B超检测腮腺血流在评价鼻咽癌放疗患者口干程度中的应用

doi:10.3760/cma.j.issn.1004-4221.2017.03.003

Abstract
Figure/Table
References()
Related Citation (15)
Read Tracking
Download Tracking

Download: PDF (770 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS) Supporting Info

Abstract Objective To investigate the effectiveness of ultrasound in evaluating the degree of xerostomia in the patients with nasopharyngeal carcinoma (NPC) receiving intensity-modulated radiotherapy (IMRT). Methods A total of 30 NPC patients who were admitted to our hospital from May 2013 to December 2014 were enrolled in this study. The degree of xerostomia in these NPC patients was scored according to the Radiation Therapy Oncology Group scoring criteria. Color Doppler ultrasound was used to measure the peak systolic blood flow velocity of the parotid gland and submandibular gland and the changes in vascular diameter of the parotid gland in the NPC patients before, during, and after IMRT. The correlation between each parameter and the degree of xerostomia was determined by analysis of variance. Results In the 28 NPC patients included in the statistical analysis, the degree of xerostomia during IMRT was significantly higher than that before IMRT (P=0.024), and the degree of xerostomia at 3 months after IMRT was significantly lower than that during IMRT (P=0.035). The peak systolic blood flow velocity of the parotid gland and submandibular gland and the proportion of patients with decreases in vascular diameter of the parotid gland during IMRT were significantly higher than those before IMRT (P=0.001 and 0.003;P=0.001);the above parameters at 3 months after IMRT were significantly lower than those during IMRT (P=0.008 and 0.012;P=0.001). During IMRT and after IMRT, the degree of xerostomia was significantly correlated with the peak systolic blood flow velocity of the parotid gland (r=0.563, P=0.026;r=0.409, P=0.031). Conclusions Ultrasound can be used as a noninvasive detection for the hemodynamic changes in the parotid gland, and it has a certain clinical reference value for evaluating the degree of xerostomia in NPC patients during and after IMRT.

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Luo Zhanxiong
	Zheng Qingping
	Xie Xiangbo
	Li Jing
	Zhou Yuanyuan
	Yu Bin
	Li Zhonghua

Key words： Blood flow of parotid gland Xerostomia B ultrasound detection Nasopharyngeal neoplasms/radiotherapy

Received: 15 August 2016

Cite this article:

Luo Zhanxiong,Zheng Qingping,Xie Xiangbo et al. Application of ultrasound in evaluating degree of xerostomia in patients with nasopharyngeal carcinoma receiving radiotherapy[J]. Chinese Journal of Radiation Oncology, 2017, 26(3): 261-264.

URL:

http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2017.03.003 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2017/V26/I3/261

