电离辐射导致神经发生障碍的分子机制研究现状

doi:10.3760/cma.j.issn.1004-4221.2017.04.025

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Abstract With the development of modern radiotherapy techniques, radiotherapy has been widely used in the multimodality therapy for various malignant tumors, including head and neck cancers such as nasopharyngeal cancer and laryngeal cancer. A combination of surgery and radiochemotherapy significantly improves patients’ cure rate and survival time;however, with the increase in survival time, some patients receiving radiotherapy develop marked cognitive impairment. Ionizing radiation-induced cognitive impairment mainly manifests as hippocampus-dependent cognitive impairment, which is associated with inhibited hippocampal neurogenesis due to ionizing radiation. Therefore, it is necessary to investigate the mechanisms of the inhibition of hippocampal neurogenesis by ionizing radiation. This article reviews the molecular mechanism of neurogenesis disorders induced by ionizing radiation.

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	Articles by authors
	Huang Ping
	Zhang Liyuan
	Yang Hongying
	Tian Ye

Key words： Radiation Neurogenesis Neural stem/progenitor cell Brain microenviorment Inflammation

Received: 22 February 2016

Fund:Project for Priority Discipline Construction of Jiangsu Institutions of Higher Education (Clinical Medicine);Collaborative Innovation Center of Jiangsu Universities (Radiology);Suzhou Key Laboratory, Project of Suzhou Science and Technology Development Plan (SZS201509);Science and Technology Special Project in Clinical Medicine of Jiangsu Province (BL2014040):General Project of National Natural Science Foundation of China (81372411, 81402517, 81472804)

Corresponding Authors: Zhang Liyuan,Email:zhangliyuan126@126.com

Cite this article:

Huang Ping,Zhang Liyuan,Yang Hongying et al. Current research on molecular mechanism of ionizing radiation-induced neurogenesis disorders[J]. Chinese Journal of Radiation Oncology, 2017, 26(4): 481-484.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2017.04.025 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2017/V26/I4/481

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