Abstract Radiotherapy is an important part of the postoperative adjuvant therapy of cervical cancer. Along with the persistent development of radiotherapy techniques,the application of brachytherapy has been more and more used as a boost to external beam radiotherapy. In this artical,the indications of postoperative radiotherapy and the application of brachytherapy were reviewed.
Fund:National Natural Science Foundation of China (31600679);National Natural Science Foundation of China (81703034);Project of Science and Technology Department of Jilin Province (20090458);Project of Science and Technology Department of Jilin Province (20190303151SF);Project of Health and Family Planning Commission of Jilin Province (2014ZC054);Bethune Special Research of Science and Technology Department of Jilin Province (20160101079JC);Horizontal Project of Jilin University (2015373)
Qu Hongda,Shi Dan,Zhang Ning et al. Research progress inpostoperative brachytherapy for cervical cancer[J]. Chinese Journal of Radiation Oncology, 2019, 28(9): 717-720.
Qu Hongda,Shi Dan,Zhang Ning et al. Research progress inpostoperative brachytherapy for cervical cancer[J]. Chinese Journal of Radiation Oncology, 2019, 28(9): 717-720.
[1] Landoni F,Maneo A,Colombo A,et al. Randomised study of radical surgery versus radiotherapy for stage Ⅰ b-Ⅱ a cervical cancer[J]. Lancet,1997,350(9077):535-540. DOI:10.1016/S0140-6736(97)02250-2. [2] Samlal RK,Van Der Velden J. Early cervical carcinoma:how to manage high-risk patients after radical hysterectomy[J]. Eur J Obstet Gynecol Reproduct Biol,1999,85(2):137-139. [3] Cervical cancer[DB/OL][2018-12-09].https://www.nccn.org/professionals/physician_gls/pdf/cervical.pdf. [4] Marth C,Landoni F,Mahner S,et al. Cervical cancer:ESMO clinical practice guidelines for diagnosis,treatment and follow-up[J]. Ann Oncol,2017,28(Suppl_4):iv72-iv83. DOI:10.1093/annonc/mdx220. [5] Marth C,Landoni F,Mahner S,et al. Cervical cancer:ESMO clinical practice guidelines for diagnosis,treatment and follow-up[J]. Ann Oncol,2018,29(Suppl 4):iv262-iv262. DOI:10.1093/annonc/mdy160. [6] Sedlis A,Bundy BN,Rotman MZ,et al. A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage is carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy:a gynecologic oncology group study[J]. Gynecol Oncol,1999,73(2):177-183. DOI:10.1006/gyno.1999.5387. [7] Rotman M,Sedlis A,Piedmonte MR,et al. A phase Ⅲ randomized trial of postoperative pelvic irradiation in stage ib cervical carcinoma with poor prognostic features:Follow-up of a gynecologic oncology group study[J]. Int J Radiat Oncol Biol Phys,2006,65(1):169-176. DOI:10.1016/j.ijrobp.2005.10.019. [8] Jr SW,Beriwal S,Demanes DJ,et al. American Brachytherapy Society consensus guidelines for adjuvant vaginal cuff brachytherapy after hysterectomy.[J]. Brachytherapy,2015,11(1):58-67. DOI:10.1016/j.brachy.2011.08.005. [9] Mahmoud M,Abdelgeleel S,Mahmoud AM. Impact of postoperative intravaginal brachytherapy on survival for patients with intermediate-risk cervical cancer at National Cancer Institute (NCI),Egypt[J]. J Radiother Pract,2018,17(3):332-336. DOI:10.1017/S1460396918000018. [10] Hao Y,Zhang L,Du X,et al. Postoperative adjuvant chemotherapy combined with intracavitary brachytherapy in early-stage cervical cancer patients with intermediate risk factors[J]. Oncotarg Ther,2016,9:7331-7335. DOI:10.2147/OTT. S107146. [11] Fajaardo RD,Van Os R,Buist MR,et al. Post-operative radiotherapy in patients with early stage cervical cancer[J]. Gynecol Oncol,2014,134(1):52-59. DOI:10.1016/j.ygyno.2014.04.045. [12] Peters WA,Liu PY,Barrett RJ,et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix[J]. J Clin Oncol,2000,18(8):1606-1613. DOI:10.1200/JCO.2000.18.8.1606. [13] Li R,Shinde A,Chen YJ,et al. Survival benefit of adjuvant brachytherapy after hysterectomy with positive surgical margins in cervical cancer.