NSCLC-SBRT中4D-CBCT图像配准方式研究

doi:10.3760/cma.j.issn.1004-4221.2016.01.018

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Abstract Objective To investigate the artificial and gray T+R 4D-CBCT image registration for non-small cell lung cancer (NSCLC) with SBRT. Methods 2D SBRT 10 patients with NSCLC,their 4D-CBCT scan images and reference CT images were registered by the methods of artificial and gray T+R registration. The maximum mutual information (MI),Haunsdorff distance and average symmetry distance (ASD) were calculated and were analyzed by paired-t test. Results In 1-3 fraction SBRT,the maximum MI for Gray T+R registration was averaged improved 8.8%(P=0.003,0.000,0.008),Haunsdorff distance and ASD were averaged reduced 21.1%(P=0.000,0.000,0.000) and 13.4%(P=0.000,0.002,0.018) respectively,and they all had the statistical significance compared with artificial registration in the early period of treatment;in 6-8 fraction SBRT,compared with gray T+R registration the maximum MI for artificial registration was averaged improved 19.3%(P=0.014,0.000,0.000),Haunsdorff distance and ASD were averaged reduced 17.6%(P=0.000,0.000,0.000) and 19.6%(P=0.001,0.000,0.000) respectively,and they also had the statistical significance. Conclusions Gray T+R image registration was reasonable in early period of treatment and artificial image registration was available in later period of treatment.

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	Articles by authors
	Wang Jiahao
	Li Xiadong
	Xia Bing
	Deng Qinghua
	Xu Lixia
	Ren Yao
	Lai Jianjun
	Tang Rongjun

Key words： Tomography,X-ray computed,cone beam,four-dimensional Image registration,artificial Image registration,gray T+R Maximum mutual information Haunsdorff distance Average symmetry distance

Received: 07 May 2014

Corresponding Authors: Li Xiadong,Email:hehe8812@126.com

Cite this article:

Wang Jiahao,Li Xiadong,Xia Bing et al. The application research about registration methods of 4D-CBCT in non-small cell lung cancer with SBRT[J]. Chinese Journal of Radiation Oncology, 2016, 25(1): 71-75.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2016.01.018 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2016/V25/I1/71

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