[1] 杜莉莉,周同冲,石兴源,等.鼻咽癌IMRT51例临床疗效分析[J].国际医药卫生导报,2010,16(24):2992-2996.DOI:10.3760/cma.j.issn.1007-1245.2010.24.015.
Du LL,Zhou TC,Shi XY,et al. Clinical curative analysis on intensify modulated radiotherapy to 51 cases of nasopharyngeal carcinoma[J].Int Med Health Guid News,2010,16(24):2992-2996.DOI:10.3760/cma.j.issn.1007-1245.2010.24.015.
[2] 袁东杰,卢振民,徐志文.鼻咽癌放疗后口干燥症防治的研究进展[J].临床耳鼻咽喉头颈外科杂志,2015,29(7):674-676.
Yuan DJ,Lu ZM,Xu ZW.Studies progress in preventing xerostomia after radiotherapy of nasopharyngeal carcinoma[J].J Clin Otorhinolaryngol Head Neck Surg,2015,29(7):674-676.
[3] 孙久波,郝俊芳,杨新华,等.鼻咽癌常规放疗与IMRT的临床研究[J].中华肿瘤防治杂志,2012,19(19):1495-1498.
Sun JB,Hao JF,Yang XH,et al. Conventional radiotherapy and intensity-modulated radiotherapy for nasopharyngeal carcinoma[J].Chin J Cancer Prev Treat,2012,19(19):1495-1498.
[4] 杨军英,冉炜,林焕彩,等.彩色多普勒超声评价腮腺血流与唾液分泌的关系[J].中山医科大学学报,2002,23(1):76-78.DOI:10.3321/j.issn:1672-3554.2002.01.022.
Yang JY,Ran W,Lin HC,et al. Relationship between the blood flow of parotid gland and salivary secretion:evaluation with color Doppler Sonography[J].Acad J Sun Yat-sen Univ Med Sci,2002,23(1):76-78.DOI:10.3321/j.issn:1672-3554.2002.01.022.
[5] 中国鼻咽癌临床分期工作委员会.2010鼻咽癌IMRT靶区及剂量设计指引专家共识[J].中华放射肿瘤学杂志,2011,20(4):267-269.DOI:10.3760/cma.j.issn.1004-4221.2011.04.001.Working Committee on clinical staging of nasopharyngeal carcinoma in China.2010 consensus on the target area and dose design guidelines for intensity modulated radiotherapy in nasopharyngeal carcinoma[J].Chin J Radiat Oncol,2011,20(4):267-269.DOI:10.3760/cma.j.issn.1004-4221.2011.04.001.
[6] 肖巍魏,卢泰祥,李嘉欣,等.常规放疗的鼻咽癌患者生存质量变化趋势研究[J].中华放射肿瘤学杂志,2010,19(2):87-91.DOI:10.3760/cma.j.issn.1004-4221.2010.02.001.
Xiao WW,Lu TX,Li JX,et al. Tendency of quality of life in patients with nasopharyngeal carcinoma treated with conventional radiotherapy[J].Chin J Rad Oncol,2010,19(2):87-91.DOI:10.3760/cma.j.issn.1004-4221.2010.02.001.
[7] Teshima K,Murakami R,Tomitaka E,et al. Radiation-induced parotid gland changes in oral cancer patients:correlation between parotid volume and saliva production[J].Jpn J Clin Oncol,2010,40(1):42-46.DOI:10.1093/jjco/hyp113.
[8] 赵云艳.放射性唾液腺损伤机理的研究进展[J].临床肿瘤学杂志,2010,15(6):572-574.DOI:10.3969/j.issn.1009-0460.2010.06.024.
Zhao YY.Mechanisms of radiation-induced salivary glands dysfunction[J].Chin Clin Oncol,2010,15(6):572-574.DOI:10.3969/j.issn.1009-0460.2010.06.024.
[9] 孔芳芳,应红梅.鼻咽癌IMRT研究进展[J].实用肿瘤杂志,2013,28(5):553-558.
Kong FF,Ying HM.Research progress of intensity modulated radiation therapy for nasopharyngeal carcinoma[J].J Pract Oncol,2013,28(5):553-558.
[10] 韩淑红,于兰,张佩娟,等.局部晚期鼻咽癌诱导化疗后IMRT同期化疗疗效评价[J].中华放射肿瘤学杂志,2013,22(1):47-51.DOI:10.3760/cma.j.issn.1004-4221.2013.01.015.
Han SH,Yu L,Zhang PJ,et al. Therapeutic effect of concurrent chemotherapy and intensity-modulated radiotherapy following induction chemotherapy in patients with locally advanced nasopharyngeal carcinoma[J].Chin J Radiat Oncol,2013,22(1):47-51.DOI:10.3760/cma.j.issn.1004-4221.2013.01.015.
[11] 范秋虹,刘春风,田野.经颅超声多普勒对鼻咽癌患者放疗后脑血流变化的监测[J].癌症,2003,22(10):1081-1083.DOI:10.3321/j.issn:1000-467X.2003.10.017.
Fan QH,Liu CF,Tian Y.Surveillance of cerebral blood circulation changes by transcranial Doppler ultrasonography in patients with nasopharyngeal carcinoma after radiotherapy[J].Chin J Cancer,2003,22(10):1081-1083.DOI:10.3321/j.issn:1000-467X.2003.10.017.
[12] Chen FH,Chiang CS,Wang CC,et al. Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMP-C1 prostate tumors[J].Clin Cancer Res,2009,15(5):1721-1729.DOI:10.1158/1078-0432.CCR-08-1471.
[13] 徐钟慧,王鸿琳,杜德顺,等.多普勒超声观察干燥综合征腮腺病变的血流动力学特征[J].中国医学影像技术,2010,26(9):1674-1677.
Xu ZH,Wang HL,Du DS,et al. Doppler ultrasonographic evaluation of parotid glands in patients with Sjgren′s syndrome[J].Chin J Med Imag Technol,2010,26(9):1674-1677.
[14] 尹榕,杨金升,石向群,等.血管内支架治疗鼻咽癌放疗后颈部血管狭窄2例并文献复习[J].临床放射学杂志,2010,29(1):90-93.
Yin R,Yang JS,Shi XQ,et al. Endovascular stents treatment cervical artery stenosis of nasopharyngeal carcinoma after radiotherapy in 2 cases and literature review[J].J Clin Radiol,2010,29(1):90-93.
[15] 尹榕,杨金升,石向群,等.鼻咽癌放疗后颈部血管狭窄3例分析并文献复习[J].中国实用神经疾病杂志,2010,13(3):8-10.DOI:10.3969/j.issn.1673-5110.2010.03.003.
Yin R,Yang JS,Shi XQ,et al. Analysis of cervical vascular stenosis of nasopharyngeal carcinoma after radiotherapy in 3 cases and literature review[J].Chin J Pract Nervous Dis,2010,13(3):8-10.DOI:10.3969/j.issn.1673-5110.2010.03.003.