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Practice of proton and heavy ion radiotherapies for head and neck malignancies
Kong Lin,Lu Jiande
Department of Radiation Oncology (Kong L, Lu JD),Shanghai Proton and Heavy Ion Center,Shanghai 201315,China;Department of Radiation Oncology (Kong L),Cnacer Hospital,Fudan University,Shanghai 200032,China
Abstract Radiotherapy is an important therapeutic method in the management of head and neck cancer. However, since the head and neck region has many important functions of the human body, radiotherapy may cause serious sequelae. Proton and heavy ion radiotherapies have better radiophysical and biological properties compared with conventional proton beam and are beneficial to tumor control and protection of normal tissue. The advantages of proton and heavy ion radiotherapies have been demonstrated in soft tissue tumors (especially skull base chordoma and chondrosarcoma), malignant melanoma, and adenoid cystic carcinoma resistant to conventional protons in the head and neck region, and the safety of proton and heavy ion radiotherapies have been confirmed in reirradiation for recurrent tumors.
Kong Lin,Lu Jiande. Practice of proton and heavy ion radiotherapies for head and neck malignancies[J]. Chinese Journal of Radiation Oncology, 2016, 25(5): 427-431.
Kong Lin,Lu Jiande. Practice of proton and heavy ion radiotherapies for head and neck malignancies[J]. Chinese Journal of Radiation Oncology, 2016, 25(5): 427-431.
[1]Jakobi A,Bandurska-Luque A,Stützer K,et al. Identification of patient benefit from proton therapy for advanced head and neck cancer patients based on individual and subgroup normal tissue complication probability analysis[J].Int J Radiat Oncol Biol Phys,2015,92(5):1165-1174.DOI:10.1016/j.ijrobp.2015.04.031. [2]van der Laan HP,van de Water TA,van Herpt HE,et al. The potential of intensity-modulated proton radiotherapy to reduce swallowing dysfunction in the treatment of head and neck cancer:a planning comparative study[J].Acta Oncol,2013,52(3):561-569.DOI:10.3109/0284186X.2012.692885. [3]van de Water TA,Lomax AJ,Bijl HP,et al. Potential benefits of scanned intensity-modulated proton therapy versus advanced photon therapy with regard to sparing of the salivary glands in oropharyngeal cancer[J].Int J Radiat Oncol Biol Phys,2011,79(4):1216-1224.DOI:10.1016/j.ijrobp.2010.05.012. [4]Lewis GD,Holliday EB,Kocak-Uzel E,et al. Intensity-modulated proton therapy for nasopharyngeal carcinoma:decreased radiation dose to normal structures and encouraging clinical outcomes[J].Head Neck,2015.DOI:10.1002/hed.24341. [5]Mock U,Georg D,Bogner J,et al. Treatment planning comparison of conventional,3D conformal,and intensity-modulated photon (IMRT) and proton therapy for paranasal sinus carcinoma[J].Int J Radiat Oncol Biol Phys,2004,58(1):147-154.DOI:10.1016/S0360-3016(03)01452-4. [6]Torres MA,Chang EL,Mahajan A,et al. Optimal treatment planning for skull base chordoma:photons,protons,or a combination of both[J].Int J Radiat Oncol Biol Phys,2009,74(4):1033-1039.DOI:10.1016/j.ijrobp.2008.09.029. [7]Feuvret L,Noel G,Weber DC,et al. A treatment planning comparison of combined photon-proton beams versus proton beams-only for the treatment of skull base tumors[J].Int J Radiat Oncol Biol Phys,2007,69(3):944-954.DOI:10.1016/j.ijrobp.2007.07.2326. [8]Huang YW,Hsiao YY,Chao TC,et al. Monte Carlo simulations of the relative biological effectiveness for DNA double strand breaks from 300 MeV u-1 carbon-ion beams[J].Phys Med Biol,2015,60(15):5995-6012.DOI:10.1088/0031-9155/60/15/5995. [9]Munzenrider