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A meta-analysis of comparing hypofractionated radiotherapy versus conventionally fractionated radiotherapy in post-mastectomy breast cancer
Liu Lei,Ren Bixin,Yang Yongqiang,Zou Li,Guo Qi,Zhu Yaqun,Tian Ye
Department of Radiation Oncology,Second Affiliated Hospital of Soochow University;Institute of Radiation Oncology,Soochow University;Suzhou Key Laboratory for Radiation Oncology,Suzhou 215004,China
AbstractObjective To compare the efficacy between hypofractionated radiotherapy versus conventionally fractionated radiotherapy in post-mastectomy breast cancer by a meta-analysis. Methods The controlled clinical trials of comparing hypofractionated radiotherapy versus conventionally fractionated radiotherapy in post-mastectomy breast cancer were searched from PubMed,EMbase,Cochrane Library,Wanfang database,VIP,CNKI,and CBM databases. The obtained data were analyzed using RevMan 5.3 and Stata 14.0 software. The differences between two groups were estimated by calculating the odds ratio (OR) with 95% confidence interval (CI). Results A total of 19 controlled clinical trials involving 2652 post-mastectomy breast cancer patients were selected in this meta-analysis according to the inclusion and exclusion criteria. The meta-analysis results demonstrated that no statistical significance was observed in the tumor-free survival (OR=1.10,95%CI:0.78-1.56,P=0.59), overall survival (OR=1.18,95%CI:0.92-1.53,P=0.19), locoregional recurrence (OR=1.01,95%CI:0.68-1.51,P=0.96), distant metastasis (OR=1.14,95%CI:0.82-1.59,P=0.43), skin toxicity (OR=1.01,95%CI=0.80-2.16,P=0.96), cardiac toxicity (OR=1.17,95%CI:0.71-1.93,P=0.53) and pulmonary toxicity (OR=0.78,95%CI:0.44-1.37,P=0.38) between two groups. Conclusions Hypofractionated radiotherapy and conventionally fractionated radiotherapy post-mastectomy yield similar clinical efficacy, both of which are safe and efficacious radiotherapy patterns. However, the findings remain to be validated by large-scale randomized clinical trials with long-term follow-up of the advanced stage complications.
Liu Lei,Ren Bixin,Yang Yongqiang et al. A meta-analysis of comparing hypofractionated radiotherapy versus conventionally fractionated radiotherapy in post-mastectomy breast cancer[J]. Chinese Journal of Radiation Oncology, 2019, 28(9): 682-686.
Liu Lei,Ren Bixin,Yang Yongqiang et al. A meta-analysis of comparing hypofractionated radiotherapy versus conventionally fractionated radiotherapy in post-mastectomy breast cancer[J]. Chinese Journal of Radiation Oncology, 2019, 28(9): 682-686.
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2019, Vol. 28 
