基于数据库的宫颈癌自动调强计划设计可行性研究

doi:10.3760/cma.j.issn.1004-4221.2020.02.014

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Abstract Objective To develop and evaluate an automatic intensity-modulated radiation therapy (IMRT) program for cervical cancer based on a database of overlap volume histogram (OVH) and high-quality cervical IMRT plans for previously-treated patients. Methods A database consisting of high-quality IMRT plans and OVHs from 200 cervical cancer patients was established. OVHs of another 26 cervical cancer patients were converted into gray level images to calculate the image similarity compared with those from the database. The planning optimization function of the patients from the database with the highest image similarity was selected and inherent Pinnacle³ scripts were utilized to automatically generate IMRT plan. Finally,the dosimetric parameters,plan quality and design time were statistically compared between the automatic and manual plans. Results The target coverage,conformity index and homogeneity index did not significantly differ between two plans (all P>0.05). The V40,V45 and mean dose for the rectum in the automatic plans were significantly decreased by 6.1%,1.3% and 50.7 cGy than those in the manual plans (all P<0.05). Compared with the manual plans,the mean dose for the intestine and femur in the automatic plans were significantly reduced by 31.7 cGy and 188.9 cGy (both P<0.05),whereas the mean dose for the ilium was slightly decreased by 92.3 cGy in the automatic plans (P>0.05). The plan design time was shortened by 71% in the automatic plans. Conclusions The automatic IMRT plans based on a database of OVH and high-quality IMRT plans can not only significantly shorten the plan design time,but also reduce the irradiated dose of normal tissues without compromising the target coverage and conformity index.

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	Articles by authors
	Chen Jihong
	Bai Penggang
	Chen Wenjuan
	Chen Kaiqiang
	Li Qixin
	Zhang Xiuchun
	Dai Yitao
	Weng Xing
	Qian Jiewei

Key words： Cervical neoplasm/intensity-modulated radiation therapy Overlap volume histogram Automatic plan

Received: 27 March 2019

Fund:Fujian Provincial Health Technology Project (2017-ZQN-15, 2018-ZQN-19,2017-CX-8);Science and Technology Program of Fujian Province (2018Y2003)

Corresponding Authors: Bai Penggang,Email:littlewind@sina.cn

Cite this article:

Chen Jihong,Bai Penggang,Chen Wenjuan et al. Feasibility of automatic IMRT planning for cervical cancer based on a database of previously-treated patients[J]. Chinese Journal of Radiation Oncology, 2020, 29(2): 141-145.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2020.02.014 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2020/V29/I2/141

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