JE,Liebsch NJ.Proton therapy for tumors of the skull base[J].Strahlenther Onkol,1999,175(2S):57-63.DOI:10.1007%2FBF03038890. [10]Resto VA,Chan AW,Deschler DG,et al. Extent of surgery in the management of locally advanced sinonasal malignancies[J].Head Neck,2008,30(2):222-229.DOI:10.1002/hed.20681. [11]Mizoe JE,Hasegawa A,Jingu K,et al. Results of carbon ion radiotherapy for head and neck cancer[J].Radiother Oncol,2012,103(1):32-37.DOI:10.1016/j.radonc.2011.12.013. [12]Catton C,O′Sullivan B,Bell R,et al. Chordoma:long-term follow-up after radical photon irradiation[J].Radiother Oncol,1996,41(1):67-72.DOI:10.1016/S0167-8140(96)91805-8. [13]Romero J,Cardenes H,la Torre A,et al. Chordoma:results of radiation therapy in eighteen patients[J].Radiother Oncol,1993,29(1):27-32.DOI:10.1016/0167-8140(93)90169-9. [14]Forsyth PA,Cascino TL,Shaw EG,et al. Intracranial chordomas:a clinicopathological and prognostic study of 51 cases[J].J Neurosurg,1993,78(5):741-747.DOI:10.3171/jns.1993.78.5.0741. [15]Magrini SM,Papi M,Marletta F,et al. Chordoma-natural history,treatment and prognosis. The Florence Radiotherapy Department experience (1956-1990) and a critical review of the literature[J].Acta Oncol,1992,31(8):847-851.DOI:10.3109/02841869209089717. [16]Hug EB,Loredo LN,Slater JD,et al. Proton radiation therapy for chordomas and chondrosarcomas of the skull base[J].J Neurosurg,1999,91(3):432-439.DOI:10.3171/jns.1999.91.3.0432. [17]NoBIG,Habrand JL,Jauffret E,et al. Radiation therapy for chordoma and chondrosarcoma of the skull base and the cervical spine. Prognostic factors and patterns of failure[J].Strahlenther Onkol,2003,179(4):241-248.DOI:10.1007/s00066-003-1065-5. [18]Ares C,Hug EB,Lomax AJ,et al. Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base:first long-term report[J].Int J Radiat Oncol Biol Phys,2009,75(4):1111-1118.DOI:10.1016/j.ijrobp.2008.12.055. [19]Weber DC,Badiyan S,Malyapa R,et al. Long-term outcomes and prognostic factors of skull-base chondrosarcoma patients treated with pencil-beam scanning proton therapy at the Paul Scherrer Institute[J].Neuro Oncol,2016,18(2):236-243.DOI:10.1093/neuonc/nov154. [20]Mizoe JE,Hasegawa A,Takagi R,et al. Carbon ion radiotherapy for skull base chordoma[J].Skull Base,2009,19(3):219-224.DOI:10.1055/s-0028-1114295. [21]Uhl M,Mattke M,Welzel T,et al. Highly effective treatment of skull base chordoma with carbon ion irradiation using a raster scan technique in 155 patients:first long-term results[J].Cancer,2014,120(21):3410-3417.DOI:10.1002/cncr.28877. [22]Uhl M,Mattke M,Welzel T,et al. High control rate in patients with chondrosarcoma of the skull base after carbon ion therapy:first report of long-term results[J].Cancer,2014,120(10):1579-1585.DOI:10.1002/cncr.28606. [23]Nikoghosyan AV,Karapanagiotou-Schenkel I,Münter MW,et al. Randomised trial of proton vs.carbon ion radiation therapy in patients with chordoma of the skull base,clinical phase Ⅲ study HIT-1-Study[J].BMC Cancer,2010,10:607.DOI:10.1186/1471-2407-10-607. [24]Nikoghosyan AV,Rauch G,Münter MW,et al. Randomised trial of proton vs.carbon ion radiation therapy in patients with low and intermediate grade chondrosarcoma of the skull base,clinical phase Ⅲ study[J].BMC Cancer,2010,10(1):606.DOI:10.1186/1471-2407-10-606. [25]Jingu K,Tsujii H,Mizoe JE,et al. Carbon ion radiation therapy improves the prognosis of unresectable adult bone and soft-tissue sarcoma of the head and neck[J].Int J Radiat Oncol Biol Phys,2012,82(5):2125-2131.DOI:10.1016/j.ijrobp.2010.08.043. [26]Trotti