胃癌术后辅助放化疗与辅助化疗比较的荟萃分析

doi:10.3760/cma.j.issn.1004-4221.2013.06.003

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Abstract Objective To compare postoperative adjuvant chemoradiotherapy with adjuvant chemotherapy in patients with gastric cancer by a meta-analysis. Methods PubMed, EMbase, Cochrane Library, Wanfang, CNKI, VIP, and CBM databases were searched to identify the controlled clinical trials of postoperative adjuvant chemoradiotherapy versus adjuvant chemotherapy for gastric cancer. The obtained data were analyzed using RevMan 5.2.5 and Stata 12.0. The difference between two groups was estimated by calculating the odds ratio (OR) with 95% confidence interval (CI). Results A total of 12 controlled clinical trials involving 1674 gastric cancer patients, which were selected according to inclusion and exclusion criteria, were included in this meta-analysis. The meta-analysis showed that the 3-and 5-year survival rates were significantly higher in the adjuvant chemoradiotherapy group than in the adjuvant chemotherapy group (OR=2.96, 95%CI=1.75—5.03, P=0.000;OR=1.45, 95%CI=1.06—1.99, P=0.020);the local recurrence rate was significantly lower in the adjuvant chemoradiotherapy group than in the adjuvant chemotherapy group (OR=0.50, 95%CI=0.34—0.72, P=0.000);there was no significant difference in distant metastasis rate between the two groups (OR=0.79, 95%CI=0.58—1.07, P=0.130). Conclusions The meta-analysis of existing study results shows that compared with adjuvant chemotherapy alone, adjuvant chemoradiotherapy is a relatively safe and effective postoperative treatment for gastric cancer.

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	GUO Qi
	HUANG Wei-xian
	CUI Xi-xi
	ZHANG Li-yuan
	TIAN Ye.

Key words： Stomach neoplasms/combined modality therapy Postoperative radiochemotherapy Postoperative chemotherapy Meta-analysis

Received: 22 May 2013

Corresponding Authors: ZHANG Li-yuan, Email:zhangliyuan126@126.com

Cite this article:

GUO Qi,HUANG Wei-xian,CUI Xi-xi et al. A meta-analysis of controlled clinical trials comparing postoperative adjuvant chemoradiotherapy with adjuvant chemotherapy in patients with gastric cancer[J]. Chinese Journal of Radiation Oncology, 2013, 22(6): 433-436.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2013.06.003 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2013/V22/I6/433

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