Abstract Objective To investigate the patterns of intrathoracic lymph node metastasis in non-small cell lung cancer (NSCLC) and to provide a theoretical basis for the delineation of radiotherapy target volume. Methods A retrospective analysis was performed on the clinical data of 314 NSCLC patients after operation. Our focus was to investigate the distribution characteristics and metastatic extent of intrathoracic lymph nodes and their relationship with tumor size, pathological type, and primary site. Comparisons between groups were made by one-way analysis of variance. Results The frequencies of metastases to lymph nodes at stations 4, 5, 7, 10, and 11 were all above 12%, while those at stations 1, 2, 3, 6, 8, and 9 were all below 12%. The lymph node metastasis rate was similar on the primary tumor site (P=0.102).The patients with T3 and T4 NSCLC had a significantly higher frequency of N2 lymph node metastasis than those with T1 and T2 NSCLC (17.0% vs. 11.6%,P=0.002);the patients with adenocarcinoma had a significantly higher frequency of N2 lymph node metastasis than those with squamous cell carcinoma (34.5% vs. 23.2%,P=0.008). Conclusions For patients with T3 and T4 NSCLC of adenocarcinoma subtype, we should highlight the lymph nodes at stations 4, 5, 7, 10, and 11 when delineating the radiotherapy target volume after operation.
Corresponding Authors:
Shi jingbin,Email:1963 sjb@163.com
Cite this article:
Zhang Haichen,Shi jingbin,Zha Jiandong. Clinical significance of patterns of intrathoracic lymph node metastasis in non-small cell lung cancer:an analysis of 314 patients[J]. Chinese Journal of Radiation Oncology, 2014, 23(4): 294-296.
Zhang Haichen,Shi jingbin,Zha Jiandong. Clinical significance of patterns of intrathoracic lymph node metastasis in non-small cell lung cancer:an analysis of 314 patients[J]. Chinese Journal of Radiation Oncology, 2014, 23(4): 294-296.
[1] Frank C, Detterbeck MD.The new lung cancer staging system[J].Chest,2009,136:260-271. [2] Yoshino L, Yokoyama H, Yano T, et al. Skip metastasis to the mediastinal lymph nodes in non-small cell lung cancer[J]. Ann Thorac Surg,1996,62:1021-1025. [3] 孙即昆,赵崇伟,翁品光.肺外科学[M].北京:人民卫生出版社,1987:24-25. [4] 田界勇,魏大中,马冬春.非小细胞肺癌淋巴结转移规律分析[J].中国癌症杂志,2012,22:285-288. [5] 陈福楠.861 例非小细胞肺癌淋巴结转移规律及临床意义[D].福州:福建医科大学,2012. [6] 许罡,汪栋,张传生,等.非小细胞肺癌淋巴结转移规律的研究[J].临床肿瘤学杂志,2009,14:927-929. [7] 岳金波,王真真,于金明.ⅢA期非小细胞肺癌术后治疗研究现状[J].中华肿瘤防治杂志,2013,20:1614-1618. [8] 刘翼,阿迪力,陈艳荣,等.ⅢA(N2)期非小细胞肺癌术后放疗疗效分析[J].中国癌症杂志,2013,23:452-456. [9] Yoshihisa S, Hisashi S, Masatoshi K, et al. Retrospective analysis of nodal spread patterns according to tumor location in pathological N2 non-small cell lung cancer[J]. World J Surg,2012,36:2865-2871. [10] 杨锫,师颖瑞,杨敬瑞.ⅢA期N2非小细胞肺癌术后放疗疗效及预后因素分析[J].临床肺科杂志,2013,18:1100-1102. [11] Masaoki I, Yoshinori Y, Yasuhiro T, et al.Classifications of N2 non-small-cell lung cancer based on the number and rate of metastatic mediastinal lymph nodes[J].Clin Lung Cancer,2013,14:651-657.
2014, Vol. 23 