A,Peters LJ.Role of radiotherapy in the primary management of mucosal melanoma of the head and neck[J].Semin Surg Oncol,1993,9(3):246-250. [27]Moreno MA,Roberts DB,Kupferman ME,et al. Mucosal melanoma of the nose and paranasal sinuses,a contemporary experience from the M.D.Anderson Cancer Center[J].Cancer,2010,116(9):2215-2223.DOI:10.1002/cncr.24976. [28]Zenda S,Kawashima M,Nishio T,et al. Proton beam therapy as a nonsurgical approach to mucosal melanoma of the head and neck:a pilot study[J].Int J Radiat Oncol Biol Phys,2010,81(1):135-139.DOI:10.1016/j.ijrobp.2010.04.071. [29]Zenda S,Nishio T,Mizumoto M,et al. Phase Ⅱ study of proton beam therapy as a nonsurgical approach for mucosal melanoma of the nasal cavity or para-nasal sinuses[J].Radiother Oncol,2016,118(2):267-271.DOI:10.1016/j.radonc.2015.10.025. [30]Demizu Y,Terashima OFK,Mima M,et al. Particle therapy for mucosal melanoma of the head and neck. A single-institution retrospective comparison of proton and carbon ion therapy[J].Strahlenther Onkol,2014,190(2):186-191.DOI:10.1007/s00066-013-0489-9. [31]Yanagi T,Mizoe JE,Hasegawa A,et al. Mucosal malignant melanoma of the head and neck treated by carbon ion radiotherapy[J].Int J Radiat Oncol Biol Phys,2009,74(1):15-20.DOI:10.1016/j.ijrobp.2008.07.056. [32]Tsujii H,Kamada T,Shirai T,et al. Carbon-ion radiotherapy[M].Japan:Springer,2014.DOI:10.1007/978-4-431-54457-9. [33]Balamucki CJ,Amdur RJ,Werning JW,et al. Adenoid cystic carcinoma of the head and neck[J].Am J Otolaryngol,2012,33(5):510-518.DOI:10.1016/j.amjoto.2011.11.006. [34]Shen CY,Xu TT,Huang CP,et al. Treatment outcomes and prognostic features in adenoid cystic carcinoma originated from the head and neck[J].Oral Oncol,2012,48(5):445-449.DOI:10.1016/j.oraloncology.2011.12.002. [35]Mizoe JE,Tsujii H,Kamada T,et al. Dose escalation study of carbon ion radiotherapy for locally advanced head-and-neck cancer[J].Int J Radiat Oncol Biol Phys,2004,60(2):358-364.DOI:10.1016/j.ijrobp.2004.02.067. [36]Koto M,Hasegawa A,Takagi R,et al. Evaluation of the safety and efficacy of carbon ion radiotherapy for locally advanced adenoid cystic carcinoma of the tongue base[J].Head Neck,2016.DOI:10.1002/hed.24397. [37]Takagi M,Demizu Y,Hashimoto N,et al. Treatment outcomes of particle radiotherapy using protons or carbon ions as a single-modality therapy for adenoid cystic carcinoma of the head and neck[J].Radiother Oncol,2014,113(3):364-370.DOI:10.1016/j.radonc.2014.11.031. [38]Jensen AD,Nikoghosyan AV,Lossner K,et al. COSMIC:a regimen of intensity modulated radiation therapy plus dose-escalated,raster-scanned carbon ion boost for malignant salivary gland tumors:results of the prospective phase 2 trial[J].Int J Radiat Oncol Biol Phys,2015,93(1):37-46.DOI:10.1016/j.ijrobp.2015.05.013. [39]Jensen AD,Nikoghosyan AV,Poulakis M,et al. Combined intensity-modulated radiotherapy plus raster-scanned carbon ion boost for advanced adenoid cystic carcinoma of the head and neck results in superior locoregional control and overall survival[J].Cancer,2015,121(17):3001-3009.DOI:10.1002/cncr.29443. [40]Jensen AD,Poulakis M,Nikoghosyan AV,et al. Re-irradiation of adenoid cystic carcinoma:analysis and evaluation of outcome in 52 consecutive patients treated with raster-scanned carbon ion therapy[J].Radiother Oncol,2015,114(2):182-188.DOI:10.1016/j.radonc.2015.01.002. [41]Lin R,Slater JD,Yonemoto LT,et al. Nasopharyngeal carcinoma:repeat treatment with conformal proton therapy-dose-volume histogram analysis[J].Radiology,1999,213(2):489-494.DOI:10.1148/radiology.213.2.r99nv29489.