Department of Radiation Oncology, Tianjin Medical University Cancer Institute& Hospital, Key Laboratory of Cancer Prevention and Therapy,National Clinical Research Center for Cancer,Tianjin 300060,China
Abstract Objective To evaluated the role of postoperative radiotherapy (PR) after surgery in patients with uterine sarcoma,and analyzed the prognostic factors. Methods A total of 182 patients with uterine sarcoma were included between June 1994 and October 2014. Radiotherapy dose were 30-50 Gy/10-25 fractions/5 fractions/week. The LRFFS and OS were calculated with Kaplan-Meier method, and difference was analyzed with log-rank method. Cox regression analyses were used to determine prognosticators. Results There were 114 patients which survived more than 5-years in this whole group, including PR 24 cases and no PR 90 cases. The 5-year LRRFS and OS were 62.1% and 56.2%,respectively. The 5-year LRRFS were 78.0% and 55.3% on PR and no PR (P=0.013);with OS 64.1% and 51.7% on PR and no PR (P=0.070).A multivariate analysis showed that pathological types, histological grade and clinical stage were associated with LRRFS and OS (P=0.032,0.008, 0.000 and 0.046,0.000,0.000). PR was significant influencing factor for OS (P=0.013). Conclusions Uterine sarcoma patients treated with PR after surgery had an improved LRRFS compared to those treated with surgery,especially those with leiomyosarcoma. The role of PR personalized radiation for uterine sarcoma still needs to be further discussed.
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2016, Vol. 25 
