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Chinese Journal of Radiation Oncology  2017, Vol. 26 Issue (7): 774-777    DOI: 10.3760/cma.j.issn.1004-4221.2017.07.011
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Dosimetric comparison between three radiotherapy regimens involving supraclavicular and infraclavicular regions in breast cancer patients after breast-conserving surgery
Chen Huiru,Wang shi,Wu Zhaoxia,Li Xiao,Chen Liang,Zhang Jian,Guo Xingdong,Duan Yin,Gan Lin,Yan Cunqing,Zou Yue
Department of Radiation Oncology,The General Hospital of the PLA Rocket Force,Beijing 100088,China (Chen Huiru,Chen Liang,Li Xiao,Zhang Jian,Guo Xingdong,Duan Yin,Yan Cunqing,Zou Yue);Tsinghua University,Beijing 100084,China (Wang Shi,Wu Zhaoxia
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Abstract   Objective To evaluate the dosimetric difference between fixed-field static intensity-modulated radiotherapy (IMRT), fixed-field dynamic multileaf collimator (DMLC), and volumetric modulated arc therapy (VMAT), all of which involve supraclavicular and infraclavicular regions, in breast cancer patients after breast-conserving surgery. Methods This study included 14 female patients with breast cancer who received radiotherapy after breast-conserving surgery in our hospital from October 2012 to April 2016. The radiation field included the chest wall and supraclavicular and infraclavicular regions. IMRT, DMLC, and VMAT plans were generated for each patient while using identical optimization conditions. The doses to planning target volume (PTV) and organs at risk (OARs) were compared based on dose-volume histogram (DVH);one-way analysis of variance or nonparametric Wilcoxon rank test was used for comparison. Results For the dose distribution of PTV, VMAT achieved the best V95, V98, CI, and HI (P<0.009). Concerning the doses to OARs, VMAT achieved the best V5, V20, and Dmean of the ipsilateral lung and the best V5 and Dmean of the contralateral lung (P<0.022). Dmean of the spinal cord was significantly lower in VMAT than in IMRT and DMLC (P=0.004). Conclusions VMAT is preferred for the patients with breast cancer to be treated with radiotherapy involving supraclavicular and infraclavicular regions after breast-conserving surgery. It can improve the dose distribution of target and reduce the doses to organs at risk and radiotherapy toxicities.
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Articles by authors
Chen Huiru
Wang shi
Wu Zhaoxia
Li Xiao
Chen Liang
Zhang Jian
Guo Xingdong
Duan Yin
Gan Lin
Yan Cunqing
Zou Yue
Key words Breast neoplasms/intensity-modulated radiotherapy      Breast neoplasms/volume modulated arc therapy      Dosimetry     
Received: 11 January 2017     
Corresponding Authors: Zou Yue,Email:zyzy4145@163.com   
Cite this article:   
Chen Huiru,Wang shi,Wu Zhaoxia et al. Dosimetric comparison between three radiotherapy regimens involving supraclavicular and infraclavicular regions in breast cancer patients after breast-conserving surgery[J]. Chinese Journal of Radiation Oncology, 2017, 26(7): 774-777.
Chen Huiru,Wang shi,Wu Zhaoxia et al. Dosimetric comparison between three radiotherapy regimens involving supraclavicular and infraclavicular regions in breast cancer patients after breast-conserving surgery[J]. Chinese Journal of Radiation Oncology, 2017, 26(7): 774-777.
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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2017.07.011     OR     http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2017/V26/I7/774
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