3DCT和4DCT扫描下不同运动频率对运动中大体肿瘤体积的影响

doi:10.3760/cma.j.issn.1004-4221.2016.09.021

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Abstract Objective To investigate the impact of movement frequency on gross tumor volume (GTV) of moving tumors and coordinate position of the central point based on three-and four-dimensional CT scans. Methods The respiratory motion platform from Modus and 8 phantoms with different shapes and volumes were used to simulate the movement of lung tumors. Three-and four-dimensional CT scans were performed at movement frequencies of 10, 15, and 20 times/min. GTV (GTV₁₀, GTV₁₅, and GTV₂₀) and IGTV (IGTV₁₀, IGTV₁₅, and IGTV₂₀) were delineated, and the coordinate position of the central point was obtained. The Friedman test was performed for GTV₁₀, GTV₁₅, GTV₂₀, IGTV₁₀, IGTV₁₅, IGTV₂₀, and the coordinate position of the central point. Results GTV₁₀, GTV₁₅, and GTV₂₀ at the three movement frequencies were 12.41±14.26 cm³, 10.38±11.18 cm³, and 12.50±15.23 cm³, respectively (P=0.687), and the positional values were -8.2±96.2 mm, -8.6±96.1 mm, and -8.6±95.7 mm in x-axis (P=0.968), 108.2±25.0 mm, 110.4±22.5 mm, and 109.0±24.2 mm in y-axis (P=0.028), and 65.2±13.7 mm, 65.4±13.4 mm, and 65.4±13.2 mm in z-axis (P=0.902). IGTV₁₀, IGTV₁₅, and IGTV₂₀ at the three movement frequencies were 17.78±19.42 cm³, 17.43±19.56 cm³, and 17.44±18.80 cm³, respectively (P=0.417), and the positional values were -7.7±95.9 mm, -7.9±95.6 mm,and -7.9±95.1 mm in x-axis (P=0.325), 109.4±24.5 mm, 109.6±24.1 mm, and 109.2±24.3 mm in y-axis (P=0.525), and 65.5±13.3 mm, 65.6±13.4 mm, and 65.5±13.3 mm in z-axis (P=0.093). Conclusions During simulated positioning of thoracic tumors, respiratory movement frequency has no significant impact on target volume established by four-dimensional CT scan. There are no significant differences in three-dimensional target volume established at different respiratory frequencies, but respiratory frequency has a significant impact on the position of the central point of the target volume in y-axis.

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	Articles by authors
	Shang Dongping
	Xing Jianhong
	Zhang Qiang
	Yin Yong

Key words： Respiratory movement Target volume Tomography X-ray computed Body phantom

Received: 17 September 2015

Cite this article:

Shang Dongping,Xing Jianhong,Zhang Qiang et al. Impact of movement frequency on gross tumor volume of moving tumors based on three-and four-dimensional CT scans[J]. Chinese Journal of Radiation Oncology, 2016, 25(9): 994-998.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2016.09.021 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2016/V25/I9/994

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