AbstractObjective This study retrospectively analyzed the efficacy and toxicity profile of hyperfractionated intensity-modulated radiotherapy (HF-IMRT) for locally recurrent nasopharyngeal carcinoma (NPC). Methods Twenty-eight locally recurrent patients of NPC were enrolled,23 male and 5 female with a median of 51 years (range 25-74 years).All patients had a median recurrent time of 17.5 months and received HF-IMRT with a total dosage of 60-70 Gy,each consisting of 1.2 Gy per fraction,each of the 2 fractions were spaced 6 hours apart and lasting for 5 days. Twenty-five patients received concurrent chemotherapy of nedaplatin or two agent regimen,4 patients received Ad-p53 gene therapy and 6 patients received target therapy of EGFR monoclony antibody. Results The complete response and partial response rates were 89%(25/28) and 11%(3/28) after being treated by HF-IMRT for 3 months. The median follow-up time was 27.5 months. The 1,2,3-year overall survival rates,locoregional recurrence-free survival rates and progression-free survival rates were 100%,91%,80%;100%,80%,55%;88%,65%,55%,respectively. Three patient were observed to develop severe nasopharyngeal necrosis but recover after treatment,no patients experienced hemorrhage of nasopharynx. Multivariate analysis indicated that the poor prognostic factors included tumor stages (T3-T4)(P=0.00) and no chemotherapy (P=0.04). Conclusion HF-IMRT is feasible for locally recurrent nasopharyngeal carcinoma with satisfactory local control and controllable adverse reaction,it is worth further clinical studies.
Corresponding Authors:
He Xia,Email:hexia200302@tom.com
Cite this article:
Yin Li,Guo Wenjie,Xie Peng et al. Efficacy of intensity-modulated radiotherapy on patients with locally recurrent nasopharyngeal carcinoma[J]. Chinese Journal of Radiation Oncology, 2016, 25(9): 917-922.
Yin Li,Guo Wenjie,Xie Peng et al. Efficacy of intensity-modulated radiotherapy on patients with locally recurrent nasopharyngeal carcinoma[J]. Chinese Journal of Radiation Oncology, 2016, 25(9): 917-922.
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