Abstract Objective To investigate the accuracy of CTVision image-guided stereotactic body radiation therapy (SBRT) for non-small cell lung cancer (NSCLC). Methods 10 lung SBRT patients were imaged with CTVision before and after irradiation for acquiring and analyzing the three-dimensional set-up error data sets in our department from October 2010 to May 2012. Gross tumor volumes (GTVs) were contoured on pre-and post-SBRT CT sets and combined for generating internal gross tumor volumes (IGTVs). Planning target volume (PTV) margin was calculated, and IGTVs and PTVs were compared for off-line verification of accuracy of SBRT. A paired t-test statistical analysis was conducted with the datasets using SPSS 17.0. Results 80 CT image sets were totally obtained. Setup errors was significant difference before and after radiotherapy in the left-right, superior-inferior and anterior-posterior directions, that were (－0.10±1.30) mm and (－0.15±1.31) mm (P=0.720),(0.18±1.32) mm and (0.18±1.43) mm (P=1.000) and (－0.08±1.19) mm and (－0.13±1.18) mm (P=0.750), respectively. IGTVs of ten patients were smaller than corresponding PTVs (13.53 cm3 and 37.84 cm3, P=0.000). ConclusionAccuracy and safety of SBRT could be verified by imaging with CTVision before and after delivery for non-small cell lung cancer.
Corresponding Authors:
GE Hong, Email:gehong66@gmail.com
Cite this article:
ZHENG Xiao-li,YE Ke,MAO Rong-hu et al. Evaluation of the accuracy of CTVision image-guided stereotactic body radiation therapy for non-small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2013, 22(6): 485-488.
ZHENG Xiao-li,YE Ke,MAO Rong-hu et al. Evaluation of the accuracy of CTVision image-guided stereotactic body radiation therapy for non-small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2013, 22(6): 485-488.
[1] Potters L, Steinberg M, Rose C, et al. American Society Therapeutic Radiology and Oncology and American College of Radiology practice guide lines for the performance of Stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys,2004,60:1026-1032. [2] Baumann P, Nyman J, Hoyer M, et al. Outcome in a prospective phase Ⅱ trial ofmedically inoperable stage Ⅰ non-small cell lung cancer patients treated with stereotactic body radiotherapy. J Clin Oncol,2009,27:3290-3296. [3] Fakiris AJ, McGarry RC, Yiannoutsos CT, et al. Stereotactic body radiation therapy for early-stage non-small cell lung carcinoma:four year results of a prospective phase Ⅱ study. Int J Radiat Oncol Biol Phys,2009,75:677-682. [4] Takeda A, Sanuki N, Kunieda E, et al. Stereotactic body radiotherapy for primary lung cancer at a dose of 50 Gy total in five fractions to the periphery of the planning target volume calculated using a superposition algorithm. Int J Radiat Oncol Biol Phys,2009,73:442-448. [5] 0nishi H, Shirato H, Nagata Y, et al. Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage Ⅰ non-small cell lung cancer:updated results of 257 patients in a Japanese multi-institutional study. J Thorac Oncol,2007, 2(7 Suppl 3):S94-100. [6] Ge H, Cai J, Kelsey CR, et al. Quantification and minimization of uncertainties of internal target volume for stereotactic body radiation therapy of lung cancer. Int J Radiat Oncol Biol Phys,2013,In press. [7] Perez CA, Brady LW.放射肿瘤学原理和实践.朱广迎,李晔雄,夏廷毅,等主译.天津:天津科技翻译出版公司,2012:315. [8] Liu HH, Balter P, Tutt T, et al. Assessing respiration-induced tumor motion and internal target volume using 4D-CT for radiation therapy of lung cancer. Int J Radiat Oncol Biol Phys,2007,68:531-540. [9] Astreinidou E, Bel A, Raajmakers CP, et al. Adequat margins for random setup uncertatinties in head-and-neck IMRT. Int J Radiat Oncol Biol Phys,2005,61:938-944. [10] Belderbos JS, De Jaeger K, Heemsbergen WD, et al. First results of a phase Ⅰ/Ⅱ dose escalation trial in non-small cell lung cancer using three dimensional conformal radiotherapy. Radiother Oncol,2003,66:119-126. [11] RADIATION THERAPY ONCOLOGY GROUP RTOG 0915 A RANDOMIZED PHASE Ⅱ[2012-11-16].http://pdf.asaha.com/ RADIATION-THERAPY-ONCOLOGY-GROUP-RTOG-0915-A-RANDOMIZED-PHASE-Ⅱ-download—w145.pdf. [12] Siedschlag C, Boersma L, van Loon J, et al. The impact of microscopic disease on the tumor control probability in non-small cell lung cancer. Radiother Oncol,2011,100:344-350. [13] Underberg RW, Lagerwaard FJ, Cuijpers JP,et al. Four-dimensional CT scans for treatment planning in stereotactic radiotherapy for stage Ⅰ lung cancer. Int J Radiat Oncol Biol Phys,2004,60:1283-1290.
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