[J]. Int J Radiat Oncol Biol Phys,2018,102(2):373-382. DOI:10.1016/j.ijrobp.2018.05.076. [14] Li L,Kou X,Feng X,et al. Postoperative external beam irradiation with and without brachytherapy in pelvic node-positive IB1-ⅡA2 cervical cancer patients:a retrospective clinical study[J]. Radiat Oncol,2015,10(1):189. DOI:10.1186/s13014-015-0495-4. [15] Grigsby PW,Perez CA. Radiotherapy alone for medically inoperable carcinoma of the cervix:stage ⅠA and carcinoma in situ[J]. Int J Radiat Oncol Biol Phys,1991,21(2):375. DOI:10.1016/0360-3016(91)90785-3. [16] Kim YJ,Lee KJ,Park KR,et al. Prognostic analysis of uterine cervical cancer treated with postoperative radiotherapy:importance of positive or close parametrial resection margin[J]. Radiat Oncol J,2015,33(2):109-116. DOI:10.3857/roj.2015.33.2.109. [17] Kim D,Ki Y,Kim W,et al. Adjuvant external beam radiation and brachytherapy for vaginal resection margin positive cervical cancer[J]. Radiat Oncol J,2018,36(2):147-152. DOI:10.3857/roj.2018.00087. [18] Landoni F,Colombo A,Milani R,et al. Randomized study between radical surgery and radiotherapy for the treatment of stage ⅠB–ⅡA cervical cancer:20-year update[J]. J Gynecol Oncol,2017,28(3). DOI:10.3802/jgo.2017.28.e34. [19] Potter R,Haie-Meder C,Van Limbergen E,et al. Recommendations from gynaecological (GYN) GEC ESTRO working group (Ⅱ):concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy,radiation physics,radiobiotogy[J]. Radiother Oncol,2006,78(1):67-77. DOI:10.1016/j.radonc.2005.11.014. [20] Olszewska AM,Saarnak AE,De Boer RW,et al. Comparison of dose-volume histograms and dose-wall histograms of the rectum of patients treated with intracavitary brachytherapy[J]. Radiother Oncol,2001,61(1):83-85. DOI:10.1016/S0167-8140(01)00400-5. [21] Wachter-Gerstner N,Wachter S,Reinstadler E,et al. Bladder and rectum dose defined from MRI based treatment planning for cervix cancer brachytherapy:Comparison of dose-volume histograms for organ contours and organ wall,comparison with ICRU rectum and bladder reference point[J]. Radiother Oncol,2003,68(3):269-276. DOI:10.1016/S0167-8140(03)00189-0. [22] Lindegaaed JC,Tanderup K,Nielsen SK,et al. MRI-guided 3D optimization significantly improves DVH parameters of pulsed-dose-rate brachytherapy in locally advanced cervical cancer[J]. Int J Radiat Oncol Biol Phys,2008,71(3):756-764. DOI:10.1016/j.ijrobp.2007.10.032. [23] Tanderup K,Nesvacil N,Poetter R,et al. Uncertainties in image guided adaptive cervix cancer brachytherapy:Impact on planning and prescription[J]. Radiother Oncol,2013,107(1):1-5. DOI:10.1016/j.radonc.2013.02.014. [24] Choo JJ,Scudiere J,Bitterman P,et al. Vaginal lymphatic channel location and its implication for intracavitary brachytherapy radiation treatment[J]. Brachytherapy,2005,4(3):236-240. [25] Demanes DJ,Rege S,Rodriquez RR,et al. The use and advantages of a multichannel vaginal cylinder in high-dose-rate brachytherapy[J]. Int J Radiat Oncol Biol Phys,1999,44(1):211-219. DOI:10.1016/S0360-3016(98)00453-2.