Abstract Radiation-induced lung injury is the most common complication after radiotherapy for chest tumor. It is mainly characterized by early radiation-induced pneumonia and late radiation-induced pulmonary fibrosis. Radiation-induced lung injury is closely related not only to irradiation volume and dose, but also to the expression of many cytokines and signal transduction. This paper reviews the research advances in protection against radiation-induced lung injury by various drugs.
Corresponding Authors:
Wang Gaoren,Email:goldenwang2000@163.com
Cite this article:
Gao Zhen,Wang Gaoren,Ju Yongjian. Research advances in protection against radiation-induced lung injury by drugs[J]. Chinese Journal of Radiation Oncology, 2016, 25(12): 1384-1387.
Gao Zhen,Wang Gaoren,Ju Yongjian. Research advances in protection against radiation-induced lung injury by drugs[J]. Chinese Journal of Radiation Oncology, 2016, 25(12): 1384-1387.
[1] Jenkins P,Welsh A.Computed tomography appearance of early radiation injury to the lung:correlation with clinical and dosimetric factors[J].Int J Radiat Oncol Biol Phys,2011,81(1):97-103.10.1016/j.ijrobp.2010.05.017. [2] Jenkins P,Watts J.An improved model for predicting radiation pneumonitis incorporating clinical and dosimetric variables[J].Int J Radiat Oncol Biol Phys,2011,80(4):1023-1029.10.1016/j.ijrobp.2010.03.058. [3] Takigawa N,Kiura K,Segawa Y,et al. Benefits and adverse events among elderly patients receiving concurrent chemoradiotherapy for locally advanced non-small cell lung cancer:analysis of the Okayama lung cancer study group trial 0007[J].J Thorac Oncol,2011,6(6):1087-1091.10.1097/JTO.0b013e318213f86a. [4] Mihandoost E,Shirazi A,Mahdavi S R,et al. Can melatonin help us in radiation oncology treatments?[J].Biomed Res Int,2014,2014:578137.10.1155/2014/578137. [5] Rutkowska ES,Syndikus I,Baker CR,et al. Mechanistic modelling of radiotherapy-induced lung toxicity[J].Br J Radiol,2012,85(1020):e1242-e1248.10.1259/bjr/28365782. [6] Takeda A,Kunieda E,Ohashi T,et al. Severe COPD is correlated with mild radiation pneumonitis following stereotactic body radiotherapy[J].Chest,2012,141(4):858-866.10.1378/chest.11-1193. [7] Vogelius IS,Westerly DC,Cannon GM,et al. Intensity-modulated radiotherapy might increase pneumonitis risk relative to three-dimensional conformal radiotherapy in patients receiving combined chemotherapy and radiotherapy:a modeling study of dose dumping[J].Int J Radiat Oncol Biol Phys,2011,80(3):893-899.10.1016/j.ijrobp.2010.12.073. [8] Vogelius IR,Westerly DC,Aznar MC,et al. Estimated radiation pneumonitis risk after photon versus proton therapy alone or combined with chemotherapy for lung cancer[J].Acta Oncol,2011,50(6):772-776.10.3109/0284186X.2011.582519. [9] Mathew B,Jacobson JR,Berdyshev E,et al. Role of sphingolipids in murine radiation-induced lung injury:protection by sphingosine 1-phosphate analogs[J].FASEB J,2011,25(10):3388-3400.10.1096/fj.11-183970. [10] Gauter-Fleckenstein B,Fleckenstein K,Owzar K,et al. Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage[J].Free Radic Biol Med,2010,48(8):1034-1043.10.1016/j.freeradbiomed.2010.01.020. [11] Kaya V,Yazkan R,YildirimM,et al. The relation of radiation-induced pulmonary fibrosis with stress and the efficiency of antioxidant treatment:an experimental study[J].Med Sci Monit,2014,20:290-296.10.12659/MSM.890334. [12] Lee JC,Kinniry PA,Arguiri E,et al. Dietary curcumin increases antioxidant defenses in lung,ameliorates radiation-induced pulmonary fibrosis,and improves survival in mice[J].Radiat Res,2010,173(5):590-601.10.1667/RR1522.1. [13] Robb WB,Condron C,Moriarty M,et al. Taurine attenuates radiation-induced lung fibrosis in C57/Bl6 fibrosis prone mice[J].Ir J Med Sci,2010,179(1):99-105.10.1007/s11845-009-0389-2. [14] Koc M,Buyukokuroglu E,Tays S.Theeffectofmela-tonin on peripheral blood cells during total body irradiation in rats[J].Biol Phar Bull,2002,25(5):656-657. [15] Sharma S,Haldar C,Chaube SK,et al. Long-term melatonin administration attenuates low-LET