T1-2N1M0期鼻咽癌IMRT同期化疗疗效分析

doi:10.3760/cma.j.issn.1004-4221.2015.05.013

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Abstract Objective To retrospectively analyze the efficacy and toxicity of intensity-modulated radiotherapy (IMRT) alone and IMRT with concurrent chemotherapy (CRT) in the treatment of early-stage nasopharyngeal carcinoma (NPC) using pairwise group comparison. Methods A total of 98 patients with stage T_1-2N₁M₀ NPC were treated with IMRT alone or CRT from 2009 to 2010, and 39 pairs out of them were selected for comparison of efficacy and toxicity. The survival rates were calculated using the Kaplan-Meier method and analyzed using the log-rank test. Results The 3-year follow-up rate was 95%. There were no significant differences in the 3-year overall survival (OS), progression-free survival (PFS), local recurrence-free survival (LRFS), and distant metastasis-free survival (DMFS) rates between the IMRT alone group and the CRT group (97% vs. 95%, P=0.411;97% vs. 92%, P=0.301;97% vs. 97%, P=0.606;100% vs. 92%, P=0.082). The incidence rates of leucopenia, anemia, and thrombocytopenia were significantly higher in the CRT group than in the IMRT alone group (P=0.000;P=0.000;P=0.000). There were no significant differences in the incidence rates of grade 3 oral mucositis and hearing loss between the IMRT alone group and the CRT group (26% vs. 23%, P=0.093;41% vs. 62%, P=0.100). Conclusions CRT fails to increase the OS, PFS, and LRFS rates and reduce the DMFS rate in patients with stage T_1-2N₁ NPC. Moreover, CRT results in higher incidence rates of hematotoxicity, grade 3 mucositis, and hearing loss than IMRT alone.

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	Articles by authors
	Jiang Shaona^*
	Li Fei
	Xie Li
	Dou Shengjin
	Zhu Guopei
	Hu Chaosu

Key words： Nasopharyngeal neoplasms/intensity-modulated radiotherapy Nasopharyngeal neoplasms/concurrent chemoradiotherapy Prognosis

Cite this article:

Jiang Shaona^*,Li Fei,Xie Li et al. An analysis of efficacy of intensity-modulated radiotherapy with concurrent chemotherapy for stage T_1-2N₁ nasopharyngeal carcinoma[J]. Chinese Journal of Radiation Oncology, 2015, 24(5): 529-531.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2015.05.013 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2015/V24/I5/529

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