多种放射性肺损伤动物模型的建立和效应评价研究

doi:10.3760/cma.j.issn.1004-4221.2019.06.017

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Abstract Radiation-induced lung injury (RILI) is a common complication after radiotherapy for thoracic tumors. It is one of the most urgent problems to explore the optimal animal model and evaluate the effect for basic research and drug intervention along with the extensive studies of radiation pneumonia. By reviewing the literatures published in recent 10 years, the selection of irradiation site, determination of irradiation dosage, irradiation method and effect evaluation were statistically compared among different RILI animal models, aiming to explore a stable method of establishing the animal model with RILI and identify a definite effect mechanism. It provides a reliable approach for basic research and drug development to prevent and mitigate the incidence and development of RILI.

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	Articles by authors
	Qi Runzhi
	Liu Jiangang
	Wu Xianwen

Key words： Radiation-induced lung injury Animal model Dose volume relationship Model evaluation

Fund:Fund program:Third Batch of TCM Dominant Disease Project of China Academy of Chinese Medical Sciences (CACMS08y0030)

Corresponding Authors: Wu Xianwen,Email:wxw3705@163.com

Cite this article:

Qi Runzhi,Liu Jiangang,Wu Xianwen. Establishment and effect evaluation of a variety of radiation-induced lung injury animal models[J]. Chinese Journal of Radiation Oncology, 2019, 28(6): 472-475.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2019.06.017 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2019/V28/I6/472

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