左乳腺癌保乳术后CRT和FIF-IMRT及逆向IMRT剂量学比较

doi:10.3760/cma.j.issn.1004-4221.2016.07.017

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Abstract Objective To investigate the differences in dosimetry between conformal radiotherapy (CRT), field-in-field intensity-modulated radiotherapy (FIF-IMRT), and intensity-modulated radiotherapy (IMRT) after breast-conserving surgery for left-sided breast cancer. Methods A total of 31 patients who underwent breast-conserving surgery for left-sided breast cancer were randomly selected, and the plans for CRT, FIF-IMRT, and IMRT were developed. The dose-volume histogram (DVH) was used for self-control study, and the non-parametric test was used to compare the differences in target volume and doses to organs at risk (OARs). Results All the three methods met the requirements of the prescribed doses. The CRT group had a higher V₁₀₅ of the target volume and higher heart V₃₀ and D_max(P=0.000,0.000,0.000). The IMRT group had higher V₅ and D_mean(P=0.000,0.000), as well as a higher lung V₅ and a lower lung V₄₀(P=0.000,0.000). The FIF-IMRT group had the lowest D_mean(P=0.000), and the IMRT group had significantly higher D_mean and D_max of the right lung and the spinal cord than the other two groups (P=0.000,0.000,0.000,0.000). The FIF-IMRT group had a significantly lower single hop count than the other two groups (P=0.000). Conclusions CRT has a good dose distribution in the target volume, but greatly injures the surrounding tissues. FIF-IMRT can well protect OARs and cause less damage to the device.

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	Articles by authors
	Huo Wen
	Ning Bo
	Hu Jing
	Xu Mei
	Liu Gang

Key words： Breast neoplasms/radiotherapy Radiotherapy,conventional Radiotherapy,inverse intensity-modulated Radiotherapy,field in field intensity-modulated Dosimetr

Received: 08 January 2015

Cite this article:

Huo Wen,Ning Bo,Hu Jing et al. Dosimetry of conformal radiotherapy, field-in-field intensity-modulated radiotherapy, and inverse-planned intensity-modulated radiotherapy after breast-conserving surgery for left-sided breast cancer:a comparative analysis[J]. Chinese Journal of Radiation Oncology, 2016, 25(7): 745-747.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2016.07.017 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2016/V25/I7/745

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