CT引导下子宫内膜癌3D腔内近距离治疗计划的剂量学分析

doi:10.3760/cma.j.issn.1004-4221.2015.05.024

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Abstract Objective To study the dosimetric peculiarity of 3D intracavitary brachytherapy in the application of endometrial carcinoma comparing with traditional 2D plans. Method 39 3D brachytherapy treatment plans of 11 patients with endometrial carcinoma were retrospectively analyzed with re-planning 2D treatment plan, the dose volume histogram (DVH) parameters such as the target dose volume parameters V₁₅₀ and D₉₀, the 2-cc doses to organs such as bladder,small intestine,rectum and sigmoid and the total reference air kerma TRAK were analyzed. The differences between the two groups are compared by paired samples T test. Results For target with V<60 cm³,there is no statistically significant difference between 2D and 3D plans,the D₉₀ is (551.17±90.33) cGy and (574.15±117.18) cGy,respectively (P=0.390). As the increase of target volume,the D₉₀ came to be significantly different (P=0.001), high dose region V₁₅₀ for 3D and 2D plans is (51.05±21.61) cm³ and (53.41±11.71) cm³, respectively (P=0.482). With the target volume larger than 60 cm³,compare to 2D plans, the 3D plan can increase the target coverage as well as OAR dose except for small intestine (P=0.128). In addition, with different plan mode,the BMI did not affect the crisis organ dose such as rectum,small intestine, bladder and sigmoid,the P value is 0.239,0.198,0.744 and 0.834,respectively. Conclusions For endometrial carcinoma,compared with traditional two-dimensional plans,the 3D brachytherapy treatment plans can significantly improve the target coverage and avoiding overdose of organs, clinical curative effect and side effect still needs further observation.

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	Articles by authors
	Yu Lang
	Zhang Yu
	Sun Xiansong
	Wang Xinhai
	Yan Junfang
	Yang Bo
	Qiu Jie

Key words： Endometrial carcinoma/three-dimensional intracavitary brachytherapy Dose volume histogram Body mass index

Cite this article:

Yu Lang,Zhang Yu,Sun Xiansong et al. Dosimetric analysis of computed tomography guided three-dimensional intracavitray brachytherapy in endometrial carcinoma[J]. Chinese Journal of Radiation Oncology, 2015, 24(5): 569-572.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2015.05.024 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2015/V24/I5/569

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