γ-radiation-induced lymphatic tissue injury during the reproductively active and inactive phases of Indian palm squirrels (Funambulus pennanti)[J].Br J Radiol,2010,83(986):137-151.10.1259/bjr/73791461. [16] Medhora M,Gao F,Jacobs ER,et al. Radiation damage to the lung:mitigation by angiotensin-converting enzyme (ACE) inhibitors[J].Respirology,2012,17(1):66-71.10.1111/j.1440-1843.2011.02092.x. [17] Ghosh SN,Zhang R,Fish BL,et al. Renin-angiotensin system suppression mitigates experimental radiation pneumonitis[J].Int J Radiat Oncol Biol Phys,2009,75(5):1528-1536. [18] Anscher MS,Thrasher B,Zgonjanin L,et al. Small molecular inhibitor of transforming growth factorbeta protects against development of radiationinduced lung injury[J]. Int J Radiat Oncol Biol Phys,2008,71(3):829-837. [19] Garofalo MC,Ward AA,Farese AM,et al. A pilot study in rhesus macaques to assess the treatment efficacy of a small molecular weight catalytic metalloporphyrin antioxidant (AEOL 10150) in mitigating radiation-induced lung damage[J].Health Phys,2014,106(1):73-83.10.1097/HP.0b013e3182a4 d967. [20] Ogata T,Yamazaki H,Teshima T,et al. Early administration of IL-6RA does not prevent radiation-induced lung injury in mice[J].Radiat Oncol,2010,5:26.10.1186/1748-717X-5-26. [21] Fox J,Gordon JR,Haston CK.Combined CXCR1/CXCR2 antagonism decreases radiation-induced alveolitis in the mouse[J].Radiat Res,2011,175(5):657-664.10.1667/RR2449.1. [22] Rabbani ZN,Mi J,Zhang Y,et al. Hypoxia inducible factor 1α signaling in fractionated radiation-induced lung injury:role of oxidative stress and tissue hypoxia[J].Radiat Res,2010,173(2):165-174.10.1667/RR1816.1. [23] Huang YJ,Liu W,Liu H,et al. Grape seed pro-anthocyanidins ameliorates radiation-induced lung injury[J].J Cell Mol Med,2014,18(7):1267-1277.10.1111/jcmm.12276. [24] Thomas DM,Fox J,Haston CK.Imatinib therapy reduces radiation-induced pulmonary mast cell influx and delays lung disease in the mouse[J].Int J Radiat Biol,2010,86(6):436-444.10.3109/09553001003674863. [25] Puthawala K,Hadjiangelis N,Jacoby SC,et al. Inhibition of integrin alpha (v) beta6, an activator of latent transforming growth factor-beta, prevents radiationinduced lung fibrosis[J].Am J Respir Crit Care Med,2008,177(1):82-90. [26] Monceau V, Pasinetti N, Schupp C, et al. Modulation of the Rho/ROCK pathway in heart and lung after thorax irradiation reveals targets to improve normal tissue toxicity[J]. Curr Drug Targets,2010,11(11):1395-1404. [27] 房丽,荣绍元,王红阳,等.地塞米松防治急性放射性肺损伤疗效观察[J].山东医药,2009,49(4):49-50. Fang L,Rong ZHY,Wang HY,et al. Observation of the effect of dexamethasone on acute lung injury induced by radiation[J].Shandong Med J,2009,49(4):49-50. [28] 蔡红兵,罗荣城.放射性肺损伤的中医药防治方法探讨[J].南方医科大学学,2003,23(9):958-960. Cai HB, Luo RC.Prevention and therapy of radiation induced pulmonary injury with traditional Chinese medicine[J].J Southern Med Uni,2003,23(9):958-960. [29] Xiao C,Ding HJ,Feng LC,et al. Efficacy of Liang xue Jie du Huo xue Decoction in prevention of radiation pneumonitis:a randomized controlled trial[J].Chin J Integrat Med,2010,8(7):624-628. [30] 戴夕超,杜秀平,张西志,等.双氢青蒿素对早期放射性肺损伤大鼠TNF-α表达的影响[J].中华肿瘤防治杂志,2010,17(10):728-731. Dai XCH,Du XP,Zhang XZH,et al. Effect of artemisinin on the expression of TNF-in rats with early radiation-induced lung injury[J].Chin J Cancer Prev Treat,2010,17(10):728-731. [31] 俞静,花宝金,朴炳奎.延胡索乙素对放射所致血管内皮细胞损伤的保护作用[J].中华肿瘤防治杂志,2011,18(8):584-587. Yu J,Hua BJ,Pu BK.The protective effect of tetrahydropalmatine on vascular endothelial cell injury induced by radiation[J].Chin J Cancer Prev Treat,2011,18(8):584-587. [32] 王晓萍,张道富,张新良,等.汉防己甲素防治放射性肺损伤的临床观察[J].中华肿瘤防治杂志,2010,17(18):1457-1459. Wang XP,Zhang DF,Zhang XL,et al. Tetrandrine clinical observation on prevention and treatment of radiation-induced lung injury[J].Chin J Cancer Prev Treat,2010,17(18):1457-1459. [33] 李鑫,薛建新,卢铀.白藜芦醇对急性放射性肺损伤保护效应的实验研究[J].肿瘤,2011,31(5):395-399. Li X,Xue JX,Lu Y.Experimental study on protective effect of resveratrol on acute lung injury induced by radiation[J].Oncology,2011,31(5):395-399.
2016, Vol. 25 
