⅱ study[J].Br J Cancer,2006,94(5):625-630.DOI:10.1038/sj.bjc.6602979. [20] van Loon J,De Ruysscher D,Wanders R,et al. Selective nodal irradiation on basis of (18) FDG-PET scans in limited-disease small-cell lung cancer:a prospective study[J].Int J Radiat Oncol Biol Phys,2010,77(2):329-336.DOI:10.1016/j.ijrobp.2009.04.075. [21] Hu X,Bao Y,Zhang L,et al. Omitting elective nodal irradiation and irradiating postinduction versus preinduction chemotherapy tumor extent for limited-stage small cell lung cancer:interim analysis of a prospective randomized noninferiority trial[J].Cancer,2012,118(1):278-287.DOI:10.1002/cncr.26119. [22] 徐利明,曹玲,郝建磊,等.无锁骨上淋巴结转移的局限期小细胞肺癌颈部预防照射临床分析[J].中国肿瘤临床,2010,37(10):594-596.DOI:10.3969/j.issn.1000-8179.2010.10.015. Xu L,Cao L,Hao J,et al. Clinical Analysis of Prophylactic Neck Irradiation in Limited Stage Small Cell Lung Cancer Patients without Neck Metastasis[J].Chin Tumor Clin,2010,37(10):594-596.DOI:10.3969/j.issn.1000-8179.2010.10.015. [23] 冯振兴,赵路军,关勇,等.局限期小细胞肺癌锁骨上区淋巴结转移规律及靶区勾画[J].中华医学杂志,2013,93(19):1476-1478.DOI;10.3760/cma.j.issn.0376-2491.2013.19.010. Feng ZX,Zhao LJ,Guan Y,et al. Metastatic characteristics of lymph node in supraclavicular zone and radiotherapy target volume for limited-stage small cell lung cancer[J].Chin J Med,2013,93(19):1476-1478.DOI;10.3760/cma.j.issn.0376-2491.2013.19.010 [24] 刘志艳,姬凯,刘维帅,等.应用根治性IMRT结合降低预防照射区剂量治疗Ⅲ期SCLC研究[J].中华放射肿瘤学杂志,2014,23(2):123-126.DOI;10.3760/cma.j.issn.1004-4221.2014.02.011. Liu Z,Ji K,Liu W,et al. Clinical efficacy of radical intensity-modulated radiotherapy combined with reduction in dose of prophylactic irradiation in treatment of stage Ⅲ small cell lung cancer[J].Chin J Radiat Oncol,2014,23(2):123-126.DOI;10.3760/cma.j.issn.1004-4221.2014.02.011. [25] Liu Z,Zhao L,Yuan Z,et al. The impact of does reduction elective nodal irradiation in limited-stage small-cell lung cancer[J].Int J Radiat Oncol Bio Phys,2015,93:3(Suppl):E446. [26] Sun JM,Ahn YC,Choi EK,et al. Phase Ⅲ trial of concurrent thoracic radiotherapy with either first-or third-cycle chemotherapy for limited-disease small-cell lung cancer[J].Ann Oncol,2013,24(8):2088-2092.DOI:10.1093/annonc/mdt140. [27] Wang P,Liu W,Zhao L,et al. Does the response to induction chemotherapy impact the timing of thoracic radiotherapy for limited-stage small-cell lung cancer?[J] Thorac Cancer,2015,6(5):605-612.DOI:10.1111/1759-7714.12229.
2017, Vol. 26 
